B cell-regulated immune responses in tumor models and cancer patients

The essential role played by T cells in anticancer immunity is widely accepted. The immunosuppressive functions of regulatory T cells are central for tumor progression and have been endowed with a robust predictive value. Increasing evidence indicates that also B cells have a crucial part in the reg...

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Hauptverfasser: Fremd, Carlo (VerfasserIn) , Schütz, Florian (VerfasserIn) , Sohn, Christof (VerfasserIn) , Beckhove, Philipp (VerfasserIn) , Domschke, Christoph (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 01 Jul 2013
In: OncoImmunology
Year: 2013, Jahrgang: 2, Heft: 7
ISSN:2162-402X
DOI:10.4161/onci.25443
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4161/onci.25443
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Verfasserangaben:Carlo Fremd, Florian Schuetz, Christof Sohn, Philipp Beckhove & Christoph Domschke

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520 |a The essential role played by T cells in anticancer immunity is widely accepted. The immunosuppressive functions of regulatory T cells are central for tumor progression and have been endowed with a robust predictive value. Increasing evidence indicates that also B cells have a crucial part in the regulation of T-cell responses against tumors. Although experiments reporting the production of natural antitumor antibodies and the induction of cytotoxic immune responses have revealed a tumor-protective function for B cells, other findings suggest that B cells may also exert tumor-promoting functions, resulting in a controversial picture. Here, we review recent evidence on the interactions between B and T cells in murine models and cancer patients and their implications for cancer immunology. 
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