The glycome of normal and malignant plasma cells
The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcrip...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
December 26, 2013
|
| In: |
PLOS ONE
Year: 2013, Jahrgang: 8, Heft: 12, Pages: 1-13 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0083719 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1371/journal.pone.0083719 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083719 
|
| Verfasserangaben: | Thomas M. Moehler, Anja Seckinger, Dirk Hose, Mindaugas Andrulis, Jèrôme Moreaux, Thomas Hielscher, Martina Willhauck-Fleckenstein, Anette Merling, Uta Bertsch, Anna Jauch, Hartmut Goldschmidt, Bernard Klein, Reinhard Schwartz-Albiez |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1758403357 | ||
| 003 | DE-627 | ||
| 005 | 20220819213510.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210525s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0083719 |2 doi | |
| 035 | |a (DE-627)1758403357 | ||
| 035 | |a (DE-599)KXP1758403357 | ||
| 035 | |a (OCoLC)1341413828 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Möhler, Thomas |e VerfasserIn |0 (DE-588)1014877261 |0 (DE-627)705298051 |0 (DE-576)34979572X |4 aut | |
| 245 | 1 | 4 | |a The glycome of normal and malignant plasma cells |c Thomas M. Moehler, Anja Seckinger, Dirk Hose, Mindaugas Andrulis, Jèrôme Moreaux, Thomas Hielscher, Martina Willhauck-Fleckenstein, Anette Merling, Uta Bertsch, Anna Jauch, Hartmut Goldschmidt, Bernard Klein, Reinhard Schwartz-Albiez |
| 264 | 1 | |c December 26, 2013 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.05.2021 | ||
| 520 | |a The glycome, i.e. the cellular repertoire of glycan structures, contributes to important functions such as adhesion and intercellular communication. Enzymes regulating cellular glycosylation processes are related to the pathogenesis of cancer including multiple myeloma. Here we analyze the transcriptional differences in the glycome of normal (n = 10) and two cohorts of 332 and 345 malignant plasma-cell samples, association with known multiple myeloma subentities as defined by presence of chromosomal aberrations, potential therapeutic targets, and its prognostic impact. We found i) malignant vs. normal plasma cells to show a characteristic glycome-signature. They can ii) be delineated by a lasso-based predictor from normal plasma cells based on this signature. iii) Cytogenetic aberrations lead to distinct glycan-gene expression patterns for t(11;14), t(4;14), hyperdiploidy, 1q21-gain and deletion of 13q14. iv) A 38-gene glycome-signature significantly delineates patients with adverse survival in two independent cohorts of 545 patients treated with high-dose melphalan and autologous stem cell transplantation. v) As single gene, expression of the phosphatidyl-inositol-glycan protein M as part of the targetable glycosyl-phosphatidyl-inositol-anchor-biosynthesis pathway is associated with adverse survival. The prognostically relevant glycome deviation in malignant cells invites novel strategies of therapy for multiple myeloma. | ||
| 650 | 4 | |a Biosynthesis | |
| 650 | 4 | |a Bone marrow cells | |
| 650 | 4 | |a Gene expression | |
| 650 | 4 | |a Glycosylation | |
| 650 | 4 | |a Multiple myeloma | |
| 650 | 4 | |a Myeloma cells | |
| 650 | 4 | |a Plasma cells | |
| 650 | 4 | |a Sulfates | |
| 700 | 1 | |a Seckinger, Anja |d 1980- |e VerfasserIn |0 (DE-588)134177371 |0 (DE-627)562118225 |0 (DE-576)278603734 |4 aut | |
| 700 | 1 | |a Hose, Dirk |d 1969- |e VerfasserIn |0 (DE-588)139824995 |0 (DE-627)613790308 |0 (DE-576)313431698 |4 aut | |
| 700 | 1 | |a Andrulis, Mindaugas |d 1972- |e VerfasserIn |0 (DE-588)131682172 |0 (DE-627)512716587 |0 (DE-576)298670534 |4 aut | |
| 700 | 1 | |a Moreaux, Jèrôme |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hielscher, Thomas |e VerfasserIn |0 (DE-588)1159594791 |0 (DE-627)1022977768 |0 (DE-576)50506068X |4 aut | |
| 700 | 1 | |a Willhauck-Fleckenstein, Martina |d 1963- |e VerfasserIn |0 (DE-588)115403671 |0 (DE-627)691290784 |0 (DE-576)289862906 |4 aut | |
| 700 | 1 | |a Merling, Anette |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bertsch, Uta |e VerfasserIn |0 (DE-588)1026849861 |0 (DE-627)727494163 |0 (DE-576)372176224 |4 aut | |
| 700 | 1 | |a Jauch, Anna |d 1959- |e VerfasserIn |0 (DE-588)1025525140 |0 (DE-627)722525362 |0 (DE-576)168357496 |4 aut | |
| 700 | 1 | |a Goldschmidt, Hartmut |d 1956- |e VerfasserIn |0 (DE-588)102258023X |0 (DE-627)717003809 |0 (DE-576)365637386 |4 aut | |
| 700 | 1 | |a Klein, Bernard |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwartz-Albiez, Reinhard |e VerfasserIn |0 (DE-588)1112496106 |0 (DE-627)866475532 |0 (DE-576)169948390 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 8(2013), 12, Artikel-ID e83719, Seite 1-13 |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a The glycome of normal and malignant plasma cells |
