Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine and human tissue Treg cells defined a conserved,...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 30, 2021
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| In: |
Immunity
Year: 2021, Jahrgang: 54, Heft: 4 |
| ISSN: | 1097-4180 |
| DOI: | 10.1016/j.immuni.2021.03.007 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.immuni.2021.03.007 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1074761321001199 
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| Verfasserangaben: | Michael Delacher, Malte Simon, Lieke Sanderink, Agnes Hotz-Wagenblatt, Marina Wuttke, Kathrin Schambeck, Lisa Schmidleithner, Sebastian Bittner, Asmita Pant, Uwe Ritter, Thomas Hehlgans, Dania Riegel, Verena Schneider, Florian Kai Groeber-Becker, Andreas Eigenberger, Claudia Gebhard, Nicholas Strieder, Alexander Fischer, Michael Rehli, Petra Hoffmann, Matthias Edinger, Till Strowig, Jochen Huehn, Christian Schmidl, Jens M. Werner, Lukas Prantl, Benedikt Brors, Charles D. Imbusch, and Markus Feuerer |
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| 245 | 1 | 0 | |a Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells |c Michael Delacher, Malte Simon, Lieke Sanderink, Agnes Hotz-Wagenblatt, Marina Wuttke, Kathrin Schambeck, Lisa Schmidleithner, Sebastian Bittner, Asmita Pant, Uwe Ritter, Thomas Hehlgans, Dania Riegel, Verena Schneider, Florian Kai Groeber-Becker, Andreas Eigenberger, Claudia Gebhard, Nicholas Strieder, Alexander Fischer, Michael Rehli, Petra Hoffmann, Matthias Edinger, Till Strowig, Jochen Huehn, Christian Schmidl, Jens M. Werner, Lukas Prantl, Benedikt Brors, Charles D. Imbusch, and Markus Feuerer |
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| 520 | |a Murine regulatory T (Treg) cells in tissues promote tissue homeostasis and regeneration. We sought to identify features that characterize human Treg cells with these functions in healthy tissues. Single-cell chromatin accessibility profiles of murine and human tissue Treg cells defined a conserved, microbiota-independent tissue-repair Treg signature with a prevailing footprint of the transcription factor BATF. This signature, combined with gene expression profiling and TCR fate mapping, identified a population of tissue-like Treg cells in human peripheral blood that expressed BATF, chemokine receptor CCR8 and HLA-DR. Human BATF+CCR8+ Treg cells from normal skin and adipose tissue shared features with nonlymphoid T follicular helper-like (Tfh-like) cells, and induction of a Tfh-like differentiation program in naive human Treg cells partially recapitulated tissue Treg regenerative characteristics, including wound healing potential. Human BATF+CCR8+ Treg cells from healthy tissue share features with tumor-resident Treg cells, highlighting the importance of understanding the context-specific functions of these cells. | ||
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