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Efficacy of sonothrombolysis in a rat model of embolic ischemic stroke

The key goal in the treatment of acute ischemic stroke is fast vessel recanalization. Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is efficient in humans but mean time for recanalization is within hours. Ultrasound bio-effects has been shown to facilitate rt-PA mediated thrombo...

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Main Authors: Daffertshofer, Michael (Author) , Huang, Z. (Author) , Fatar, Marc (Author) , Popolo, M. (Author) , Schröck, Helmut (Author) , Kuschinsky, Wolfgang (Author) , Moskowitz, M. A. (Author) , Hennerici, Michael G. (Author)
Format: Article (Journal)
Language:English
Published: 15 April 2004
In: Neuroscience letters
Year: 2004, Volume: 361, Issue: 1, Pages: 115-119
ISSN:1872-7972
DOI:10.1016/j.neulet.2004.02.003
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.neulet.2004.02.003
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304394004001363
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Author Notes:M. Daffertshofer, Z. Huang, M. Fatar, M. Popolo, H. Schroeck, W. Kuschinsky, M.A. Moskowitz, M.G. Hennerici

MARC

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520 |a The key goal in the treatment of acute ischemic stroke is fast vessel recanalization. Thrombolysis with recombinant tissue plasminogen activator (rt-PA) is efficient in humans but mean time for recanalization is within hours. Ultrasound bio-effects has been shown to facilitate rt-PA mediated thrombolysis in peripheral arteries. We used an embolic stroke model in the rat. In all rats we induced an ischemic stroke by a selective occlusion of the middle cerebral artery with whole blood clots. From an entire collective of 54 rats 47 completed the protocol (n=7 died early). Four different groups (no treatment n=6; full dose rt-PA treatment only [10 mg/kg per body weight] n=14, half dose rt-PA treatment plus ultrasound n=10, and full dose rt-PA treatment plus ultrasound n=17) were investigated. We found a significant reduction of absolute as well as relative infarct volume in the full dose rt-PA plus ultrasound group (81±72 mm3; P<0.05) in comparison to untreated rats (253±159 mm3; P<0.05) as well as in comparison to rats treated with full dose rt-PA only (167±91 mm3; P<0.05). There were five intracranial bleedings giving a bleeding rate of 9.3%. In summary: ultrasound treatment in addition to rt-PA is more effective than single rt-PA treatment in reducing infarct volume and safe with regard to bleeding. 
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