Cover Image

Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators

In North America, tick-borne relapsing fever is caused by the species Borrelia hermsii, B. parkeri, and B. turicatae, which are transmitted to humans through the bite of the respective infected tick vectors. Here we describe the identification and functional characterization of a surface lipoprotein...

Full description

Saved in:
Bibliographic Details
Main Authors: Schott, Melanie (Author) , Grosskinsky, Sonja (Author) , Brenner, Christiane (Author) , Kraiczy, Peter (Author) , Wallich, Reinhard (Author)
Format: Article (Journal)
Language:English
Published: 15 March 2010
In: Infection and immunity
Year: 2010, Volume: 78, Issue: 5, Pages: 2199-2208
ISSN:1098-5522
DOI:10.1128/IAI.00089-10
Online Access:Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1128/IAI.00089-10
Verlag, Volltext: https://iai.asm.org/content/78/5/2199
Get full text
Author Notes:Melanie Schott, Sonja Grosskinsky, Christiane Brenner, Peter Kraiczy, and Reinhard Wallich

MARC

LEADER 00000caa a2200000 c 4500
001 1757905340
003 DE-627
005 20230428185606.0
007 cr uuu---uuuuu
008 210517s2010 xx |||||o 00| ||eng c
024 7 |a 10.1128/IAI.00089-10  |2 doi 
035 |a (DE-627)1757905340 
035 |a (DE-599)KXP1757905340 
035 |a (OCoLC)1341409096 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Schott, Melanie  |d 1978-  |e VerfasserIn  |0 (DE-588)140767436  |0 (DE-627)621598747  |0 (DE-576)320691926  |4 aut 
245 1 0 |a Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators  |c Melanie Schott, Sonja Grosskinsky, Christiane Brenner, Peter Kraiczy, and Reinhard Wallich 
264 1 |c 15 March 2010 
300 |a 10 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 17.05.2021 
520 |a In North America, tick-borne relapsing fever is caused by the species Borrelia hermsii, B. parkeri, and B. turicatae, which are transmitted to humans through the bite of the respective infected tick vectors. Here we describe the identification and functional characterization of a surface lipoprotein of B. parkeri, designated BpcA, that binds the human complement regulators factor H and factor H-related protein 1 and, simultaneously, the host protease plasminogen. In contrast, the homologous B. turicatae protein failed to bind human factor H and factor H-related protein 1 but retained its plasminogen binding capacity. Factor H bound to BpcA maintains its regulatory capacity to control C3b deposition and C3 convertase activity. Ectopic expression of BpcA in a serum-sensitive B. burgdorferi strain protects transformed cells from complement-mediated killing. Furthermore, bound plasminogen/plasmin endows B. parkeri and B. turicatae with the potential to degrade extracellular matrix components. These findings expand our understanding of the putative recent evolutionary separation of Borrelia parkeri and Borrelia turicatae, provide evidence that B. parkeri differs from B. turicatae in its ability to resist complement attack, and may help in understanding the pathological processes underlying tick-borne relapsing fever. 
650 4 |a Amino Acid Sequence 
650 4 |a Bacterial Proteins 
650 4 |a Blood Bactericidal Activity 
650 4 |a Blood Proteins 
650 4 |a Borrelia 
650 4 |a Complement Factor H 
650 4 |a DNA, Bacterial 
650 4 |a Humans 
650 4 |a Molecular Sequence Data 
650 4 |a North America 
650 4 |a Plasminogen 
650 4 |a Protein Binding 
650 4 |a Sequence Alignment 
650 4 |a Sequence Analysis, DNA 
700 1 |a Grosskinsky, Sonja  |e VerfasserIn  |0 (DE-588)141204125  |0 (DE-627)703910566  |0 (DE-576)32273374X  |4 aut 
700 1 |a Brenner, Christiane  |e VerfasserIn  |0 (DE-588)1161611304  |0 (DE-627)1024894479  |0 (DE-576)506757242  |4 aut 
