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Growth differentiation factor-15 as a potent predictor of long-term mortality among subjects with osteoarthritis

Background: Subjects with osteoarthritis (OA) are at increased risk for cardiovascular (CV) and all-cause mortality. Whether biomarkers improve outcome prediction in these patients remains to be elucidated. We investigated the association between growth differentiation factor 15 (GDF-15), a novel st...

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Hauptverfasser: Arnold, Natalie (VerfasserIn) , Rehm, Martin (VerfasserIn) , Büchele, Gisela (VerfasserIn) , Peter, Raphael Simon (VerfasserIn) , Brenner, Rolf Erwin (VerfasserIn) , Günther, Klaus-Peter (VerfasserIn) , Brenner, Hermann (VerfasserIn) , Koenig, Wolfgang (VerfasserIn) , Rothenbacher, Dietrich (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 26 September 2020
In: Journal of Clinical Medicine
Year: 2020, Jahrgang: 9, Heft: 10, Pages: 1-14
ISSN:2077-0383
DOI:10.3390/jcm9103107
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/jcm9103107
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2077-0383/9/10/3107
Volltext
Verfasserangaben:Natalie Arnold, Martin Rehm, Gisela Büchele, Raphael Simon Peter, Rolf Erwin Brenner, Klaus-Peter Günther, Hermann Brenner, Wolfgang Koenig, and Dietrich Rothenbacher
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Zusammenfassung:Background: Subjects with osteoarthritis (OA) are at increased risk for cardiovascular (CV) and all-cause mortality. Whether biomarkers improve outcome prediction in these patients remains to be elucidated. We investigated the association between growth differentiation factor 15 (GDF-15), a novel stress-responsive cytokine, and long-term all-cause mortality among OA patients. Methods: Within the Ulm Osteoarthritis Study, GDF-15 has been measured in the serum of 636 subjects, who underwent hip or knee arthroplasty between 1995 and 1996 (median age 65 years). Results: During a median follow-up of 19.7 years, a total of 402 deaths occurred. GDF-15 was inversely associated with walking distance. Compared to the bottom quartile (Q), subjects within the top quartile of GDF-15 demonstrated a 2.69-fold increased risk of dying (hazard ratio (HR) (95% confidence interval (CI)) 2.69 (1.82&ndash;3.96) adjusted for age, sex, BMI, smoking status, localization of OA, diabetes, maximum walking distance, total cholesterol, and cystatin C. Further adjustment for NT-proBNP, troponin I, and hs-C-reactive protein did not change the results appreciably (HR (95%CI) 1.56 (1.07&ndash;2.28); 1.75 (1.21&ndash;2.55); 2.32 (1.55&ndash;3.47) for Q2, Q3, and Q4 respectively, p for trend < 0.001). Conclusions: In subjects with OA, GDF-15 represents a potent predictor of decreased survival over >20 years, independently of conventional CV risk factors, renal, cardiac, and inflammatory biomarkers as well as walking disability, previously associated with increased mortality and lower extremity OA.
Beschreibung:Gesehen am 29.04.2021
Beschreibung:Online Resource
ISSN:2077-0383
DOI:10.3390/jcm9103107

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