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Fine-scale mapping of the FGFR2 breast cancer risk locus: putative functional variants differentially bind FOXA1 and E2F1

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The 10q26 locus in the second intron of FGFR2 is the locus most strongly associated with estrogen-receptor-positive breast cancer in genome-wide association studies. We conducted fine-scale mapping in case-control studies genotyped with a custom chip (iCOGS), comprising 41 studies (n = 89,050) of Eu...

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Main Authors: Meyer, Kerstin B. (Author) , Marmé, Frederik (Author) , Schneeweiss, Andreas (Author) , Sohn, Christof (Author) , Burwinkel, Barbara (Author) , Brenner, Hermann (Author) , Müller, Heiko (Author) , Arndt, Volker (Author) , Chang-Claude, Jenny (Author) , Rudolph, Anja (Author) , Seibold, Petra Beate (Author) , Hamann, Ute (Author)
Format: Article (Journal)
Language:English
Published: 27 November 2013
In: The American journal of human genetics
Year: 2013, Volume: 93, Issue: 6, Pages: 1046-1060
ISSN:1537-6605
DOI:10.1016/j.ajhg.2013.10.026
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ajhg.2013.10.026
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0002929713004837
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Author Notes:Kerstin B. Meyer, Federick Marme, Andreas Schneeweiss, Christof Sohn, Barbara Burwinkel, Hermann Brenner, Heiko Müller, Volker Arndt, Jenny Chang-Claude, Anja Rudolph, Petra Seibold, Ute Hamann [und weitere Verfasser]
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Cancer risks associated with BRCA1 and BRCA2 pathogenic variants by Li, Shuai (Author) , Hamann, Ute (Author) , Sutter, Christian (Author) ,


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A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers by Coignard, Juliette (Author) , Arndt, Volker (Author) , Brenner, Hermann (Author) , Burwinkel, Barbara (Author) , Chang-Claude, Jenny (Author) , Hamann, Ute (Author) , Kaaks, Rudolf (Author) , Kapoor, Pooja Middha (Author) ,


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Germline BRCA1/2 mutations and severe haematological toxicities in patients with breast cancer treated with neoadjuvant chemotherapy by Furlanetto, Jenny (Author) , Möbus, Volker (Author) , Schneeweiss, Andreas (Author) , Rhiem, Kerstin (Author) , Tesch, Hans (Author) , Blohmer, Jens-Uwe (Author) , Lübbe, Kristina (Author) , Untch, Michael (Author) , Salat, Christoph (Author) , Huober, Jens (Author) , Klare, Peter (Author) , Schmutzler, Rita (Author) , Couch, Fergus J. (Author) , Lederer, Bianca (Author) , Gerber, Bernd (Author) , Zahm, Dirk-Michael (Author) , Bauerfeind, Ingo (Author) , Nekljudova, Valentina (Author) , Hanusch, Claus (Author) , Jackisch, Christian (Author) , Link, Theresa (Author) , Hahnen, Eric (Author) , Loibl, Sibylle (Author) , Fasching, Peter A. (Author) ,


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Male breast cancer in BRCA1 and BRCA2 mutation carriers: pathology data from the Consortium of Investigators of Modifiers of BRCA1/2 by Silvestri, Valentina (Author) , Sutter, Christian (Author) , Hamann, Ute (Author) ,


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