Vitamin C und Thiamin im Septischen Schock: eine retrospektive Vorher-Nachher-Studie an chirurgischen Patienten = Vitamin C and thiamine in septic shock : a retrospective before-and-after study on surgical patients
Background: The administration of vitamin C and thiamine in septic shock is an innovative therapeutic approach. This study investigated the effect of vitamin C and thiamine in a surgical patient cohort with a predominantly abdominal focus. Methods: Clinical care data of septic shock patients between...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Deutsch |
| Veröffentlicht: |
Februar 2021
|
| In: |
Anästhesiologie & Intensivmedizin
Year: 2021, Jahrgang: 62, Pages: 63-69 |
| ISSN: | 1439-0256 |
| DOI: | 10.19224/ai2021.063 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.19224/ai2021.063 Verlag, lizenzpflichtig, Volltext: https://www.ai-online.info/archiv/2021/02-2021/vitamin-c-und-thiamin-im-septischen-schock-eine-retrospektive-vorher-nachher-studie-an-chirurgischen-patienten.html 
|
| Verfasserangaben: | M. Dietrich, M. Martens, M. von der Forst, T. Bruckner, F. Uhle, M. Fiedler, S. Weiterer, T. Hackert, T. Brenner, M.A. Weigand |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1758213582 | ||
| 003 | DE-627 | ||
| 005 | 20230427100737.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210520s2021 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.19224/ai2021.063 |2 doi | |
| 035 | |a (DE-627)1758213582 | ||
| 035 | |a (DE-599)KXP1758213582 | ||
| 035 | |a (OCoLC)1341413431 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a ger | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Dietrich, Maximilian |d 1991- |e VerfasserIn |0 (DE-588)1172010889 |0 (DE-627)1040838707 |0 (DE-576)513949259 |4 aut | |
| 245 | 1 | 0 | |a Vitamin C und Thiamin im Septischen Schock |b eine retrospektive Vorher-Nachher-Studie an chirurgischen Patienten = Vitamin C and thiamine in septic shock : a retrospective before-and-after study on surgical patients |c M. Dietrich, M. Martens, M. von der Forst, T. Bruckner, F. Uhle, M. Fiedler, S. Weiterer, T. Hackert, T. Brenner, M.A. Weigand |
| 246 | 3 | 1 | |a Vitamin C and thiamine in septic shock |b a retrospective before-and-after study on surgical patients |
| 264 | 1 | |c Februar 2021 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.05.2021 | ||
| 520 | |a Background: The administration of vitamin C and thiamine in septic shock is an innovative therapeutic approach. This study investigated the effect of vitamin C and thiamine in a surgical patient cohort with a predominantly abdominal focus. Methods: Clinical care data of septic shock patients between November 2017 and December 2019 were analysed retrospectively. All patients received sepsis therapy including hydrocortisone. The adjunctive therapy with 1.5 g vitamin C every 6 hours and 200 mg thiamine every 12 hours over 4 days was introduced in January 2019. The control group consisted of patients treated before the introduction of adjunctive therapy. Primary endpoints were in-hospital and 28-day mortality. Secondary endpoints were the duration of the patients' intensive care and invasive ventilation as well as SOFA score, C-reactive protein (CRP), serum creatinine, procalcitonin and leukocytes. Results: Both groups included 61 patients. The abdomen was the most frequent infection site (80 %). 22 patients (36.1 %) of the vitamin group and 27 patients (44.3 %) of the control group had died after 28 days (p = 0.356). In-hospital mortality of the vitamin group was 41.0 %, compared with 54.0% in the control group (p = 0.147). The duration of mechanical ventilation (6 days vs. 10 days, p = 0.029) was significantly shorter in the vitamin group. There were no significant differences in creatinine or the need for renal replacement therapy. Conclusion: High-dose vitamin C and thiamine in septic shock did not significantly reduce 28-day or in-hospital mortality in this analysis. However, a shorter duration of mechanical ventilation without an increased rate of renal complications was observed. | ||
