Drug interactions in primary care: Impact of a new algorithm on risk determination
Background If managed adequately, many drug interactions do not result in clinical manifestations. Earlier studies may have overestimated the risk arising from drug interactions because they usually reported interaction frequencies and the severity of potential outcomes irrespective of their managea...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 July 2004
|
| In: |
Clinical pharmacology & therapeutics
Year: 2004, Jahrgang: 76, Heft: 1, Pages: 85-96 |
| ISSN: | 1532-6535 |
| DOI: | https://doi.org/10.1016/j.clpt.2004.02.009 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/https://doi.org/10.1016/j.clpt.2004.02.009 Verlag, lizenzpflichtig, Volltext: https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/j.clpt.2004.02.009 
|
| Verfasserangaben: | Verena Bergk, Christiane Gasse, Dietrich Rothenbacher, Michael Loew, Hermann Brenner, Walter E. Haefeli |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1758153016 | ||
| 003 | DE-627 | ||
| 005 | 20230427100724.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210519s2004 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.clpt.2004.02.009 |2 doi | |
| 035 | |a (DE-627)1758153016 | ||
| 035 | |a (DE-599)KXP1758153016 | ||
| 035 | |a (OCoLC)1341413499 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bergk, Verena |d 1975- |e VerfasserIn |0 (DE-588)130040401 |0 (DE-627)488065216 |0 (DE-576)297964577 |4 aut | |
| 245 | 1 | 0 | |a Drug interactions in primary care |b Impact of a new algorithm on risk determination |c Verena Bergk, Christiane Gasse, Dietrich Rothenbacher, Michael Loew, Hermann Brenner, Walter E. Haefeli |
| 264 | 1 | |c 01 July 2004 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 19.05.2021 | ||
| 520 | |a Background If managed adequately, many drug interactions do not result in clinical manifestations. Earlier studies may have overestimated the risk arising from drug interactions because they usually reported interaction frequencies and the severity of potential outcomes irrespective of their manageability. Objective Our objective was to estimate the risk associated with drug interactions in a large population when not only the severity of possible clinical events but also measures of their prevention (manageability, modulating factors) are considered. Methods We evaluated all drug pairs concurrently prescribed to 9481 adults aged 50 to 75 years who participated in a health-screening examination. Drug interactions were evaluated by use of an algorithm with 4 decision layers (severity, manageability, risk/benefit assessment, and patient-related risk factors), and this risk evaluation was compared with the conventional evaluation solely on the basis of severity. Results More than 52% of the patients received combination therapy. Interaction information was available in a standard source (DRUGDEX; Thomson MICROMEDEX, Greenwood Village, Colo) for only 1029 of all 13,672 individual prescribed drug pairs. Of the drug pairs, 881 (6.4%) were identified as interacting. Of these 881 interactions, 132 (15.0%) were of major severity but 101 of 132 (76.5%) were considered manageable. Only 31 (23.5%) of 132 major interactions (ie, 31/881 [3.5% of all interacting pairs]) offered no management options and should thus be avoided. Conclusion For many commonly prescribed drug pairs, explicit drug interaction information is currently not available in DRUGDEX. For major interactions with published evidence, the overwhelming majority were manageable, and therefore risk estimates only based on the severity of potential outcomes will grossly overestimate the risk associated with such combinations. Clinical Pharmacology & Therapeutics (2004) 76, 85-96; doi: 10.1016/j.clpt.2004.02.009 | ||
| 700 | 1 | |a Gasse, Christiane |d 1969- |e VerfasserIn |0 (DE-588)122686691 |0 (DE-627)706000994 |0 (DE-576)293380759 |4 aut | |
| 700 | 1 | |a Rothenbacher, Dietrich |e VerfasserIn |0 (DE-588)1022161520 |0 (DE-627)716931451 |0 (DE-576)167264540 |4 aut | |
| 700 | 1 | |a Loew, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brenner, Hermann |e VerfasserIn |0 (DE-588)1020516445 |0 (DE-627)691247005 |0 (DE-576)360642136 |4 aut | |
