Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction
It is well acknowledged that genetic variation accounts for the intra-species variability in Staphylococcus aureus isolates. Similarly, deficiency in DNA repair and the resulting increase in genomic mutations determine intra-strain variability in S. aureus small colony variants (SCV). The aim of thi...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 January 2013
|
| In: |
International journal of medical microbiology
Year: 2013, Jahrgang: 303, Heft: 2, Pages: 61-69 |
| ISSN: | 1618-0607 |
| DOI: | 10.1016/j.ijmm.2012.12.008 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ijmm.2012.12.008 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1438422113000039 
|
| Verfasserangaben: | Dina Hilmi, Marijo Parcina, Konrad Bode, Jenny Ostrop, Sabine Schuett, Klaus Heeg, Wilma Ziebuhr, Olaf Sommerburg, Isabelle Bekeredjian-Ding |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1758459654 | ||
| 003 | DE-627 | ||
| 005 | 20220819213825.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210525s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ijmm.2012.12.008 |2 doi | |
| 035 | |a (DE-627)1758459654 | ||
| 035 | |a (DE-599)KXP1758459654 | ||
| 035 | |a (OCoLC)1341413986 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hilmi, Dina |d 1983- |e VerfasserIn |0 (DE-588)1033923540 |0 (DE-627)74367474X |0 (DE-576)381604969 |4 aut | |
| 245 | 1 | 0 | |a Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction |c Dina Hilmi, Marijo Parcina, Konrad Bode, Jenny Ostrop, Sabine Schuett, Klaus Heeg, Wilma Ziebuhr, Olaf Sommerburg, Isabelle Bekeredjian-Ding |
| 264 | 1 | |c 29 January 2013 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.05.2021 | ||
| 520 | |a It is well acknowledged that genetic variation accounts for the intra-species variability in Staphylococcus aureus isolates. Similarly, deficiency in DNA repair and the resulting increase in genomic mutations determine intra-strain variability in S. aureus small colony variants (SCV). The aim of this study was to investigate whether intra-strain diversity would be associated with an alteration of the host-pathogen interaction. To this end, biofilm formation and immune stimulatory capacity were compared in consecutive SCV isolates originating from a single patient. Despite the relatedness of the isolates, the results revealed significant differences in biofilm formation and immune stimulation determined by Toll-like receptor-2 (TLR2) activity. Variation in the extent of biofilm production could be attributed to differences in the expression of protein A (SpA) and agrA. TLR2 activity only partially correlated with these parameters. Although transiently increased functional activity correlated with clinical remission and was abrogated in MRSA superinfection, we can only speculate that changes in the SCV phenotype reflect alterations in the microbial environment and/or treatment. Taken together, our study provides in vivo evidence for the functional consequences of intra-strain variation in S. aureus. | ||
| 650 | 4 | |a Biofilm | |
| 650 | 4 | |a Intrastrain variability | |
| 650 | 4 | |a Protein A | |
| 650 | 4 | |a Small colony variants | |
| 650 | 4 | |a TLR2 | |
| 700 | 1 | |a Parčina, Marijo |d 1981- |e VerfasserIn |0 (DE-588)1014441102 |0 (DE-627)705233464 |0 (DE-576)348206283 |4 aut | |
| 700 | 1 | |a Bode, Konrad A. |d 1969- |e VerfasserIn |0 (DE-588)128891270 |0 (DE-627)384629334 |0 (DE-576)297385836 |4 aut | |
| 700 | 1 | |a Ostrop, Jenny |d 1988- |e VerfasserIn |0 (DE-588)1075290104 |0 (DE-627)833581368 |0 (DE-576)44336804X |4 aut | |
| 700 | 1 | |a Schuett, Sabine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Heeg, Klaus |d 1956- |e VerfasserIn |0 (DE-588)133238369 |0 (DE-627)539308587 |0 (DE-576)299716805 |4 aut | |
| 700 | 1 | |a Ziebuhr, Wilma |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sommerburg, Olaf |d 1967- |e VerfasserIn |0 (DE-588)172907470 |0 (DE-627)69783543X |0 (DE-576)133762270 |4 aut | |
