Cover Image

Early prognostic performance of miR155-5p monitoring for the risk of rejection: Logistic regression with a population pharmacokinetic approach in adult kidney transplant patients

Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONM...

Full description

Saved in:
Bibliographic Details
Main Authors: Quintairos, Luis (Author) , Colom, Helena (Author) , Millán, Olga (Author) , Fortuna, Virginia (Author) , Espinosa, Cristina (Author) , Guirado, Lluis (Author) , Budde, Klemens (Author) , Sommerer, Claudia (Author) , Lizana, Ana (Author) , López-Púa, Yolanda (Author) , Brunet, Mercè (Author)
Format: Article (Journal)
Language:English
Published: January 22, 2021
In: PLOS ONE
Year: 2021, Volume: 16, Issue: 1, Pages: 1-20
ISSN:1932-6203
DOI:10.1371/journal.pone.0245880
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0245880
Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0245880
Get full text
Author Notes:Luis Quintairos, Helena Colom, Olga Millán, Virginia Fortuna, Cristina Espinosa, Lluis Guirado, Klemens Budde, Claudia Sommerer, Ana Lizana, Yolanda López-Púa, Mercè Brunet
Description
Summary:Previous results from our group and others have shown that urinary pellet expression of miR155-5p and urinary CXCL-10 production could play a key role in the prognosis and diagnosis of acute rejection (AR) in kidney transplantation patients. Here, a logistic regression model was developed using NONMEM to quantify the relationships of miR155-5p urinary expression, CXCL-10 urinary concentration and tacrolimus and mycophenolic acid (MPA) exposure with the probability of AR in adult kidney transplant patients during the early post-transplant period. Owing to the contribution of therapeutic drug monitoring to achieving target exposure, neither tacrolimus nor MPA cumulative exposure was identified as a predictor of AR in the studied population. Even though CXCL-10 urinary concentration showed a trend, its effect on AR was not significant. In contrast, urinary miR155-5p expression was prognostic of clinical outcome. Monitoring miR155-5p urinary pellet expression together with immunosuppressive drug exposure could be very useful during routine clinical practice to identify patients with a potential high risk of rejection at the early stages of the post-transplant period. This early risk assessment would allow for the optimization of treatment and improved prevention of AR.
Item Description:Gesehen am 04.05.2021
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0245880

Similar Items