Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB
Naïve CD4+ T cells differentiate into effector T helper 1 (Th1) or Th2 cells, which are classified by their specific set of cytokines. Here we demonstrate that loss of JunB in in vitro polarized Th2 cells led to a dysregulated expression of the Th2-specific cytokines IL-4 and IL-5. These cells prod...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1 December 2002
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| In: |
The EMBO journal
Year: 2002, Jahrgang: 21, Heft: 23, Pages: 6321-6329 |
| ISSN: | 1460-2075 |
| DOI: | 10.1093/emboj/cdf648 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/emboj/cdf648 Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1093/emboj/cdf648 
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| Verfasserangaben: | Bettina Hartenstein, Sibylle Teurich, Jochen Hess, Johannes Schenkel, Marina Schorpp-Kistner and Peter Angel |
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| 520 | |a Naïve CD4+ T cells differentiate into effector T helper 1 (Th1) or Th2 cells, which are classified by their specific set of cytokines. Here we demonstrate that loss of JunB in in vitro polarized Th2 cells led to a dysregulated expression of the Th2-specific cytokines IL-4 and IL-5. These cells produce IFN-? and express T-bet, the key regulator of Th1 cells. In line with the essential role of Th2 cells in the pathogenesis of allergic asthma, mice with JunB-deficient CD4+ T cells exhibited an impaired allergen-induced airway inflammation. This study demonstrates novel functions of JunB in the development of Th2 effector cells, for a normal Th2 cytokine expression pattern and for a complete Th2-dependent immune response in mice. | ||
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