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Odontoblast TRPC5 channels signal cold pain in teeth

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Teeth are composed of many tissues, covered by an inflexible and obdurate enamel. Unlike most other tissues, teeth become extremely cold sensitive when inflamed. The mechanisms of this cold sensation are not understood. Here, we clarify the molecular and cellular components of the dental cold sensin...

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Main Authors: Bernal, Laura (Author) , Sotelo-Hitschfeld, Pamela (Author) , König, Christine (Author) , Sinica, Viktor (Author) , Wyatt, Amanda (Author) , Winter, Zoltan (Author) , Hein, Alexander (Author) , Touska, Filip (Author) , Reinhardt, Susanne (Author) , Tragl, Aaron (Author) , Kusuda, Ricardo (Author) , Wartenberg, Philipp (Author) , Sclaroff, Allen (Author) , Pfeifer, John D. (Author) , Ectors, Fabien (Author) , Dahl, Andreas (Author) , Freichel, Marc (Author) , Vlachova, Viktorie (Author) , Brauchi, Sebastian (Author) , Roza, Carolina (Author) , Boehm, Ulrich (Author) , Clapham, David E. (Author) , Lennerz, Jochen K. (Author) , Zimmermann, Katharina (Author)
Format: Article (Journal)
Language:English
Published: 26 March 2021
In: Science advances
Year: 2021, Volume: 7, Issue: 13
ISSN:2375-2548
DOI:10.1126/sciadv.abf5567
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/sciadv.abf5567
Verlag, lizenzpflichtig, Volltext: https://advances.sciencemag.org/content/7/13/eabf5567
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Author Notes:Laura Bernal, Pamela Sotelo-Hitschfeld, Christine König, Viktor Sinica, Amanda Wyatt, Zoltan Winter, Alexander Hein, Filip Touska, Susanne Reinhardt, Aaron Tragl, Ricardo Kusuda, Philipp Wartenberg, Allen Sclaroff, John D. Pfeifer, Fabien Ectors, Andreas Dahl, Marc Freichel, Viktorie Vlachova, Sebastian Brauchi, Carolina Roza, Ulrich Boehm, David E. Clapham, Jochen K. Lennerz, Katharina Zimmermann
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Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms by Phelan, Kevin (Author) , Shwe, U. Thaung (Author) , Abramowitz, Joel (Author) , Wu, Hong (Author) , Rhee, Sung W. (Author) , Howell, Matthew D. (Author) , Gottschall, Paul E. (Author) , Freichel, Marc (Author) , Flockerzi, Veit (Author) , Birnbaumer, Lutz (Author) , Zheng, Fang (Author) ,


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