Production of a recombinant bacterial lipoprotein in higher plant chloroplasts
Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human va...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2006
|
| In: |
Nature biotechnology
Year: 2005, Volume: 24, Issue: 1, Pages: 76-77 |
| ISSN: | 1546-1696 |
| DOI: | 10.1038/nbt1170 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nbt1170 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nbt1170 
|
| Author Notes: | Karin Glenz, Bernadette Bouchon, Thomas Stehle, Reinhard Wallich, Markus M. Simon & Heribert Warzecha |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1758130709 | ||
| 003 | DE-627 | ||
| 005 | 20230427100719.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210519r20062005xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/nbt1170 |2 doi | |
| 035 | |a (DE-627)1758130709 | ||
| 035 | |a (DE-599)KXP1758130709 | ||
| 035 | |a (OCoLC)1341413511 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Glenz, Karin |d 1974- |e VerfasserIn |0 (DE-588)13089138X |0 (DE-627)507239903 |0 (DE-576)298399105 |4 aut | |
| 245 | 1 | 0 | |a Production of a recombinant bacterial lipoprotein in higher plant chloroplasts |c Karin Glenz, Bernadette Bouchon, Thomas Stehle, Reinhard Wallich, Markus M. Simon & Heribert Warzecha |
| 264 | 1 | |c 2006 | |
| 300 | |a 2 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online: 4 December 2005 | ||
| 500 | |a Gesehen am 19.05.2021 | ||
| 520 | |a Little is known about the potential of plastids to accomplish post-translational modifications of foreign proteins. In the present study we generated transplastomic tobacco plants that accumulate the outer surface lipoprotein A (OspA)-the basic constituent of the first generation monovalent human vaccine against Lyme disease. The recombinant OspA exhibits a lipid modification typical for bacteria and induced protective antibodies in mice, demonstrating that functionally active bacterial lipoproteins can be processed in plants. | ||
| 534 | |c 2005 | ||
| 650 | 4 | |a Antigens, Surface | |
| 650 | 4 | |a Bacterial Outer Membrane Proteins | |
| 650 | 4 | |a Bacterial Vaccines | |
| 650 | 4 | |a Base Sequence | |
| 650 | 4 | |a Chloroplasts | |
| 650 | 4 | |a Cloning, Molecular | |
| 650 | 4 | |a Lipoproteins | |
| 650 | 4 | |a Molecular Sequence Data | |
| 650 | 4 | |a Plants, Genetically Modified | |
| 650 | 4 | |a Protein Engineering | |
| 650 | 4 | |a Recombinant Proteins | |
| 650 | 4 | |a Tobacco | |
| 650 | 4 | |a Transfection | |
| 700 | 1 | |a Bouchon, Bernadette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stehle, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wallich, Reinhard |e VerfasserIn |0 (DE-588)1059566710 |0 (DE-627)798640839 |0 (DE-576)163467781 |4 aut | |
| 700 | 1 | |a Simon, Markus M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Warzecha, Heribert |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature biotechnology |d New York, NY : Springer Nature, 1996 |g 24(2006), 1, Seite 76-77 |h Online-Ressource |w (DE-627)30339370X |w (DE-600)1494943-X |w (DE-576)080887171 |x 1546-1696 |7 nnas |a Production of a recombinant bacterial lipoprotein in higher plant chloroplasts |
| 773 | 1 | 8 | |g volume:24 |g year:2006 |g number:1 |g pages:76-77 |g extent:2 |a Production of a recombinant bacterial lipoprotein in higher plant chloroplasts |
| 856 | 4 | 0 | |u https://doi.org/10.1038/nbt1170 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/nbt1170 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210519 | ||
| 993 | |a Article | ||
| 994 | |a 2006 | ||
| 998 | |g 1059566710 |a Wallich, Reinhard |m 1059566710:Wallich, Reinhard |d 910000 |d 911600 |e 910000PW1059566710 |e 911600PW1059566710 |k 0/910000/ |k 1/910000/911600/ |p 4 | ||
| 999 | |a KXP-PPN1758130709 |e 3929557096 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Production of a recombinant bacterial lipoprotein in higher plant chloroplasts","title_sort":"Production of a recombinant bacterial lipoprotein in higher plant chloroplasts"}],"person":[{"family":"Glenz","given":"Karin","roleDisplay":"VerfasserIn","display":"Glenz, Karin","role":"aut"},{"display":"Bouchon, Bernadette","roleDisplay":"VerfasserIn","role":"aut","family":"Bouchon","given":"Bernadette"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Stehle, Thomas","given":"Thomas","family":"Stehle"},{"given":"Reinhard","family":"Wallich","role":"aut","roleDisplay":"VerfasserIn","display":"Wallich, Reinhard"},{"given":"Markus M.","family":"Simon","role":"aut","display":"Simon, Markus M.","roleDisplay":"VerfasserIn"},{"family":"Warzecha","given":"Heribert","display":"Warzecha, Heribert","roleDisplay":"VerfasserIn","role":"aut"}],"recId":"1758130709","language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Published online: 4 December 2005","Gesehen am 19.05.2021"],"id":{"eki":["1758130709"],"doi":["10.1038/nbt1170"]},"origin":[{"dateIssuedKey":"2006","dateIssuedDisp":"2006"}],"name":{"displayForm":["Karin Glenz, Bernadette Bouchon, Thomas Stehle, Reinhard Wallich, Markus M. Simon & Heribert Warzecha"]},"relHost":[{"id":{"zdb":["1494943-X"],"eki":["30339370X"],"issn":["1546-1696"]},"origin":[{"publisherPlace":"New York, NY ; New York, NY","publisher":"Springer Nature ; Nature America","dateIssuedDisp":"[1996]-"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Nature biotechnology","subtitle":"the science and business of biotechnology","title":"Nature biotechnology"}],"part":{"text":"24(2006), 1, Seite 76-77","volume":"24","extent":"2","year":"2006","pages":"76-77","issue":"1"},"pubHistory":["Volume 14, issue 3 (March 1996)-"],"recId":"30339370X","language":["eng"],"note":["Gesehen am 18.07.2023"],"disp":"Production of a recombinant bacterial lipoprotein in higher plant chloroplastsNature biotechnology","type":{"media":"Online-Ressource","bibl":"periodical"}}],"physDesc":[{"extent":"2 S."}]} | ||
| SRT | |a GLENZKARINPRODUCTION2006 | ||