Premature drug release of polymeric micelles and its effects on tumor targeting
Based on the enhanced permeability and retention (EPR) effect, nanoparticles are believed to accumulate in tumors. In this conjunction, the stability of drug encapsulation is assumed to be sufficient. For clarification purposes, PEGylated poly-(d,l-lactic acid) (PEG-PDLLA) micelles which incorporate...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 February 2013
|
| In: |
International journal of pharmaceutics
Year: 2013, Volume: 445, Issue: 1/2, Pages: 117-124 |
| ISSN: | 1873-3476 |
| DOI: | 10.1016/j.ijpharm.2013.01.059 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijpharm.2013.01.059 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0378517313001105 
|
| Author Notes: | Tobias Miller, Sandra Breyer, Gwenaelle van Colen, Walter Mier, Uwe Haberkorn, Simon Geissler, Senta Voss, Markus Weigandt, Achim Goepferich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1758396040 | ||
| 003 | DE-627 | ||
| 005 | 20230427100814.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210525s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijpharm.2013.01.059 |2 doi | |
| 035 | |a (DE-627)1758396040 | ||
| 035 | |a (DE-599)KXP1758396040 | ||
| 035 | |a (OCoLC)1341413725 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Miller, Tobias |d 1984- |e VerfasserIn |0 (DE-588)102436819X |0 (DE-627)719793564 |0 (DE-576)368374092 |4 aut | |
| 245 | 1 | 0 | |a Premature drug release of polymeric micelles and its effects on tumor targeting |c Tobias Miller, Sandra Breyer, Gwenaelle van Colen, Walter Mier, Uwe Haberkorn, Simon Geissler, Senta Voss, Markus Weigandt, Achim Goepferich |
| 264 | 1 | |c 4 February 2013 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.05.2021 | ||
| 520 | |a Based on the enhanced permeability and retention (EPR) effect, nanoparticles are believed to accumulate in tumors. In this conjunction, the stability of drug encapsulation is assumed to be sufficient. For clarification purposes, PEGylated poly-(d,l-lactic acid) (PEG-PDLLA) micelles which incorporated the hydrophobic model drug dechloro-4-iodo-fenofibrate (IFF) were investigated. H2N-PEG-PDLLA was synthesized, coupled to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and labeled with 111-indium. From this polymeric species, mixed micelles with H3CO-PEG-PDLLA were prepared which encapsulated the 125-iodine or 131-iodine labeled drug IFF. Bioimaging and biodistribution experiments in healthy and AR42J-tumor bearing mice were carried out to quantify the uptake of the drug and its carrier in single organs. As a result, upon injection of this system, a rapid dissociation of the polymeric carrier and the incorporated drug (<10min post inj.) was revealed. Regardless of the premature release, the drug showed an enhanced tumor accumulation compared to the polymeric carrier. In conclusion, the self-assembling system allowed for successful solubilization of the hydrophobic drug by physical incorporation into micelles whereas the tumor targeting properties of the drug delivery system could not be sufficiently shown. | ||
| 650 | 4 | |a Bioimaging | |
| 650 | 4 | |a EPR effect | |
| 650 | 4 | |a Organ distribution | |
| 650 | 4 | |a Polymeric micelles | |
| 650 | 4 | |a Premature release | |
| 650 | 4 | |a Tumor accumulation | |
| 700 | 1 | |a Breyer, Sandra |e VerfasserIn |0 (DE-588)143444603 |0 (DE-627)654311528 |0 (DE-576)338571043 |4 aut | |
| 700 | 1 | |a van Colen, Gwenaelle |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mier, Walter |d 1966- |e VerfasserIn |0 (DE-588)12029026X |0 (DE-627)69653567X |0 (DE-576)292141599 |4 aut | |