| 700 | 1 | |a Bekeredjian-Ding, Isabelle |d 1974- |e VerfasserIn |0 (DE-588)12425392X |0 (DE-627)085739456 |0 (DE-576)294089659 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of medical microbiology |d München : Elsevier, 2000 |g 303(2013), 2, Seite 61-69 |h Online-Ressource |w (DE-627)320603938 |w (DE-600)2020515-6 |w (DE-576)094478945 |x 1618-0607 |7 nnas |a Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction |
| 773 | 1 | 8 | |g volume:303 |g year:2013 |g number:2 |g pages:61-69 |g extent:9 |a Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ijmm.2012.12.008 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1438422113000039 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210525 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 12425392X |a Bekeredjian-Ding, Isabelle |m 12425392X:Bekeredjian-Ding, Isabelle |d 50000 |e 50000PB12425392X |k 0/50000/ |p 9 |y j | ||
| 998 | |g 172907470 |a Sommerburg, Olaf |m 172907470:Sommerburg, Olaf |d 910000 |d 910500 |e 910000PS172907470 |e 910500PS172907470 |k 0/910000/ |k 1/910000/910500/ |p 8 | ||
| 998 | |g 133238369 |a Heeg, Klaus |m 133238369:Heeg, Klaus |d 910000 |d 911700 |e 910000PH133238369 |e 911700PH133238369 |k 0/910000/ |k 1/910000/911700/ |p 6 | ||
| 998 | |g 1075290104 |a Ostrop, Jenny |m 1075290104:Ostrop, Jenny |p 4 | ||
| 998 | |g 128891270 |a Bode, Konrad A. |m 128891270:Bode, Konrad A. |d 50000 |e 50000PB128891270 |k 0/50000/ |p 3 | ||
| 998 | |g 1014441102 |a Parčina, Marijo |m 1014441102:Parčina, Marijo |d 910000 |d 911700 |e 910000PP1014441102 |e 911700PP1014441102 |k 0/910000/ |k 1/910000/911700/ |p 2 | ||
| 998 | |g 1033923540 |a Hilmi, Dina |m 1033923540:Hilmi, Dina |d 910000 |d 911700 |e 910000PH1033923540 |e 911700PH1033923540 |k 0/910000/ |k 1/910000/911700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1758459654 |e 3930771683 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"role":"aut","given":"Dina","family":"Hilmi","display":"Hilmi, Dina"},{"family":"Parčina","display":"Parčina, Marijo","role":"aut","given":"Marijo"},{"family":"Bode","display":"Bode, Konrad A.","role":"aut","given":"Konrad A."},{"given":"Jenny","role":"aut","family":"Ostrop","display":"Ostrop, Jenny"},{"family":"Schuett","display":"Schuett, Sabine","role":"aut","given":"Sabine"},{"role":"aut","given":"Klaus","family":"Heeg","display":"Heeg, Klaus"},{"display":"Ziebuhr, Wilma","family":"Ziebuhr","role":"aut","given":"Wilma"},{"family":"Sommerburg","display":"Sommerburg, Olaf","role":"aut","given":"Olaf"},{"role":"aut","given":"Isabelle","family":"Bekeredjian-Ding","display":"Bekeredjian-Ding, Isabelle"}],"physDesc":[{"extent":"9 S."}],"name":{"displayForm":["Dina Hilmi, Marijo Parcina, Konrad Bode, Jenny Ostrop, Sabine Schuett, Klaus Heeg, Wilma Ziebuhr, Olaf Sommerburg, Isabelle Bekeredjian-Ding"]},"recId":"1758459654","relHost":[{"language":["eng"],"titleAlt":[{"title":"IJMM"}],"part":{"pages":"61-69","year":"2013","issue":"2","text":"303(2013), 2, Seite 61-69","volume":"303","extent":"9"},"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["Deutsche Gesellschaft für Hygiene und Mikrobiologie"]},"recId":"320603938","id":{"zdb":["2020515-6"],"issn":["1618-0607"],"eki":["320603938"]},"title":[{"title":"International journal of medical microbiology","subtitle":"IJMM","title_sort":"International journal of medical microbiology"}],"pubHistory":["290.2000/01 -"],"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 17.05.2021"],"origin":[{"dateIssuedDisp":"2000-","dateIssuedKey":"2000","publisher":"Elsevier ; Urban & Fischer","publisherPlace":"München ; Jena"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interactionInternational journal of medical microbiology"}],"id":{"doi":["10.1016/j.ijmm.2012.12.008"],"eki":["1758459654"]},"title":[{"title":"Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction","title_sort":"Functional variation reflects intra-strain diversity of Staphylococcus aureus small colony variants in the host-pathogen interaction"}],"origin":[{"dateIssuedDisp":"29 January 2013","dateIssuedKey":"2013"}],"note":["Gesehen am 25.05.2021"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a HILMIDINAPFUNCTIONAL2920 | ||