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Identification of a myotropic AAV by massively parallel in vivo evaluation of barcoded capsid variants

Adeno-associated virus (AAV) forms the basis for several commercial gene therapy products and for countless gene transfer vectors derived from natural or synthetic viral isolates that are under intense preclinical evaluation. Here, we report a versatile pipeline that enables the direct side-by-side...

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Main Authors: Weinmann, Jonas (Author) , Weis, Sabrina (Author) , Sippel, Josefine (Author) , Tulalamba, Warut (Author) , Remes, Anca (Author) , El Andari, Jihad (Author) , Herrmann, Anne-Kathrin (Author) , Pham, Quang H. (Author) , Borowski, Christopher (Author) , Hille, Susanne (Author) , Schönberger, Tanja (Author) , Frey, Norbert (Author) , Lenter, Martin (Author) , VandenDriessche, Thierry (Author) , Müller, Oliver J. (Author) , Chuah, Marinee K. (Author) , Lamla, Thorsten (Author) , Grimm, Dirk (Author)
Format: Article (Journal)
Language:English
Published: 28 October 2020
In: Nature Communications
Year: 2020, Volume: 11, Pages: 1-12
ISSN:2041-1723
DOI:10.1038/s41467-020-19230-w
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41467-020-19230-w
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-020-19230-w
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Author Notes:Jonas Weinmann, Sabrina Weis, Josefine Sippel, Warut Tulalamba, Anca Remes, Jihad El Andari, Anne-Kathrin Herrmann, Quang H. Pham, Christopher Borowski, Susanne Hille, Tanja Schönberger, Norbert Frey, Martin Lenter, Thierry VandenDriessche, Oliver J. Müller, Marinee K. Chuah, Thorsten Lamla & Dirk Grimm

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