Production of a recombinant bacterial lipoprotein in higher plant chloroplasts
Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human va...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2006
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| In: |
Nature biotechnology
Year: 2005, Volume: 24, Issue: 1, Pages: 76-77 |
| ISSN: | 1546-1696 |
| DOI: | 10.1038/nbt1170 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nbt1170 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nbt1170 
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| Author Notes: | Karin Glenz, Bernadette Bouchon, Thomas Stehle, Reinhard Wallich, Markus M. Simon & Heribert Warzecha |
| Summary: | Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants. |
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| Item Description: | Published online: 4 December 2005 Gesehen am 19.05.2021 |
| Physical Description: | Online Resource |
| ISSN: | 1546-1696 |
| DOI: | 10.1038/nbt1170 |