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Differential actions of spinal analgesics on mono-versus polysynaptic Aδ-fibre-evoked field potentials in superficial spinal dorsal horn in vitro

Processing of nociceptive information can be modulated at various levels in spinal cord that may range from changes of neurotransmitter release from primary afferent Aδ- or C-fibres to excitability changes of spinal interneurones or motoneurones. The site and mechanism of action of spinal analgesics...

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Hauptverfasser: Ruscheweyh, Ruth (VerfasserIn) , Sandkühler, Jürgen (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 2000
In: Pain
Year: 2000, Jahrgang: 88, Heft: 1, Pages: 97-108
ISSN:1872-6623
DOI:10.1016/S0304-3959(00)00325-0
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0304-3959(00)00325-0
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/pain/Fulltext/2000/10010/Differential_actions_of_spinal_analgesics_on.12.aspx
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Verfasserangaben:Ruth Ruscheweyh, Jürgen Sandkühler
Beschreibung
Zusammenfassung:Processing of nociceptive information can be modulated at various levels in spinal cord that may range from changes of neurotransmitter release from primary afferent Aδ- or C-fibres to excitability changes of spinal interneurones or motoneurones. The site and mechanism of action of spinal analgesics has been assessed with a number of in vivo and in vitro methods with sometimes conflicting results. Here, we have used transverse spinal cord slices with attached dorsal roots to simultaneously record mono- and polysynaptic Aδ-fibre-evoked field potentials in superficial spinal dorsal horn. Two classical spinal analgesics, morphine and clonidine, and the metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) differentially affected mono- and polysynaptic Aδ-fibre-evoked transmission in spinal dorsal horn. Polysynaptic responses were dose-dependently inhibited while the monosynaptic response remained unaffected. These results suggest that spinal analgesics may preferentially affect polysynaptic but not monosynaptic Aδ-fibre-evoked responses in superficial spinal dorsal horn.
Beschreibung:Gesehen am 04.05.2021
Beschreibung:Online Resource
ISSN:1872-6623
DOI:10.1016/S0304-3959(00)00325-0

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