Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolism
Background - Venous thromboembolism (VTE) constitute a major global burden of disease. Current international guidelines recommend treatment with anticoagulant therapy after VTE for a duration of at least 3 months. Since anticoagulation also imposes an increased risk for bleeding events, the individu...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2021
|
| In: |
International journal of cardiology
Year: 2020, Jahrgang: 329, Pages: 179-184 |
| ISSN: | 1874-1754 |
| DOI: | 10.1016/j.ijcard.2020.11.075 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijcard.2020.11.075 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167527320342467 
|
| Verfasserangaben: | Karsten Keller, Thomas Münzel, Lukas Hobohm, Mir A. Ostad |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1758310464 | ||
| 003 | DE-627 | ||
| 005 | 20240413193401.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210521r20212020xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijcard.2020.11.075 |2 doi | |
| 035 | |a (DE-627)1758310464 | ||
| 035 | |a (DE-599)KXP1758310464 | ||
| 035 | |a (OCoLC)1341413715 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Keller, Karsten |d 1974- |e VerfasserIn |0 (DE-588)133143589 |0 (DE-627)537504206 |0 (DE-576)299652041 |4 aut | |
| 245 | 1 | 0 | |a Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolism |c Karsten Keller, Thomas Münzel, Lukas Hobohm, Mir A. Ostad |
| 264 | 1 | |c 2021 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 8 December 2020 | ||
| 500 | |a Gesehen am 21.05.2021 | ||
| 520 | |a Background - Venous thromboembolism (VTE) constitute a major global burden of disease. Current international guidelines recommend treatment with anticoagulant therapy after VTE for a duration of at least 3 months. Since anticoagulation also imposes an increased risk for bleeding events, the individual risk has to be evaluated to determine adequate treatment plans. - Methods - The nationwide German inpatient sample of the years 2005-2017 was used for this analysis. Hospitalized VTE patients were stratified according to Kuijer risk class and the performance of the Kuijer score was evaluated to predict adverse in-hospital events. - Results - Overall, 1,204,895 VTE patients were treated between 2005 and 2017 in Germany and were included in the present study (839,143 patients had deep venous thrombosis and/or thrombophlebitis and 669,881 patients pulmonary embolism). According to Kuijer risk class stratification, in total, 176,723 (14.7%) of the hospitalized VTE patients were classified as low risk, 914,964 (75.9%) as intermediate risk and 113,208 (9.4%) as high risk. A higher Kuijer risk class was predictive for in-hospital death (odds ratio [OR] 1.99 [95% confidence interval (CI) 1.96-2.02], P < 0.001), major adverse cardiovascular and cerebrovascular events (MACCE, OR 1.90 [95%CI 1.87-1.93], P < 0.001), intracerebral bleeding (OR 1.28 [95%CI 1.14-1.44], P < 0.001), gastrointestinal bleeding (OR 1.56 [95%CI 1.48-1.64], P < 0.001) as well as necessity of transfusion of blood constituents (OR 2.94 [95%CI 2.88-3.00], P < 0.001) independently of important comorbidities. - Conclusions - The Kuijer score is an important risk stratification tool to predict individual risk regarding in-hospital outcomes comprising major bleeding events such as intracerebral bleeding and necessity of transfusion of blood constituents, but also in-hospital mortality and MACCE in VTE patients. | ||
| 534 | |c 2020 | ||
| 650 | 4 | |a Bleeding | |
| 650 | 4 | |a Deep venous thrombosis | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Pulmonary embolism | |
| 650 | 4 | |a Venous thromboembolism | |
| 700 | 1 | |a Münzel, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hobohm, Lukas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ostad, Mir A. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cardiology |d Amsterdam [u.a.] : Elsevier Science, 1981 |g 329(2021) vom: Apr., Seite 179-184 |h Online-Ressource |w (DE-627)306659581 |w (DE-600)1500478-8 |w (DE-576)081986270 |x 1874-1754 |7 nnas |a Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolism |
| 773 | 1 | 8 | |g volume:329 |g year:2021 |g month:04 |g pages:179-184 |g extent:6 |a Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolism |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijcard.2020.11.075 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0167527320342467 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210521 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 133143589 |a Keller, Karsten |m 133143589:Keller, Karsten |d 910000 |d 910100 |e 910000PK133143589 |e 910100PK133143589 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1758310464 |e 3930061627 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"recId":"306659581","pubHistory":["1.1981 -"],"id":{"eki":["306659581"],"issn":["1874-1754"],"zdb":["1500478-8"]},"disp":"Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolismInternational journal of cardiology","part":{"pages":"179-184","text":"329(2021) vom: Apr., Seite 179-184","year":"2021","volume":"329","extent":"6"},"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 13.02.20","Ungezählte Beil.: Supplement"],"origin":[{"publisher":"Elsevier Science","dateIssuedKey":"1981","dateIssuedDisp":"1981-","publisherPlace":"Amsterdam [u.a.]"}],"title":[{"title":"International journal of cardiology","title_sort":"International journal of cardiology"}],"language":["eng"]}],"id":{"doi":["10.1016/j.ijcard.2020.11.075"],"eki":["1758310464"]},"recId":"1758310464","name":{"displayForm":["Karsten Keller, Thomas Münzel, Lukas Hobohm, Mir A. Ostad"]},"physDesc":[{"extent":"6 S."}],"language":["eng"],"origin":[{"dateIssuedDisp":"2021","dateIssuedKey":"2021"}],"note":["Available online 8 December 2020","Gesehen am 21.05.2021"],"title":[{"title":"Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolism","title_sort":"Predictive value of the Kuijer score for bleeding and other adverse in-hospital events in patients with venous thromboembolism"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"display":"Keller, Karsten","family":"Keller","role":"aut","given":"Karsten"},{"display":"Münzel, Thomas","family":"Münzel","role":"aut","given":"Thomas"},{"display":"Hobohm, Lukas","family":"Hobohm","given":"Lukas","role":"aut"},{"given":"Mir A.","role":"aut","family":"Ostad","display":"Ostad, Mir A."}]} | ||
| SRT | |a KELLERKARSPREDICTIVE2021 | ||