Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain
The regulation of programmed cell death in the nervous system of vertebrates is a complex mechanism aimed to remove superfluous or damaged cells. Epileptic seizures can lead to an activation of pathways resulting in neuronal cell death. B-vitamins might have a neuroprotective potential reducing cell...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 2010
|
| In: |
Journal of molecular neuroscience
Year: 2009, Volume: 41, Issue: 1, Pages: 74-79 |
| ISSN: | 1559-1166 |
| DOI: | 10.1007/s12031-009-9286-4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s12031-009-9286-4
|
| Author Notes: | Tamer Rabie, Wolfgang Mühlhofer, Thomas Bruckner, Anna Schwab, Alexander T. Bauer, Manfred Zimmermann, Dieter Bonke, Hugo H. Marti, Johannes Schenkel |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1757062165 | ||
| 003 | DE-627 | ||
| 005 | 20240413193341.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210504r20102009xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s12031-009-9286-4 |2 doi | |
| 035 | |a (DE-627)1757062165 | ||
| 035 | |a (DE-599)KXP1757062165 | ||
| 035 | |a (OCoLC)1341407836 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Rabie, Tamer |d 1975- |e VerfasserIn |0 (DE-588)130291994 |0 (DE-627)497645033 |0 (DE-576)298109816 |4 aut | |
| 245 | 1 | 0 | |a Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain |c Tamer Rabie, Wolfgang Mühlhofer, Thomas Bruckner, Anna Schwab, Alexander T. Bauer, Manfred Zimmermann, Dieter Bonke, Hugo H. Marti, Johannes Schenkel |
| 264 | 1 | |c May 2010 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 24 September 2009 | ||
| 500 | |a Gesehen am 04.05.2021 | ||
| 520 | |a The regulation of programmed cell death in the nervous system of vertebrates is a complex mechanism aimed to remove superfluous or damaged cells. Epileptic seizures can lead to an activation of pathways resulting in neuronal cell death. B-vitamins might have a neuroprotective potential reducing cell death following appropriate stimulation. Here, the role of the B-vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamine) was investigated in a mouse model of experimental epilepsy induced by kainate. B-vitamin pre-treated animals showed a significantly reduced epileptic score during the first 15 min after kainate injection. The molecular response to kainate showed a bi-phased time course with early induction of Bcl-2 expression within 12 h and a second induction after 7 days of kainate exposure. B-vitamin pre-treatment resulted in significant higher Bcl-2 expression in control animals (no kainate) and at 12 h within the early phase. Bcl-2 expression was not affected by B-vitamins within the second phase. BAX expression was not significantly influenced during the whole experiment. Three days after kainate stimulation, the number of TdT-mediated dUTP-biotin nick end labeling-positive cells in the hippocampal region was lower in B-vitamin-treated animals. Therefore, B-vitamin pre-treatment may attenuate the response to epileptic stimulation. | ||
| 534 | |c 2009 | ||
| 700 | 1 | |a Mühlhofer, Wolfgang Gerhard |d 1984- |e VerfasserIn |0 (DE-588)142254967 |0 (DE-627)634797506 |0 (DE-576)329581414 |4 aut | |
| 700 | 1 | |a Bruckner, Thomas |d 1956- |e VerfasserIn |0 (DE-588)136046215 |0 (DE-627)574429298 |0 (DE-576)300798768 |4 aut | |
| 700 | 1 | |a Schwab, Anna |d 1977- |e VerfasserIn |0 (DE-588)132551594 |0 (DE-627)52364101X |0 (DE-576)299220338 |4 aut | |
| 700 | 1 | |a Bauer, Alexander |d 1978- |e VerfasserIn |0 (DE-588)143496425 |0 (DE-627)646577778 |0 (DE-576)337385572 |4 aut | |
| 700 | 1 | |a Zimmermann, Manfred |d 1933-2024 |e VerfasserIn |0 (DE-588)103524103X |0 (DE-627)747076731 |0 (DE-576)382843673 |4 aut | |
| 700 | 1 | |a Bonke, Dieter |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marti, Hugo |e VerfasserIn |0 (DE-588)1137018356 |0 (DE-627)893957208 |0 (DE-576)491045468 |4 aut | |
