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Long-term depression of C-fibre-evoked spinal field potentials by stimulation of primary afferent Aδ-fibres in the adult rat

Long-term potentiation (LTP) of spinal C-fibre-evoked field potentials can be induced by brief electrical stimulation of afferent C-fibres, by natural noxious stimulation of skin or by acute nerve injury. Here, we report that in urethane anaesthetized, adult rats prolonged high frequency burst stimu...

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Main Authors: Liu, Xianguo (Author) , Morton, C. R. (Author) , Azkue, J. J. (Author) , Zimmermann, M. (Author) , Sandkühler, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: 1998
In: European journal of neuroscience
Year: 1998, Volume: 10, Issue: 10, Pages: 3069-3075
ISSN:1460-9568
DOI:https://doi.org/10.1046/j.1460-9568.1998.00310.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1046/j.1460-9568.1998.00310.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1460-9568.1998.00310.x
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Author Notes:X.-G. Liu, C.R. Morton, J.J. Azkue, M. Zimmermann, J. Sandkühler
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Summary:Long-term potentiation (LTP) of spinal C-fibre-evoked field potentials can be induced by brief electrical stimulation of afferent C-fibres, by natural noxious stimulation of skin or by acute nerve injury. Here, we report that in urethane anaesthetized, adult rats prolonged high frequency burst stimulation of the sciatic nerve at Aδ-fibre strength produced long-term depression (LTD) of C-fibre-evoked field potentials, and also depressed the increased amplitudes of C-fibre-evoked field potentials recorded after LTP had been established (depotentiation). Electrical stimulation of Aβ-fibres failed to induce LTD or depotentiation. In spinalized rats, prolonged Aδ-fibre conditioning stimulation induced LTP rather than LTD of C-fibre-evoked field potentials. Thus, tonic descending inhibition may determine the direction of plastic changes in C-fibre-mediated synaptic transmission. Spinal application of the N-methyl-d-aspartic acid receptor antagonist D-APV blocked induction of LTD in intact rats and LTP in spinalized rats. The presently described LTD and the depotentiation of established LTP of C-fibre-evoked field potentials in spinal dorsal horn may underlie some forms of prolonged analgesia induced by peripheral nerve stimulation procedures.
Item Description:Published: 25 December 2001
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Physical Description:Online Resource
ISSN:1460-9568
DOI:https://doi.org/10.1046/j.1460-9568.1998.00310.x

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