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Experiences with IL-1 blockade in systemic juvenile idiopathic arthritis: data from the German AID-registry

Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with dysregulation of the innate immune system driven by cytokines. A major role is ascribed to interleukin-1β (IL-1β), supporting the autoinflammatory character of the disease and offering an effective blocking mechanism for treatme...

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Main Authors: Lainka, Elke Maria (Author) , Baehr, Melanie (Author) , Raszka, Bernadette (Author) , Haas, Johannes-Peter (Author) , Hügle, Boris (Author) , Fischer, Nadine (Author) , Foell, Dirk (Author) , Hinze, Claas (Author) , Weissbarth-Riedel, Elisabeth (Author) , Kallinich, Tilmann (Author) , Horneff, Gerd (Author) , Windschall, Daniel (Author) , Lilienthal, Eggert (Author) , Niehues, Tim (Author) , Neudorf, Ulrich (Author) , Berendes, Rainer (Author) , Küster, Rolf-Michael (Author) , Oommen, Prasad Thomas (Author) , Rietschel, Christoph (Author) , Lutz, Thomas (Author) , Weller-Heinemann, Frank (Author) , Tenbrock, Klaus (Author) , Heubner, Georg Leonhard (Author) , Klotsche, Jens (Author) , Wittkowski, Helmut (Author)
Format: Article (Journal)
Language:English
Published: 22 March 2021
In: Pediatric rheumatology
Year: 2021, Volume: 19, Pages: 1-12
ISSN:1546-0096
DOI:10.1186/s12969-021-00510-8
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12969-021-00510-8
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Author Notes:Elke Lainka, Melanie Baehr, Bernadette Raszka, Johannes-Peter Haas, Boris Hügle, Nadine Fischer, Dirk Foell, Claas Hinze, Elisabeth Weissbarth-Riedel, Tilmann Kallinich, Gerd Horneff, Daniel Windschall, Eggert Lilienthal, Tim Niehues, Ulrich Neudorf, Rainer Berendes, Rolf-Michael Küster, Prasad Thomas Oommen, Christoph Rietschel, Thomas Lutz, Frank Weller-Heinemann, Klaus Tenbrock, Georg Leonhard Heubner, Jens Klotsche and Helmut Wittkowski
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Summary:Systemic juvenile idiopathic arthritis (sJIA) is a complex disease with dysregulation of the innate immune system driven by cytokines. A major role is ascribed to interleukin-1β (IL-1β), supporting the autoinflammatory character of the disease and offering an effective blocking mechanism for treatment. Here we present clinical practice data from the German AID-registry for patients treated with IL-1 inhibition (IL-1i).
Item Description:Gesehen am 12.05.2021
Physical Description:Online Resource
ISSN:1546-0096
DOI:10.1186/s12969-021-00510-8

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