| 773 | 1 | 8 | |g volume:8 |g year:2013 |g number:12 |g elocationid:e83719 |g pages:1-13 |g extent:13 |a The glycome of normal and malignant plasma cells |
| 856 | 4 | 0 | |u https://doi.org/10.1371/journal.pone.0083719 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0083719 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210525 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1112496106 |a Schwartz-Albiez, Reinhard |m 1112496106:Schwartz-Albiez, Reinhard |d 50000 |e 50000PS1112496106 |k 0/50000/ |p 13 |y j | ||
| 998 | |g 102258023X |a Goldschmidt, Hartmut |m 102258023X:Goldschmidt, Hartmut |d 910000 |d 910100 |d 50000 |e 910000PG102258023X |e 910100PG102258023X |e 50000PG102258023X |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 11 | ||
| 998 | |g 1025525140 |a Jauch, Anna |m 1025525140:Jauch, Anna |d 910000 |d 911500 |d 50000 |e 910000PJ1025525140 |e 911500PJ1025525140 |e 50000PJ1025525140 |k 0/910000/ |k 1/910000/911500/ |k 0/50000/ |p 10 | ||
| 998 | |g 1026849861 |a Bertsch, Uta |m 1026849861:Bertsch, Uta |d 910000 |d 910100 |e 910000PB1026849861 |e 910100PB1026849861 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 1159594791 |a Hielscher, Thomas |m 1159594791:Hielscher, Thomas |d 140000 |e 140000PH1159594791 |k 0/140000/ |p 6 | ||
| 998 | |g 131682172 |a Andrulis, Mindaugas |m 131682172:Andrulis, Mindaugas |d 910000 |d 912000 |e 910000PA131682172 |e 912000PA131682172 |k 0/910000/ |k 1/910000/912000/ |p 4 | ||
| 998 | |g 139824995 |a Hose, Dirk |m 139824995:Hose, Dirk |d 910000 |d 910100 |e 910000PH139824995 |e 910100PH139824995 |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 134177371 |a Seckinger, Anja |m 134177371:Seckinger, Anja |d 910000 |d 910100 |e 910000PS134177371 |e 910100PS134177371 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1014877261 |a Möhler, Thomas |m 1014877261:Möhler, Thomas |d 910000 |d 910100 |e 910000PM1014877261 |e 910100PM1014877261 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1758403357 |e 3930655691 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Thomas M. Moehler, Anja Seckinger, Dirk Hose, Mindaugas Andrulis, Jèrôme Moreaux, Thomas Hielscher, Martina Willhauck-Fleckenstein, Anette Merling, Uta Bertsch, Anna Jauch, Hartmut Goldschmidt, Bernard Klein, Reinhard Schwartz-Albiez"]},"physDesc":[{"extent":"13 S."}],"relHost":[{"corporate":[{"display":"Public Library of Science","role":"isb"}],"part":{"issue":"12","text":"8(2013), 12, Artikel-ID e83719, Seite 1-13","pages":"1-13","year":"2013","extent":"13","volume":"8"},"language":["eng"],"disp":"The glycome of normal and malignant plasma cellsPLOS ONE","type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}],"note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"pubHistory":["1.2006 -"],"origin":[{"publisherPlace":"San Francisco, California, US ; Lawrence, Kan.","dateIssuedDisp":"2006-","dateIssuedKey":"2006","publisher":"PLOS ; PLoS"}],"id":{"issn":["1932-6203"],"zdb":["2267670-3"],"eki":["523574592"]},"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Public Library of Science"]},"recId":"523574592"}],"recId":"1758403357","id":{"doi":["10.1371/journal.pone.0083719"],"eki":["1758403357"]},"note":["Gesehen am 25.05.2021"],"origin":[{"dateIssuedDisp":"December 26, 2013","dateIssuedKey":"2013"}],"title":[{"title":"The glycome of normal and malignant plasma cells","title_sort":"glycome of normal and malignant plasma cells"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"person":[{"role":"aut","given":"Thomas","family":"Möhler","display":"Möhler, Thomas"},{"role":"aut","given":"Anja","family":"Seckinger","display":"Seckinger, Anja"},{"family":"Hose","display":"Hose, Dirk","role":"aut","given":"Dirk"},{"family":"Andrulis","display":"Andrulis, Mindaugas","given":"Mindaugas","role":"aut"},{"role":"aut","given":"Jèrôme","family":"Moreaux","display":"Moreaux, Jèrôme"},{"given":"Thomas","role":"aut","display":"Hielscher, Thomas","family":"Hielscher"},{"family":"Willhauck-Fleckenstein","display":"Willhauck-Fleckenstein, Martina","role":"aut","given":"Martina"},{"family":"Merling","display":"Merling, Anette","given":"Anette","role":"aut"},{"display":"Bertsch, Uta","family":"Bertsch","role":"aut","given":"Uta"},{"given":"Anna","role":"aut","display":"Jauch, Anna","family":"Jauch"},{"family":"Goldschmidt","display":"Goldschmidt, Hartmut","given":"Hartmut","role":"aut"},{"display":"Klein, Bernard","family":"Klein","given":"Bernard","role":"aut"},{"given":"Reinhard","role":"aut","display":"Schwartz-Albiez, Reinhard","family":"Schwartz-Albiez"}]} | ||
| SRT | |a MOEHLERTHOGLYCOMEOFN2620 | ||