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A primaquine-chloroquine hybrid with dual activity against Plasmodium liver and blood stages

We present a new class of hybrid molecules consisting of the established antiplasmodial drugs primaquine and chloroquine. No drug is known to date that acts comparably against all stages of Plasmodium in its life cycle. Starting from available precursors, we designed and synthesized a new-generation...

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Main Authors: Loedige, Melanie (Author) , Lewis, Matthew (Author) , Paulsen, Eleonora S. (Author) , Esch, Harald L. (Author) , Pradel, Gabriele (Author) , Lehmann, Leane (Author) , Brun, Reto (Author) , Bringmann, Gerhard (Author) , Müller, Ann-Kristin (Author)
Format: Article (Journal)
Language:English
Published: 5 August 2013
In: International journal of medical microbiology
Year: 2013, Volume: 303, Issue: 8, Pages: 539-547
ISSN:1618-0607
DOI:10.1016/j.ijmm.2013.07.005
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijmm.2013.07.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S143842211300101X
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Author Notes:Melanie Lödige, Matthew D. Lewis, Eleonora S. Paulsen, Harald L. Esch, Gabriele Pradel, Leane Lehmann, Reto Brun, Gerhard Bringmann, Ann-Kristin Mueller

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