| 650 | 4 | |a Intensive Care | |
| 650 | 4 | |a Sepsis | |
| 650 | 4 | |a Shock | |
| 650 | 4 | |a Thiamine | |
| 650 | 4 | |a Vitamin C | |
| 700 | 1 | |a Märtens, Malte |e VerfasserIn |0 (DE-588)1081735538 |0 (DE-627)846567350 |0 (DE-576)454736738 |4 aut | |
| 700 | 1 | |a Forst, Maik von der |e VerfasserIn |0 (DE-588)1233794604 |0 (DE-627)1758215569 |4 aut | |
| 700 | 1 | |a Bruckner, Thomas |d 1956- |e VerfasserIn |0 (DE-588)136046215 |0 (DE-627)574429298 |0 (DE-576)300798768 |4 aut | |
| 700 | 1 | |a Uhle, Florian |e VerfasserIn |0 (DE-588)106860560X |0 (DE-627)820511730 |0 (DE-576)427922534 |4 aut | |
| 700 | 1 | |a Fiedler-Kalenka, Mascha |d 1979- |e VerfasserIn |0 (DE-588)1018788603 |0 (DE-627)683425951 |0 (DE-576)356370283 |4 aut | |
| 700 | 1 | |a Weiterer, Sebastian |e VerfasserIn |0 (DE-588)142194107 |0 (DE-627)634428225 |0 (DE-576)329420135 |4 aut | |
| 700 | 1 | |a Hackert, Thilo |d 1971- |e VerfasserIn |0 (DE-588)122158512 |0 (DE-627)70579346X |0 (DE-576)182659208 |4 aut | |
| 700 | 1 | |a Brenner, Thorsten |d 1978- |e VerfasserIn |0 (DE-588)130125709 |0 (DE-627)491713363 |0 (DE-576)189360607 |4 aut | |
| 700 | 1 | |a Weigand, Markus A. |d 1967- |e VerfasserIn |0 (DE-588)1064970435 |0 (DE-627)815375239 |0 (DE-576)424658666 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anästhesiologie & Intensivmedizin |d Ebelsbach : Aktiv Dr. und Verl., 1978 |g 62(2021) vom: Feb., Seite 63-69 |h Online-Ressource |w (DE-627)503718459 |w (DE-600)2211357-5 |w (DE-576)25261450X |x 1439-0256 |7 nnas |a Vitamin C und Thiamin im Septischen Schock eine retrospektive Vorher-Nachher-Studie an chirurgischen Patienten = Vitamin C and thiamine in septic shock : a retrospective before-and-after study on surgical patients |
| 773 | 1 | 8 | |g volume:62 |g year:2021 |g month:02 |g pages:63-69 |g extent:7 |a Vitamin C und Thiamin im Septischen Schock eine retrospektive Vorher-Nachher-Studie an chirurgischen Patienten = Vitamin C and thiamine in septic shock : a retrospective before-and-after study on surgical patients |
| 856 | 4 | 0 | |u https://doi.org/10.19224/ai2021.063 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ai-online.info/archiv/2021/02-2021/vitamin-c-und-thiamin-im-septischen-schock-eine-retrospektive-vorher-nachher-studie-an-chirurgischen-patienten.html |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210520 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1064970435 |a Weigand, Markus A. |m 1064970435:Weigand, Markus A. |d 910000 |d 910300 |e 910000PW1064970435 |e 910300PW1064970435 |k 0/910000/ |k 1/910000/910300/ |p 10 |y j | ||
| 998 | |g 130125709 |a Brenner, Thorsten |m 130125709:Brenner, Thorsten |d 50000 |e 50000PB130125709 |k 0/50000/ |p 9 | ||
| 998 | |g 122158512 |a Hackert, Thilo |m 122158512:Hackert, Thilo |d 910000 |d 910200 |d 50000 |e 910000PH122158512 |e 910200PH122158512 |e 50000PH122158512 |k 0/910000/ |k 1/910000/910200/ |k 0/50000/ |p 8 | ||
| 998 | |g 1018788603 |a Fiedler-Kalenka, Mascha |m 1018788603:Fiedler-Kalenka, Mascha |d 910000 |d 910300 |e 910000PF1018788603 |e 910300PF1018788603 |k 0/910000/ |k 1/910000/910300/ |p 6 | ||
| 998 | |g 106860560X |a Uhle, Florian |m 106860560X:Uhle, Florian |d 910000 |d 910300 |e 910000PU106860560X |e 910300PU106860560X |k 0/910000/ |k 1/910000/910300/ |p 5 | ||