| 700 | 1 | |a Haefeli, Walter E. |d 1958- |e VerfasserIn |0 (DE-588)124572359 |0 (DE-627)656806141 |0 (DE-576)340514221 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical pharmacology & therapeutics |d Hoboken, NJ : Wiley-Blackwell, 1960 |g 76(2004), 1, Seite 85-96 |h Online-Ressource |w (DE-627)325793247 |w (DE-600)2040184-X |w (DE-576)094531668 |x 1532-6535 |7 nnas |a Drug interactions in primary care Impact of a new algorithm on risk determination |
| 773 | 1 | 8 | |g volume:76 |g year:2004 |g number:1 |g pages:85-96 |g extent:12 |a Drug interactions in primary care Impact of a new algorithm on risk determination |
| 776 | 0 | 8 | |i Erscheint auch als |n Druck-Ausgabe |a Bergk, Verena, 1975 - |t Drug interactions in primary care |d 2004 |w (DE-627)1632714345 |w (DE-576)391835513 |
| 856 | 4 | 0 | |u https://doi.org/https://doi.org/10.1016/j.clpt.2004.02.009 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://ascpt.onlinelibrary.wiley.com/doi/abs/10.1016/j.clpt.2004.02.009 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210519 | ||
| 993 | |a Article | ||
| 994 | |a 2004 | ||
| 998 | |g 124572359 |a Haefeli, Walter E. |m 124572359:Haefeli, Walter E. |d 910000 |d 910100 |e 910000PH124572359 |e 910100PH124572359 |k 0/910000/ |k 1/910000/910100/ |p 6 |y j | ||
| 998 | |g 1020516445 |a Brenner, Hermann |m 1020516445:Brenner, Hermann |d 850000 |d 851600 |d 50000 |e 850000PB1020516445 |e 851600PB1020516445 |e 50000PB1020516445 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 5 | ||
| 998 | |g 1022161520 |a Rothenbacher, Dietrich |m 1022161520:Rothenbacher, Dietrich |d 850000 |d 851600 |d 50000 |e 850000PR1022161520 |e 851600PR1022161520 |e 50000PR1022161520 |k 0/850000/ |k 1/850000/851600/ |k 0/50000/ |p 3 | ||
| 998 | |g 130040401 |a Bergk, Verena Annemarie |m 130040401:Bergk, Verena Annemarie |d 50000 |e 50000PB130040401 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1758153016 |e 3929611309 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1758153016","note":["Gesehen am 19.05.2021"],"name":{"displayForm":["Verena Bergk, Christiane Gasse, Dietrich Rothenbacher, Michael Loew, Hermann Brenner, Walter E. Haefeli"]},"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["2040184-X"],"issn":["1532-6535"],"eki":["325793247"],"doi":["10.1002/(ISSN)1532-6535"]},"language":["eng"],"corporate":[{"role":"isb","display":"American Society for Clinical Pharmacology and Therapeutics"},{"role":"isb","display":"American Society for Pharmacology and Experimental Therapeutics"}],"part":{"volume":"76","text":"76(2004), 1, Seite 85-96","pages":"85-96","extent":"12","year":"2004","issue":"1"},"title":[{"subtitle":"CPT ; official publication of the American Society for Clinical Pharmacology and Therapeutics and the American Society for Pharmacology and Experimental Therapeutics","title":"Clinical pharmacology & therapeutics","title_sort":"Clinical pharmacology & therapeutics"}],"titleAlt":[{"title":"CPT"},{"title":"Clinical pharmacology and therapeutics"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"Wiley-Blackwell ; Mosby ; Nature Publ. Group","dateIssuedKey":"1960","publisherPlace":"Hoboken, NJ ; St. Louis, Mo. ; Basingstoke","dateIssuedDisp":"1960-"}],"pubHistory":["1.1960 -"],"note":["Gesehen am 18.02.2016"],"recId":"325793247","disp":"Drug interactions in primary care Impact of a new algorithm on risk determinationClinical pharmacology & therapeutics"}],"person":[{"role":"aut","given":"Verena","family":"Bergk","display":"Bergk, Verena"},{"role":"aut","given":"Christiane","family":"Gasse","display":"Gasse, Christiane"},{"role":"aut","given":"Dietrich","display":"Rothenbacher, Dietrich","family":"Rothenbacher"},{"given":"Michael","display":"Loew, Michael","family":"Loew","role":"aut"},{"role":"aut","given":"Hermann","family":"Brenner","display":"Brenner, Hermann"},{"display":"Haefeli, Walter E.","family":"Haefeli","given":"Walter E.","role":"aut"}],"physDesc":[{"extent":"12 S."}],"title":[{"title_sort":"Drug interactions in primary care","subtitle":"Impact of a new algorithm on risk determination","title":"Drug interactions in primary care"}],"id":{"doi":["10.1016/j.clpt.2004.02.009"],"eki":["1758153016"]},"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"origin":[{"dateIssuedKey":"2004","dateIssuedDisp":"01 July 2004"}]} | ||
| SRT | |a BERGKVERENDRUGINTERA0120 | ||