Associations between NT-proBNP and psychosocial factors in patients with chronic systolic heart failure
Objective - B-type natriuretic peptides (BNPs) and their biologically inactive N-terminal parts, namely, NT-proBNPs, are used for diagnostic and prognostic purposes in patients with chronic heart failure (CHF). Associations of BNPs and NT-proBNPs with emotional factors may exist. As depressive and a...
Gespeichert in:
| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2 February 2021
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| In: |
Journal of psychosomatic research
Year: 2021, Jahrgang: 143, Pages: 1-7 |
| ISSN: | 1879-1360 |
| DOI: | 10.1016/j.jpsychores.2021.110385 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jpsychores.2021.110385 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0022399921000301 
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| Verfasserangaben: | Thomas Müller-Tasch, Katja Krug, Frank Peters-Klimm |
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| 245 | 1 | 0 | |a Associations between NT-proBNP and psychosocial factors in patients with chronic systolic heart failure |c Thomas Müller-Tasch, Katja Krug, Frank Peters-Klimm |
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| 520 | |a Objective - B-type natriuretic peptides (BNPs) and their biologically inactive N-terminal parts, namely, NT-proBNPs, are used for diagnostic and prognostic purposes in patients with chronic heart failure (CHF). Associations of BNPs and NT-proBNPs with emotional factors may exist. As depressive and anxious comorbidities and decreases in quality of life (QoL) are common in CHF patients, we explored the associations between NT-proBNP and depression, anxiety, and QoL in patients with CHF using cross-sectional and longitudinal analyses. - Methods - We used baseline and one-year follow-up NT-proBNP measurements and sociodemographic and clinical data from 180 patients with systolic CHF from a case management study. Depression was assessed with the Patient Health Questionnaire 9 (PHQ-9), anxiety was assessed with the Generalized Anxiety Disorder Scale 7 (GAD-7), and QoL was determined using the Short Form 36 (SF-36) health survey. - Results - Univariate correlation analyses showed significant negative associations between NT-proBNP and the scores of four out of eight QoL domains (range: r = −0.159 to −0.285, p = .042 to 0.001) of the SF-36 but not between NT-proBNP and depression and anxiety scores. In cross-sectional and longitudinal multivariate regression analyses, no significant associations between NT-proBNP and psychometric variables were found. - Conclusion - In patients with stable, chronic systolic heart failure, only weak relations between NT-proBNP and QoL exist, but no relations between NT-proBNP and depression and anxiety were found. These findings are placed in the current research context of this topic. Implications for future experimental studies are discussed. | ||
| 650 | 4 | |a Anxiety | |
| 650 | 4 | |a Chronic heart failure | |
| 650 | 4 | |a Depression | |
| 650 | 4 | |a Natriuretic peptides | |
| 650 | 4 | |a Quality of life | |
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| 700 | 1 | |a Peters-Klimm, Frank |d 1970- |e VerfasserIn |0 (DE-588)1049160819 |0 (DE-627)781265215 |0 (DE-576)348126530 |4 aut | |
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