| 700 | 1 | |a Schenkel, Johannes |d 1954- |e VerfasserIn |0 (DE-588)115545239 |0 (DE-627)077320107 |0 (DE-576)28994158X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of molecular neuroscience |d New York, NY : Springer, 1998 |g 41(2010), 1, Seite 74-79 |h Online-Ressource |w (DE-627)342319477 |w (DE-600)2071508-0 |w (DE-576)306829991 |x 1559-1166 |7 nnas |a Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain |
| 773 | 1 | 8 | |g volume:41 |g year:2010 |g number:1 |g pages:74-79 |g extent:6 |a Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s12031-009-9286-4 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210504 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 115545239 |a Schenkel, Johannes |m 115545239:Schenkel, Johannes |d 50000 |e 50000PS115545239 |k 0/50000/ |p 9 |y j | ||
| 998 | |g 1137018356 |a Marti, Hugo |m 1137018356:Marti, Hugo |d 50000 |d 53200 |e 50000PM1137018356 |e 53200PM1137018356 |k 0/50000/ |k 1/50000/53200/ |p 8 | ||
| 998 | |g 103524103X |a Zimmermann, Manfred |m 103524103X:Zimmermann, Manfred |d 50000 |e 50000PZ103524103X |k 0/50000/ |p 6 | ||
| 998 | |g 143496425 |a Bauer, Alexander |m 143496425:Bauer, Alexander |d 50000 |e 50000PB143496425 |k 0/50000/ |p 5 | ||
| 998 | |g 136046215 |a Bruckner, Thomas |m 136046215:Bruckner, Thomas |d 910000 |d 999701 |e 910000PB136046215 |e 999701PB136046215 |k 0/910000/ |k 1/910000/999701/ |p 3 | ||
| 998 | |g 142254967 |a Mühlhofer, Wolfgang Gerhard |m 142254967:Mühlhofer, Wolfgang Gerhard |d 50000 |e 50000PM142254967 |k 0/50000/ |p 2 | ||
| 999 | |a KXP-PPN1757062165 |e 3922762131 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Tamer Rabie, Wolfgang Mühlhofer, Thomas Bruckner, Anna Schwab, Alexander T. Bauer, Manfred Zimmermann, Dieter Bonke, Hugo H. Marti, Johannes Schenkel"]},"title":[{"title_sort":"Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain","title":"Transient protective effect of B-vitamins in experimental epilepsy in the mouse brain"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"roleDisplay":"VerfasserIn","role":"aut","display":"Rabie, Tamer","given":"Tamer","family":"Rabie"},{"family":"Mühlhofer","given":"Wolfgang Gerhard","display":"Mühlhofer, Wolfgang Gerhard","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Bruckner","given":"Thomas","display":"Bruckner, Thomas","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Anna","family":"Schwab","role":"aut","roleDisplay":"VerfasserIn","display":"Schwab, Anna"},{"family":"Bauer","given":"Alexander","display":"Bauer, Alexander","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Manfred","family":"Zimmermann","display":"Zimmermann, Manfred","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Bonke, Dieter","family":"Bonke","given":"Dieter"},{"family":"Marti","given":"Hugo","roleDisplay":"VerfasserIn","role":"aut","display":"Marti, Hugo"},{"family":"Schenkel","given":"Johannes","roleDisplay":"VerfasserIn","role":"aut","display":"Schenkel, Johannes"}],"note":["Published online: 24 September 2009","Gesehen am 04.05.2021"],"recId":"1757062165","language":["eng"],"physDesc":[{"extent":"6 S."}],"relHost":[{"part":{"extent":"6","year":"2010","pages":"74-79","volume":"41","issue":"1","text":"41(2010), 1, Seite 74-79"},"origin":[{"dateIssuedDisp":"1998-","dateIssuedKey":"1998","publisher":"Springer ; Humana Press","publisherPlace":"New York, NY ; Totowa, NJ"}],"id":{"issn":["1559-1166"],"eki":["342319477"],"zdb":["2071508-0"]},"titleAlt":[{"title":"JMN online"}],"pubHistory":["Nachgewiesen 11.1998 -"],"title":[{"subtitle":"JMN online","title_sort":"Journal of molecular neuroscience","title":"Journal of molecular neuroscience"}],"recId":"342319477","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 15.04.14"],"disp":"Transient protective effect of B-vitamins in experimental epilepsy in the mouse brainJournal of molecular neuroscience","type":{"media":"Online-Ressource","bibl":"periodical"}}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"May 2010"}],"id":{"doi":["10.1007/s12031-009-9286-4"],"eki":["1757062165"]}} | ||
| SRT | |a RABIETAMERTRANSIENTP2010 | ||