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Fatigue following radiotherapy of low-risk early breast cancer - a randomized controlled trial of intraoperative electron radiotherapy versus standard hypofractionated whole-breast radiotherapy: the COSMOPOLITAN trial (NCT03838419)

Fatigue is one of the most common and distressing side-effects of breast cancer radiotherapy. According to current guidelines, accelerated partial breast irradiation (APBI) may be considered as an alternative treatment option for women with early-stage low-risk breast cancer. One method for APBI is...

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Main Authors: Forster, Tobias (Author) , Jäkel, Cornelia (Author) , Akbaba, Sati (Author) , Krug, David (Author) , Krempien, Robert (Author) , Uhl, Matthias (Author) , Häfner, Matthias (Author) , König, Laila (Author) , Körber, Stefan A. (Author) , Harrabi, Semi B. (Author) , Bernhardt, Denise (Author) , Behnisch, Rouven (Author) , Krisam, Johannes (Author) , Hennigs, André (Author) , Sohn, Christof (Author) , Heil, Jörg (Author) , Debus, Jürgen (Author) , Hörner-Rieber, Juliane (Author)
Format: Article (Journal)
Language:English
Published: 01 June 2020
In: Radiation oncology
Year: 2020, Volume: 15, Pages: 1-10
ISSN:1748-717X
DOI:10.1186/s13014-020-01581-9
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13014-020-01581-9
Verlag, lizenzpflichtig, Volltext: https://ro-journal.biomedcentral.com/articles/10.1186/s13014-020-01581-9
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Author Notes:Tobias Forster, Cornelia Jäkel, Sati Akbaba, David Krug, Robert Krempien, Matthias Uhl, Matthias Felix Häfner, Laila König, Stefan Alexander Koerber, Semi Harrabi, Denise Bernhardt, Rouven Behnisch, Johannes Krisam, Andre Hennigs, Christof Sohn, Jörg Heil, Jürgen Debus and Juliane Hörner-Rieber
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Summary:Fatigue is one of the most common and distressing side-effects of breast cancer radiotherapy. According to current guidelines, accelerated partial breast irradiation (APBI) may be considered as an alternative treatment option for women with early-stage low-risk breast cancer. One method for APBI is single-dose intraoperative radiotherapy (IORT) applied directly to the tumor bed during breast conserving surgery (BCS). The COSMOPOLITAN trial therefore aims to analyze the intensity of fatigue following single-shot IORT with electrons (IOERT) compared to conventional hypofractionated whole breast irradiation (WBI) in low risk early breast cancer patients.
Item Description:Gesehen am 10.05.2021
Physical Description:Online Resource
ISSN:1748-717X
DOI:10.1186/s13014-020-01581-9

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