Glycogen synthase kinase 3β (GSK3β) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone
On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3β (GSK3β) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/β-catenin signaling pathway appear to...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 18, 2007
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| In: |
Journal of proteome research
Year: 2007, Volume: 6, Issue: 3, Pages: 1198-1208 |
| ISSN: | 1535-3907 |
| DOI: | 10.1021/pr0605825 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/pr0605825
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| Author Notes: | Martin H. Maurer, Jens O. Brömme, Robert E. Feldmann, Anne Järve, Fatemeh Sabouri, Heinrich F. Bürgers, Dominik W. Schelshorn, Carola Krüger, Armin Schneider, and Wolfgang Kuschinsky |
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| 520 | |a On the basis of its inhibition by SB216763, we identified the multifunctional enzyme Glycogen Synthase Kinase 3β (GSK3β) as a central regulator for differentiation and cell survival of adult neural stem cells. Detected by proteomic approaches, members of the Wnt/β-catenin signaling pathway appear to participate in enhanced neuronal differentiation and activated transcription of β-catenin target genes during GSK3β inhibition, associated with decreased apoptosis. Keywords: Neural stem cell • Neurosphere • Glycogen Synthase Kinase 3β • Two-dimensional gel electrophoresis • Rat • Subventricular zone | ||
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