Effects of chronic isovolaemic haemodilution on regional cerebral blood flow in conscious rats
Background and objective: - Acute isovolaemic haemodilution increases local and mean cerebral blood flow. It is not known whether a single haemodilution has a short-term effect only or whether it affects cerebral perfusion over a longer time period. In the present study, local and mean cerebral blo...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[2004]
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| In: |
European journal of anaesthesiology
Year: 2004, Volume: 21, Issue: 1, Pages: 53-59 |
| ISSN: | 1365-2346 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/ejanaesthesiology/fulltext/2004/01000/effects_of_chronic_isovolaemic_haemodilution_on.9.aspx
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| Author Notes: | T. Frietsch, C. Lenz, W. Kuschinsky, K.F. Waschke |
MARC
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| 245 | 1 | 0 | |a Effects of chronic isovolaemic haemodilution on regional cerebral blood flow in conscious rats |c T. Frietsch, C. Lenz, W. Kuschinsky, K.F. Waschke |
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| 520 | |a Background and objective: - Acute isovolaemic haemodilution increases local and mean cerebral blood flow. It is not known whether a single haemodilution has a short-term effect only or whether it affects cerebral perfusion over a longer time period. In the present study, local and mean cerebral blood flow were determined in conscious rats after a 4, 24 and 48 h period following one-time haemodilution. - Methods: - Thirty-six rats were randomized to three untreated sham groups and three groups of haemodilution (4, 24 or 48 h, n = 6 for each group). Isovolaemic haemodilution with albumin 5% aimed to a target haematocrit of 0.2. Local cerebral blood flow was measured in 38 brain regions by the iodo-[14C]antipyrine method in conscious normothermic rats. - Results: - Isovolaemic haemodilution reduced haematocrit from 0.44 to 0.20. During the following 24 and 48 h periods, haematocrit remained low (0.22 and 0.21). Mean cerebral blood flow was similar in untreated sham groups (88 ± 12 after 4 h, 92 ± 11 after 24 h, 96 ± 10 mL 100 g−1 min−1 after 48 h). Haemodilution increased mean cerebral blood flow after 4 h (184 ± 11 mL 100 g−1 min−1), after 24 h (153 ± 13 mL 100 g−1 min−1) and 48 h (149 ± 15 mL 100 g−1 min−1) (P ≤ 0.05). Local cerebral blood flow increased in all 38 structures after 4 h haemodilution but decreased with time in six of 38 brain structures after 24 h and in 15 regions after 48 h (P ≤ 0.05). - Conclusions: - A single one-time haemodilution increased mean cerebral blood flow for 2 days. However, local adaptation of cerebral blood flow to a chronic low haematocrit occurred but was heterogeneous within the brain. | ||
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