| 998 | |g 136046215 |a Bruckner, Thomas |m 136046215:Bruckner, Thomas |d 910000 |d 999701 |e 910000PB136046215 |e 999701PB136046215 |k 0/910000/ |k 1/910000/999701/ |p 4 | ||
| 998 | |g 1233794604 |a Forst, Maik von der |m 1233794604:Forst, Maik von der |d 910000 |d 910300 |e 910000PF1233794604 |e 910300PF1233794604 |k 0/910000/ |k 1/910000/910300/ |p 3 | ||
| 998 | |g 1081735538 |a Märtens, Malte |m 1081735538:Märtens, Malte |d 910000 |d 910300 |e 910000PM1081735538 |e 910300PM1081735538 |k 0/910000/ |k 1/910000/910300/ |p 2 | ||
| 998 | |g 1172010889 |a Dietrich, Maximilian |m 1172010889:Dietrich, Maximilian |d 910000 |d 910300 |e 910000PD1172010889 |e 910300PD1172010889 |k 0/910000/ |k 1/910000/910300/ |p 1 |x j | ||
| 999 | |a KXP-PPN1758213582 |e 3929798190 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1758213582"],"doi":["10.19224/ai2021.063"]},"physDesc":[{"extent":"7 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1439-0256"],"zdb":["2211357-5"],"eki":["503718459"]},"part":{"year":"2021","extent":"7","pages":"63-69","volume":"62","text":"62(2021) vom: Feb., Seite 63-69"},"note":["Volltext auch als Teil einer Datenbank verfügbar","Gesehen am 02.09.2021"],"origin":[{"publisherPlace":"Ebelsbach","dateIssuedKey":"1978","dateIssuedDisp":"1978-","publisher":"Aktiv Dr. und Verl."}],"name":{"displayForm":["Hrsg.: Deutsche Gesellschaft für Anästhesiologie und Intensivmedizin (DGAI)"]},"title":[{"subtitle":"offizielles Organ der Deutschen Gesellschaft für Anästhesiologie und Intensivmedizin, des Berufsverbandes Deutscher Anästhesisten und der Deutschen Akademie für Anästhesiologische Fortbildung","title_sort":"Anästhesiologie & Intensivmedizin","title":"Anästhesiologie & Intensivmedizin"}],"pubHistory":["19.1978,9 -"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"503718459","disp":"Vitamin C und Thiamin im Septischen Schock eine retrospektive Vorher-Nachher-Studie an chirurgischen Patienten = Vitamin C and thiamine in septic shock : a retrospective before-and-after study on surgical patientsAnästhesiologie & Intensivmedizin","language":["ger"],"titleAlt":[{"title":"Anästhesiologie und Intensivmedizin"},{"title":"A & I"}]}],"note":["Gesehen am 20.05.2021"],"recId":"1758213582","titleTranslated":[{"translated":"Vitamin C and thiamine in septic shock"}],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"Februar 2021"}],"name":{"displayForm":["M. Dietrich, M. Martens, M. von der Forst, T. Bruckner, F. Uhle, M. Fiedler, S. Weiterer, T. Hackert, T. Brenner, M.A. Weigand"]},"person":[{"family":"Dietrich","display":"Dietrich, Maximilian","given":"Maximilian","role":"aut"},{"role":"aut","display":"Märtens, Malte","given":"Malte","family":"Märtens"},{"role":"aut","display":"Forst, Maik von der","given":"Maik von der","family":"Forst"},{"family":"Bruckner","given":"Thomas","display":"Bruckner, Thomas","role":"aut"},{"role":"aut","family":"Uhle","given":"Florian","display":"Uhle, Florian"},{"role":"aut","given":"Mascha","display":"Fiedler-Kalenka, Mascha","family":"Fiedler-Kalenka"},{"role":"aut","family":"Weiterer","display":"Weiterer, Sebastian","given":"Sebastian"},{"role":"aut","family":"Hackert","display":"Hackert, Thilo","given":"Thilo"},{"role":"aut","given":"Thorsten","display":"Brenner, Thorsten","family":"Brenner"},{"family":"Weigand","display":"Weigand, Markus A.","given":"Markus A.","role":"aut"}],"language":["ger"],"title":[{"title":"Vitamin C und Thiamin im Septischen Schock","subtitle":"eine retrospektive Vorher-Nachher-Studie an chirurgischen Patienten = Vitamin C and thiamine in septic shock : a retrospective before-and-after study on surgical patients","title_sort":"Vitamin C und Thiamin im Septischen Schock"}]} | ||
| SRT | |a DIETRICHMAVITAMINCUN2021 | ||