Cover Image

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor the tuberous sclerosis complex (...

Full description

Saved in:
Bibliographic Details
Main Authors: Prentzell, Mirja Tamara (Author) , Rehbein, Ulrike (Author) , Cadena Sandoval, Marti (Author) , De Meulemeester, Ann-Sofie (Author) , Baumeister, Ralf (Author) , Brohée, Laura (Author) , Berdel, Bianca (Author) , Bockwoldt, Mathias (Author) , Carroll, Bernadette (Author) , Chowdhury, Suvagata Roy (Author) , Deimling, Andreas von (Author) , Demetriades, Constantinos (Author) , Figlia, Gianluca (Author) , de Araujo, Mariana Eca Guimaraes (Author) , Heberle, Alexander M. (Author) , Heiland, Ines (Author) , Holzwarth, Birgit (Author) , Huber, Lukas A. (Author) , Jaworski, Jacek (Author) , Kedra, Magdalena (Author) , Kern, Katharina (Author) , Kopach, Andrii (Author) , Korolchuk, Viktor I. (Author) , van 't Land-Kuper, Ineke (Author) , Macias, Matylda (Author) , Nellist, Mark (Author) , Palm, Wilhelm (Author) , Pusch, Stefan (Author) , Ramos Pittol, Jose Miguel (Author) , Reil, Michèle (Author) , Reintjes, Anja (Author) , Reuter, Friederike (Author) , Sampson, Julian R. (Author) , Scheldeman, Chloë (Author) , Siekierska, Aleksandra (Author) , Stefan, Eduard (Author) , Teleman, Aurelio A. (Author) , Opitz, Christiane (Author)
Format: Article (Journal)
Language:English
Published: 25 January 2021
In: Cell
Year: 2021, Volume: 184, Issue: 3, Pages: 655-674
ISSN:1097-4172
DOI:10.1016/j.cell.2020.12.024
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.cell.2020.12.024
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0092867420316949
Get full text
Author Notes:Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van 't Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michèle Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloë Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck

MARC

LEADER 00000caa a2200000 c 4500
001 1757716661
003 DE-627
005 20241230014044.0
007 cr uuu---uuuuu
008 210512s2021 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.cell.2020.12.024  |2 doi 
035 |a (DE-627)1757716661 
035 |a (DE-599)KXP1757716661 
035 |a (OCoLC)1341408815 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Prentzell, Mirja Tamara  |d 1985-  |e VerfasserIn  |0 (DE-588)1161746072  |0 (DE-627)1025196643  |0 (DE-576)506839869  |4 aut 
245 1 0 |a G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling  |c Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van 't Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michèle Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloë Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck 
246 3 0 |a three one 
264 1 |c 25 January 2021 
300 |a 20 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 12.05.2021 
520 |a Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively) are widely recognized as core components of stress granules (SGs). We report that G3BPs reside at the cytoplasmic surface of lysosomes. They act in a non-redundant manner to anchor the tuberous sclerosis complex (TSC) protein complex to lysosomes and suppress activation of the metabolic master regulator mechanistic target of rapamycin complex 1 (mTORC1) by amino acids and insulin. Like the TSC complex, G3BP1 deficiency elicits phenotypes related to mTORC1 hyperactivity. In the context of tumors, low G3BP1 levels enhance mTORC1-driven breast cancer cell motility and correlate with adverse outcomes in patients. Furthermore, G3bp1 inhibition in zebrafish disturbs neuronal development and function, leading to white matter heterotopia and neuronal hyperactivity. Thus, G3BPs are not only core components of SGs but also a key element of lysosomal TSC-mTORC1 signaling. 
