Buchumschlag

Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin

Erythropoietin (EPO) and its receptor are expressed in the brain, and one of its roles appears to be neuroprotection. This study investigates whether chronic overexpression of EPO changes brain mRNA expression in the brains of transgenic mice. Therefore, cerebral mRNA expression was investigated in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Maurer, Martin H. (VerfasserIn) , Frietsch, Thomas (VerfasserIn) , Waschke, Klaus F. (VerfasserIn) , Kuschinsky, Wolfgang (VerfasserIn) , Gassmann, Max (VerfasserIn) , Schneider, Armin (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [2002]
In: Neuroscience letters
Year: 2002, Jahrgang: 327, Heft: 3, Pages: 181-184
ISSN:1872-7972
DOI:10.1016/S0304-3940(02)00425-1
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0304-3940(02)00425-1
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304394002004251
Volltext
Verfasserangaben:Martin H Maurer, Thomas Frietsch, Klaus F Waschke, Wolfgang Kuschinsky, Max Gassmann, Armin Schneider

MARC

LEADER 00000caa a2200000 c 4500
001 1757753311
003 DE-627
005 20220819204248.0
007 cr uuu---uuuuu
008 210512s2002 xx |||||o 00| ||eng c
024 7 |a 10.1016/S0304-3940(02)00425-1  |2 doi 
035 |a (DE-627)1757753311 
035 |a (DE-599)KXP1757753311 
035 |a (OCoLC)1341409014 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Maurer, Martin H.  |d 1971-  |e VerfasserIn  |0 (DE-588)121878112  |0 (DE-627)081593309  |0 (DE-576)182104672  |4 aut 
245 1 0 |a Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin  |c Martin H Maurer, Thomas Frietsch, Klaus F Waschke, Wolfgang Kuschinsky, Max Gassmann, Armin Schneider 
264 1 |c [2002] 
300 |b Illustrationen 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 12.05.2021 
520 |a Erythropoietin (EPO) and its receptor are expressed in the brain, and one of its roles appears to be neuroprotection. This study investigates whether chronic overexpression of EPO changes brain mRNA expression in the brains of transgenic mice. Therefore, cerebral mRNA expression was investigated in transgenic mice overexpressing EPO. Microarray analysis revealed an upregulation (2.8- to 3.6-fold) of N-acetylglucosamine-6-O-sulfotransferase (prolongation of the EPO effect), a translocase of the inner mitochondrial membrane (mitochondrial matrix import of nuclear encoded proteins), a mitochondrial ribosomal protein (mitochondrial protein translation), and a peroxisomal biogenesis factor (formation of peroxisomes). In conclusion, components of oxidative metabolism pathways were activated at the level of transcription which could be related to neuroprotective effects of EPO or could indicate compromised tissue. 
650 4 |a -Acetylglucosamine-6;sulfotransferase 
650 4 |a Adaptation 
650 4 |a cDNA microarrays 
650 4 |a Erythropoietin 
650 4 |a Mitochondrial 
650 4 |a Mouse 
650 4 |a Physiological 
650 4 |a RNA 
650 4 |a Transgenic 
700 1 |a Frietsch, Thomas  |d 1962-  |e VerfasserIn  |0 (DE-588)12171022X  |0 (DE-627)081483112  |0 (DE-576)292842716  |4 aut 
700 1 |a Waschke, Klaus F.  |d 1958-  |e VerfasserIn  |0 (DE-588)1106411064  |0 (DE-627)863132863  |0 (DE-576)175823391  |4 aut 
700 1 |a Kuschinsky, Wolfgang  |d 1944-  |e VerfasserIn  |0 (DE-588)1145453708  |0 (DE-627)1005597847  |0 (DE-576)161874711  |4 aut 
700 1 |a Gassmann, Max  |d 1960-  |e VerfasserIn  |0 (DE-588)1089237642  |0 (DE-627)853042829  |0 (DE-576)459801589  |4 aut 