| 700 | 1 | |a Haberkorn, Uwe |d 1959- |e VerfasserIn |0 (DE-588)1022913905 |0 (DE-627)717331245 |0 (DE-576)366166352 |4 aut | |
| 700 | 1 | |a Geissler, Simon |e VerfasserIn |4 aut | |
| 700 | 1 | |a Voss, Senta |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weigandt, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Goepferich, Achim |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of pharmaceutics |d New York, NY [u.a.] : Elsevier, 1978 |g 445(2013), 1/2, Seite 117-124 |h Online-Ressource |w (DE-627)301512817 |w (DE-600)1484643-3 |w (DE-576)081952708 |x 1873-3476 |7 nnas |a Premature drug release of polymeric micelles and its effects on tumor targeting |
| 773 | 1 | 8 | |g volume:445 |g year:2013 |g number:1/2 |g pages:117-124 |g extent:8 |a Premature drug release of polymeric micelles and its effects on tumor targeting |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijpharm.2013.01.059 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0378517313001105 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210525 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1022913905 |a Haberkorn, Uwe |m 1022913905:Haberkorn, Uwe |d 910000 |d 911400 |e 910000PH1022913905 |e 911400PH1022913905 |k 0/910000/ |k 1/910000/911400/ |p 5 | ||
| 998 | |g 12029026X |a Mier, Walter |m 12029026X:Mier, Walter |d 910000 |d 911400 |e 910000PM12029026X |e 911400PM12029026X |k 0/910000/ |k 1/910000/911400/ |p 4 | ||
| 998 | |g 143444603 |a Breyer, Sandra |m 143444603:Breyer, Sandra |p 2 | ||
| 999 | |a KXP-PPN1758396040 |e 3930640082 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"note":["Gesehen am 25.05.2021"],"person":[{"given":"Tobias","display":"Miller, Tobias","role":"aut","family":"Miller"},{"display":"Breyer, Sandra","given":"Sandra","family":"Breyer","role":"aut"},{"role":"aut","family":"van Colen","given":"Gwenaelle","display":"van Colen, Gwenaelle"},{"family":"Mier","role":"aut","given":"Walter","display":"Mier, Walter"},{"given":"Uwe","display":"Haberkorn, Uwe","role":"aut","family":"Haberkorn"},{"given":"Simon","display":"Geissler, Simon","family":"Geissler","role":"aut"},{"given":"Senta","display":"Voss, Senta","role":"aut","family":"Voss"},{"role":"aut","family":"Weigandt","given":"Markus","display":"Weigandt, Markus"},{"display":"Goepferich, Achim","given":"Achim","family":"Goepferich","role":"aut"}],"recId":"1758396040","name":{"displayForm":["Tobias Miller, Sandra Breyer, Gwenaelle van Colen, Walter Mier, Uwe Haberkorn, Simon Geissler, Senta Voss, Markus Weigandt, Achim Goepferich"]},"language":["eng"],"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"4 February 2013"}],"relHost":[{"recId":"301512817","title":[{"title_sort":"International journal of pharmaceutics","title":"International journal of pharmaceutics"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1873-3476"],"eki":["301512817"],"zdb":["1484643-3"]},"origin":[{"publisher":"Elsevier","dateIssuedDisp":"1978-","dateIssuedKey":"1978","publisherPlace":"New York, NY [u.a.]"}],"language":["eng"],"part":{"issue":"1/2","pages":"117-124","extent":"8","text":"445(2013), 1/2, Seite 117-124","volume":"445","year":"2013"},"pubHistory":["1.1978 -"],"note":["Gesehen am 23.09.2021"],"disp":"Premature drug release of polymeric micelles and its effects on tumor targetingInternational journal of pharmaceutics","type":{"bibl":"periodical","media":"Online-Ressource"}}],"id":{"eki":["1758396040"],"doi":["10.1016/j.ijpharm.2013.01.059"]},"physDesc":[{"extent":"8 S."}],"title":[{"title_sort":"Premature drug release of polymeric micelles and its effects on tumor targeting","title":"Premature drug release of polymeric micelles and its effects on tumor targeting"}],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a MILLERTOBIPREMATURED4201 | ||