650 4 |a cancer 
650 4 |a G3BP1 
650 4 |a G3BP2 
650 4 |a lysosome 
650 4 |a metabolism 
650 4 |a mTORC1 
650 4 |a neuronal function 
650 4 |a stress granule 
650 4 |a TSC complex 
700 1 |8 1\p  |a Rehbein, Ulrike  |d 1991-  |e VerfasserIn  |0 (DE-588)122557448X  |0 (DE-627)174528608X  |4 aut 
700 1 |a Cadena Sandoval, Marti  |e VerfasserIn  |4 aut 
700 1 |a De Meulemeester, Ann-Sofie  |e VerfasserIn  |4 aut 
700 1 |8 2\p  |a Baumeister, Ralf  |d 1961-  |e VerfasserIn  |0 (DE-588)172579600  |0 (DE-627)697514927  |0 (DE-576)133439305  |4 aut 
700 1 |a Brohée, Laura  |e VerfasserIn  |4 aut 
700 1 |a Berdel, Bianca  |e VerfasserIn  |4 aut 
700 1 |a Bockwoldt, Mathias  |e VerfasserIn  |4 aut 
700 1 |a Carroll, Bernadette  |e VerfasserIn  |4 aut 
700 1 |a Chowdhury, Suvagata Roy  |e VerfasserIn  |4 aut 
700 1 |a Deimling, Andreas von  |d 1959-  |e VerfasserIn  |0 (DE-588)103034115X  |0 (DE-627)735093946  |0 (DE-576)378138065  |4 aut 
700 1 |a Demetriades, Constantinos  |e VerfasserIn  |4 aut 
700 1 |a Figlia, Gianluca  |e VerfasserIn  |4 aut 
700 1 |a de Araujo, Mariana Eca Guimaraes  |e VerfasserIn  |4 aut 
700 1 |a Heberle, Alexander M.  |e VerfasserIn  |4 aut 
700 1 |a Heiland, Ines  |e VerfasserIn  |4 aut 
700 1 |a Holzwarth, Birgit  |e VerfasserIn  |4 aut 
700 1 |a Huber, Lukas A.  |e VerfasserIn  |4 aut 
700 1 |a Jaworski, Jacek  |e VerfasserIn  |4 aut 
700 1 |a Kedra, Magdalena  |e VerfasserIn  |4 aut 
700 1 |a Kern, Katharina  |e VerfasserIn  |4 aut 
700 1 |a Kopach, Andrii  |e VerfasserIn  |4 aut 
700 1 |a Korolchuk, Viktor I.  |e VerfasserIn  |4 aut 
700 1 |a van 't Land-Kuper, Ineke  |e VerfasserIn  |4 aut 
700 1 |a Macias, Matylda  |e VerfasserIn  |4 aut 
700 1 |a Nellist, Mark  |e VerfasserIn  |4 aut 
700 1 |a Palm, Wilhelm  |e VerfasserIn  |4 aut 
700 1 |a Pusch, Stefan  |e VerfasserIn  |4 aut 
700 1 |a Ramos Pittol, Jose Miguel  |e VerfasserIn  |4 aut 
700 1 |a Reil, Michèle  |e VerfasserIn  |4 aut 
700 1 |a Reintjes, Anja  |e VerfasserIn  |4 aut 
700 1 |a Reuter, Friederike  |e VerfasserIn  |4 aut 
700 1 |a Sampson, Julian R.  |e VerfasserIn  |4 aut 
700 1 |a Scheldeman, Chloë  |e VerfasserIn  |4 aut 
700 1 |a Siekierska, Aleksandra  |e VerfasserIn  |4 aut 
700 1 |a Stefan, Eduard  |e VerfasserIn  |4 aut 
700 1 |a Teleman, Aurelio A.  |d 1976-  |e VerfasserIn  |0 (DE-588)1155118294  |0 (DE-627)1016370121  |0 (DE-576)501431861  |4 aut 
700 1 |a Opitz, Christiane  |d 1979-  |e VerfasserIn  |0 (DE-588)132405121  |0 (DE-627)522675913  |0 (DE-576)299125041  |4 aut 
773 0 8 |i Enthalten in  |t Cell  |d [Cambridge, Mass.] : Cell Press, 1974  |g 184(2021,3), Seite 655-674, e1-e19, 47 Seiten  |h Online-Ressource  |w (DE-627)320416127  |w (DE-600)2001951-8  |w (DE-576)090881370  |x 1097-4172  |7 nnas  |a G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling 
773 1 8 |g volume:184  |g year:2021  |g number:3  |g pages:655-674  |g extent:20  |a G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling 
856 4 0 |u https://doi.org/10.1016/j.cell.2020.12.024  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0092867420316949  |x Verlag  |z lizenzpflichtig  |3 Volltext 