700 1 |a Schneider, Armin  |d 1965-  |e VerfasserIn  |0 (DE-588)120356775  |0 (DE-627)696597012  |0 (DE-576)189089946  |4 aut 
773 0 8 |i Enthalten in  |t Neuroscience letters  |d Amsterdam [u.a.] : Elsevier Science, 1975  |g 327(2002), 3, Seite 181-184  |h Online-Ressource  |w (DE-627)306589699  |w (DE-600)1498535-4  |w (DE-576)081953119  |x 1872-7972  |7 nnas  |a Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin 
773 1 8 |g volume:327  |g year:2002  |g number:3  |g pages:181-184  |g extent:4  |a Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin 
856 4 0 |u https://doi.org/10.1016/S0304-3940(02)00425-1  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0304394002004251  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210512 
993 |a Article 
994 |a 2002 
998 |g 1145453708  |a Kuschinsky, Wolfgang  |m 1145453708:Kuschinsky, Wolfgang  |d 50000  |d 53200  |e 50000PK1145453708  |e 53200PK1145453708  |k 0/50000/  |k 1/50000/53200/  |p 4 
998 |g 1106411064  |a Waschke, Klaus F.  |m 1106411064:Waschke, Klaus F.  |d 60000  |d 61600  |e 60000PW1106411064  |e 61600PW1106411064  |k 0/60000/  |k 1/60000/61600/  |p 3 
998 |g 12171022X  |a Frietsch, Thomas  |m 12171022X:Frietsch, Thomas  |d 60000  |d 61600  |e 60000PF12171022X  |e 61600PF12171022X  |k 0/60000/  |k 1/60000/61600/  |p 2 
998 |g 121878112  |a Maurer, Martin H.  |m 121878112:Maurer, Martin H.  |d 50000  |d 53200  |e 50000PM121878112  |e 53200PM121878112  |k 0/50000/  |k 1/50000/53200/  |p 1  |x j 
999 |a KXP-PPN1757753311  |e 3927727121 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"title":[{"subtitle":"an international multidisciplinary journal devoted to the rapid publication of basic research in the neurosciences","title":"Neuroscience letters","title_sort":"Neuroscience letters"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"zdb":["1498535-4"],"eki":["306589699"],"issn":["1872-7972"]},"pubHistory":["1.1975 -"],"disp":"Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietinNeuroscience letters","origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1975","dateIssuedDisp":"1975-","publisher":"Elsevier Science"}],"part":{"pages":"181-184","issue":"3","extent":"4","volume":"327","text":"327(2002), 3, Seite 181-184","year":"2002"},"note":["Gesehen am 20.02.20","Ungezählte Beil.: Supplement"],"language":["eng"],"recId":"306589699"}],"title":[{"title_sort":"Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin","title":"Cerebral transcriptome analysis of transgenic mice overexpressing erythropoietin"}],"physDesc":[{"noteIll":"Illustrationen","extent":"4 S."}],"id":{"doi":["10.1016/S0304-3940(02)00425-1"],"eki":["1757753311"]},"person":[{"display":"Maurer, Martin H.","family":"Maurer","given":"Martin H.","role":"aut"},{"display":"Frietsch, Thomas","family":"Frietsch","given":"Thomas","role":"aut"},{"display":"Waschke, Klaus F.","family":"Waschke","given":"Klaus F.","role":"aut"},{"given":"Wolfgang","role":"aut","display":"Kuschinsky, Wolfgang","family":"Kuschinsky"},{"family":"Gassmann","display":"Gassmann, Max","role":"aut","given":"Max"},{"given":"Armin","role":"aut","display":"Schneider, Armin","family":"Schneider"}],"origin":[{"dateIssuedKey":"2002","dateIssuedDisp":"[2002]"}],"note":["Gesehen am 12.05.2021"],"language":["eng"],"recId":"1757753311","name":{"displayForm":["Martin H Maurer, Thomas Frietsch, Klaus F Waschke, Wolfgang Kuschinsky, Max Gassmann, Armin Schneider"]}} 
SRT |a MAURERMARTCEREBRALTR2002 

Ähnliche Einträge