Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials

Frailty and adverse drug effects are linked in the fact that polypharmacy is correlated with the severity of frailty; however, a causal relation has not been proven in older people with clinically manifest frailty.

Bibliographic Details

Main Authors:	Pazan, Farhad (Author) , Petrovic, Mirko (Author) , Cherubini, Antonio (Author) , Onder, Graziano (Author) , Cruz-Jentoft, Alfonso J. (Author) , Denkinger, Michael D. (Author) , van der Cammen, Tischa J. M. (Author) , Stevenson, Jennifer M. (Author) , Ibrahim, Kinda (Author) , Rajkumar, Chakravarthi (Author) , Bakken, Marit Stordal (Author) , Baeyens, Jean-Pierre (Author) , Crome, Peter (Author) , Frühwald, Thomas (Author) , Gallaghar, Paul (Author) , Guðmundsson, Adalsteinn (Author) , Knol, Wilma (Author) , O’Mahony, Denis (Author) , Pilotto, Alberto (Author) , Rönnemaa, Elina (Author) , Serra-Rexach, José Antonio (Author) , Soulis, George (Author) , van Marum, Rob J. (Author) , Ziere, Gijsbertus (Author) , Mair, Alpana (Author) , Burkhardt, Heinrich (Author) , Neumann-Podczaska, Agnieszka (Author) , Wieczorowska-Tobis, Katarzyna (Author) , Fernandes, Marilia Andreia (Author) , Gruner, Heidi (Author) , Dallmeier, Dhayana (Author) , Beuscart, Jean-Baptiste (Author) , van der Velde, Nathalie (Author) , Wehling, Martin (Author)
Format:	Article (Journal)
Language:	English
Published:	2021
In:	European journal of clinical pharmacology Year: 2021, Volume: 77, Issue: 1, Pages: 1-12
ISSN:	1432-1041
DOI:	10.1007/s00228-020-02951-8
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00228-020-02951-8
Author Notes:	Farhad Pazan, Mirko Petrovic, Antonio Cherubini, Graziano Onder, Alfonso J. Cruz-Jentoft, Michael Denkinger, Tischa J. M. van der Cammen, Jennifer M. Stevenson, Kinda Ibrahim, Chakravarthi Rajkumar, Marit Stordal Bakken, Jean-Pierre Baeyens, Peter Crome, Thomas Frühwald, Paul Gallaghar, Adalsteinn Guðmundsson, Wilma Knol, Denis O’Mahony, Alberto Pilotto, Elina Rönnemaa, José Antonio Serra-Rexach, George Soulis, Rob J. van Marum, Gijsbertus Ziere, Alpana Mair, Heinrich Burkhardt, Agnieszka Neumann-Podczaska, Katarzyna Wieczorowska-Tobis, Marilia Andreia Fernandes, Heidi Gruner, Dhayana Dallmeier, Jean-Baptiste Beuscart, Nathalie van der Velde, Martin Wehling