883 |8 1\p  |a cgwrk  |d 20241001  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
883 |8 2\p  |a cgwrk  |d 20241001  |q DE-101  |u https://d-nb.info/provenance/plan#cgwrk 
951 |a AR 
992 |a 20210512 
993 |a Article 
994 |a 2021 
998 |g 132405121  |a Opitz, Christiane  |m 132405121:Opitz, Christiane  |d 910000  |d 911100  |e 910000PO132405121  |e 911100PO132405121  |k 0/910000/  |k 1/910000/911100/  |p 46 
998 |g 1155118294  |a Teleman, Aurelio A.  |m 1155118294:Teleman, Aurelio A.  |d 140000  |e 140000PT1155118294  |k 0/140000/  |p 37 
998 |g 103034115X  |a Deimling, Andreas von  |m 103034115X:Deimling, Andreas von  |d 910000  |d 912000  |e 910000PD103034115X  |e 912000PD103034115X  |k 0/910000/  |k 1/910000/912000/  |p 11 
999 |a KXP-PPN1757716661  |e 3927641545 
BIB |a Y 
SER |a journal 
JSO |a {"person":[{"given":"Mirja Tamara","role":"aut","family":"Prentzell","display":"Prentzell, Mirja Tamara"},{"given":"Ulrike","role":"aut","display":"Rehbein, Ulrike","family":"Rehbein"},{"display":"Cadena Sandoval, Marti","family":"Cadena Sandoval","given":"Marti","role":"aut"},{"role":"aut","given":"Ann-Sofie","family":"De Meulemeester","display":"De Meulemeester, Ann-Sofie"},{"display":"Baumeister, Ralf","family":"Baumeister","given":"Ralf","role":"aut"},{"family":"Brohée","display":"Brohée, Laura","given":"Laura","role":"aut"},{"given":"Bianca","role":"aut","family":"Berdel","display":"Berdel, Bianca"},{"role":"aut","given":"Mathias","display":"Bockwoldt, Mathias","family":"Bockwoldt"},{"family":"Carroll","display":"Carroll, Bernadette","given":"Bernadette","role":"aut"},{"display":"Chowdhury, Suvagata Roy","family":"Chowdhury","role":"aut","given":"Suvagata Roy"},{"given":"Andreas von","role":"aut","display":"Deimling, Andreas von","family":"Deimling"},{"role":"aut","given":"Constantinos","display":"Demetriades, Constantinos","family":"Demetriades"},{"given":"Gianluca","role":"aut","display":"Figlia, Gianluca","family":"Figlia"},{"role":"aut","given":"Mariana Eca Guimaraes","display":"de Araujo, Mariana Eca Guimaraes","family":"de Araujo"},{"family":"Heberle","display":"Heberle, Alexander M.","role":"aut","given":"Alexander M."},{"display":"Heiland, Ines","family":"Heiland","given":"Ines","role":"aut"},{"display":"Holzwarth, Birgit","family":"Holzwarth","given":"Birgit","role":"aut"},{"given":"Lukas A.","role":"aut","display":"Huber, Lukas A.","family":"Huber"},{"given":"Jacek","role":"aut","display":"Jaworski, Jacek","family":"Jaworski"},{"family":"Kedra","display":"Kedra, Magdalena","role":"aut","given":"Magdalena"},{"given":"Katharina","role":"aut","family":"Kern","display":"Kern, Katharina"},{"role":"aut","given":"Andrii","display":"Kopach, Andrii","family":"Kopach"},{"display":"Korolchuk, Viktor I.","family":"Korolchuk","role":"aut","given":"Viktor I."