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αvβ3-specific gold nanoparticles for fluorescence imaging of tumor angiogenesis

This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via an external X-ray irradiation source. The AuNPs w...

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Bibliographic Details
Main Authors: Pretze, Marc (Author) , Kiedrowski, Valeska von (Author) , Runge, Roswitha (Author) , Freudenberg, Robert (Author) , Hübner, René (Author) , Davarci, Güllü (Author) , Schirrmacher, Ralf (Author) , Wängler, Carmen (Author) , Wängler, Björn (Author)
Format: Article (Journal)
Language:English
Published: 8 January 2021
In: Nanomaterials
Year: 2021, Volume: 11, Issue: 1, Pages: 1-29
ISSN:2079-4991
DOI:10.3390/nano11010138
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/nano11010138
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2079-4991/11/1/138
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Author Notes:Marc Pretze, Valeska von Kiedrowski, Roswitha Runge, Robert Freudenberg, René Hübner, Güllü Davarci, Ralf Schirrmacher, Carmen Wängler and Björn Wängler
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Summary:This paper reports on the development of tumor-specific gold nanoparticles (AuNPs) as theranostic tools intended for target accumulation and the detection of tumor angiogenesis via optical imaging (OI) before therapy is performed, being initiated via an external X-ray irradiation source. The AuNPs were decorated with a near-infrared dye, and RGD peptides as the tumor targeting vector for αvβ3-integrin, which is overexpressed in tissue with high tumor angiogenesis. The AuNPs were evaluated in an optical imaging setting in vitro and in vivo exhibiting favorable diagnostic properties with regards to tumor cell accumulation, biodistribution, and clearance. Furthermore, the therapeutic properties of the AuNPs were evaluated in vitro on pUC19 DNA and on A431 cells concerning acute and long-term toxicity, indicating that these AuNPs could be useful as radiosensitizers in therapeutic concepts in the future.
Item Description:Gesehen am 04.05.2021
Physical Description:Online Resource
ISSN:2079-4991
DOI:10.3390/nano11010138

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