700 1 |a Kraiczy, Peter  |e VerfasserIn  |0 (DE-588)1153855461  |0 (DE-627)1015413765  |0 (DE-576)500613168  |4 aut 
700 1 |a Wallich, Reinhard  |e VerfasserIn  |0 (DE-588)1059566710  |0 (DE-627)798640839  |0 (DE-576)163467781  |4 aut 
773 0 8 |i Enthalten in  |t Infection and immunity  |d Washington, DC : Soc., 1970  |g 78(2010), 5, Seite 2199-2208  |h Online-Ressource  |w (DE-627)300894694  |w (DE-600)1483247-1  |w (DE-576)095925554  |x 1098-5522  |7 nnas  |a Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators 
773 1 8 |g volume:78  |g year:2010  |g number:5  |g pages:2199-2208  |g extent:10  |a Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators 
856 4 0 |u https://dx.doi.org/10.1128/IAI.00089-10  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://iai.asm.org/content/78/5/2199  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20210517 
993 |a Article 
994 |a 2010 
998 |g 1059566710  |a Wallich, Reinhard  |m 1059566710:Wallich, Reinhard  |d 910000  |d 911600  |e 910000PW1059566710  |e 911600PW1059566710  |k 0/910000/  |k 1/910000/911600/  |p 5  |y j 
998 |g 1161611304  |a Brenner, Christiane  |m 1161611304:Brenner, Christiane  |d 910000  |d 911600  |e 910000PB1161611304  |e 911600PB1161611304  |k 0/910000/  |k 1/910000/911600/  |p 3 
998 |g 141204125  |a Grosskinsky, Sonja  |m 141204125:Grosskinsky, Sonja  |d 910000  |d 911600  |e 910000PG141204125  |e 911600PG141204125  |k 0/910000/  |k 1/910000/911600/  |p 2 
998 |g 140767436  |a Schott, Melanie  |m 140767436:Schott, Melanie  |d 910000  |d 911600  |e 910000PS140767436  |e 911600PS140767436  |k 0/910000/  |k 1/910000/911600/  |p 1  |x j 
999 |a KXP-PPN1757905340  |e 3928992724 
BIB |a Y 
SER |a journal 
JSO |a {"relHost":[{"name":{"displayForm":["publ. by the American Society for Microbiology"]},"id":{"zdb":["1483247-1"],"eki":["300894694"],"issn":["1098-5522"]},"origin":[{"publisherPlace":"Washington, DC","dateIssuedDisp":"1970-","publisher":"Soc.","dateIssuedKey":"1970"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Infection and immunity","title_sort":"Infection and immunity"}],"recId":"300894694","corporate":[{"display":"American Society for Microbiology","roleDisplay":"Herausgebendes Organ","role":"isb"}],"language":["eng"],"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 08.06.2021"],"disp":"Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulatorsInfection and immunity","type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"10","text":"78(2010), 5, Seite 2199-2208","volume":"78","issue":"5","pages":"2199-2208","year":"2010"},"pubHistory":["1.1970 -"]}],"physDesc":[{"extent":"10 S."}],"name":{"displayForm":["Melanie Schott, Sonja Grosskinsky, Christiane Brenner, Peter Kraiczy, and Reinhard Wallich"]},"id":{"doi":["10.1128/IAI.00089-10"],"eki":["1757905340"]},"origin":[{"dateIssuedDisp":"15 March 2010","dateIssuedKey":"2010"}],"recId":"1757905340","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 17.05.2021"],"person":[{"given":"Melanie","family":"Schott","role":"aut","display":"Schott, Melanie","roleDisplay":"VerfasserIn"},{"family":"Grosskinsky","given":"Sonja","display":"Grosskinsky, Sonja","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Brenner, Christiane","roleDisplay":"VerfasserIn","role":"aut","family":"Brenner","given":"Christiane"},{"display":"Kraiczy, Peter","roleDisplay":"VerfasserIn","role":"aut","family":"Kraiczy","given":"Peter"},{"family":"Wallich","given":"Reinhard","display":"Wallich, Reinhard","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title_sort":"Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators","title":"Molecular characterization of the interaction of Borrelia parkeri and Borrelia turicatae with human complement regulators"}]} 
SRT |a SCHOTTMELAMOLECULARC1520 

Similar Items