},{"display":"van 't Land-Kuper, Ineke","family":"van 't Land-Kuper","role":"aut","given":"Ineke"},{"given":"Matylda","role":"aut","family":"Macias","display":"Macias, Matylda"},{"family":"Nellist","display":"Nellist, Mark","given":"Mark","role":"aut"},{"given":"Wilhelm","role":"aut","display":"Palm, Wilhelm","family":"Palm"},{"display":"Pusch, Stefan","family":"Pusch","given":"Stefan","role":"aut"},{"family":"Ramos Pittol","display":"Ramos Pittol, Jose Miguel","role":"aut","given":"Jose Miguel"},{"display":"Reil, Michèle","family":"Reil","given":"Michèle","role":"aut"},{"display":"Reintjes, Anja","family":"Reintjes","given":"Anja","role":"aut"},{"display":"Reuter, Friederike","family":"Reuter","role":"aut","given":"Friederike"},{"given":"Julian R.","role":"aut","display":"Sampson, Julian R.","family":"Sampson"},{"given":"Chloë","role":"aut","family":"Scheldeman","display":"Scheldeman, Chloë"},{"display":"Siekierska, Aleksandra","family":"Siekierska","role":"aut","given":"Aleksandra"},{"family":"Stefan","display":"Stefan, Eduard","given":"Eduard","role":"aut"},{"display":"Teleman, Aurelio A.","family":"Teleman","role":"aut","given":"Aurelio A."},{"role":"aut","given":"Christiane","family":"Opitz","display":"Opitz, Christiane"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 12.05.2021"],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"25 January 2021"}],"title":[{"title_sort":"G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling","title":"G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling"}],"recId":"1757716661","physDesc":[{"extent":"20 S."}],"name":{"displayForm":["Mirja Tamara Prentzell, Ulrike Rehbein, Marti Cadena Sandoval, Ann-Sofie De Meulemeester, Ralf Baumeister, Laura Brohée, Bianca Berdel, Mathias Bockwoldt, Bernadette Carroll, Suvagata Roy Chowdhury, Andreas von Deimling, Constantinos Demetriades, Gianluca Figlia, Mariana Eca Guimaraes de Araujo, Alexander M. Heberle, Ines Heiland, Birgit Holzwarth, Lukas A. Huber, Jacek Jaworski, Magdalena Kedra, Katharina Kern, Andrii Kopach, Viktor I. Korolchuk, Ineke van 't Land-Kuper, Matylda Macias, Mark Nellist, Wilhelm Palm, Stefan Pusch, Jose Miguel Ramos Pittol, Michèle Reil, Anja Reintjes, Friederike Reuter, Julian R. Sampson, Chloë Scheldeman, Aleksandra Siekierska, Eduard Stefan, Aurelio A. Teleman, Laura E. Thomas, Omar Torres-Quesada, Saskia Trump, Hannah D. West, Peter de Witte, Sandra Woltering, Teodor E. Yordanov, Justyna Zmorzynska, Christiane A. Opitz, Kathrin Thedieck"]},"id":{"eki":["1757716661"],"doi":["10.1016/j.cell.2020.12.024"]},"relHost":[{"id":{"zdb":["2001951-8"],"eki":["320416127"],"issn":["1097-4172"]},"pubHistory":["1.1974 -"],"recId":"320416127","physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"title":"Cell","title_sort":"Cell"}],"note":["Gesehen am 11.03.24"],"origin":[{"publisherPlace":"[Cambridge, Mass.] ; New York, NY","dateIssuedDisp":"1974-","dateIssuedKey":"1974","publisher":"Cell Press ; Elsevier"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"year":"2021","pages":"655-674","text":"184(2021,3), Seite 655-674, e1-e19, 47 Seiten","extent":"20","volume":"184","issue":"3"},"disp":"G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signalingCell"}]} 
SRT |a PRENTZELLMG3BPSTETHE2520 

Similar Items