Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy: results of the VITAL study
Background - Chronic kidney disease (CKD) is associated with elevations in serum phosphate, calcium-phosphorus product and bone-specific alkaline phosphatase (BAP), with attendant risks of cardiovascular and bone disorders. Active vitamin D can suppress parathyroid hormone (PTH), but may raise serum...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
19 June 2013
|
| In: |
Nephrology, dialysis, transplantation
Year: 2013, Volume: 28, Issue: 9, Pages: 2260-2268 |
| ISSN: | 1460-2385 |
| DOI: | 10.1093/ndt/gft227 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ndt/gft227 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769981/ 
|
| Author Notes: | Daniel W. Coyne, Dennis L. Andress, Michael J. Amdahl, Eberhard Ritz and Dick de Zeeuw |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1759072869 | ||
| 003 | DE-627 | ||
| 005 | 20220819215653.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210527s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ndt/gft227 |2 doi | |
| 035 | |a (DE-627)1759072869 | ||
| 035 | |a (DE-599)KXP1759072869 | ||
| 035 | |a (OCoLC)1341414778 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Coyne, Daniel W. |e VerfasserIn |0 (DE-588)1234183692 |0 (DE-627)1759072656 |4 aut | |
| 245 | 1 | 0 | |a Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy |b results of the VITAL study |c Daniel W. Coyne, Dennis L. Andress, Michael J. Amdahl, Eberhard Ritz and Dick de Zeeuw |
| 264 | 1 | |c 19 June 2013 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 27.05.2021 | ||
| 520 | |a Background - Chronic kidney disease (CKD) is associated with elevations in serum phosphate, calcium-phosphorus product and bone-specific alkaline phosphatase (BAP), with attendant risks of cardiovascular and bone disorders. Active vitamin D can suppress parathyroid hormone (PTH), but may raise serum calcium and phosphate concentrations. Paricalcitol, a selective vitamin D activator, suppressed PTH in CKD patients (stages 3 and 4) with secondary hyperparathyroidism (SHPT) with minimal changes in calcium and phosphate metabolism. - - Methods - The VITAL study enrolled patients with CKD stages 2-4. We examined the effect and relationship of paricalcitol to calcium and phosphate metabolism and bone markers in a post hoc analysis of VITAL. The study comprised patients with diabetic nephropathy enrolled in a double-blind, placebo-controlled, randomized trial of paricalcitol (1 or 2 μg/day). Urinary and serum calcium and phosphate, serum BAP, and intact PTH (iPTH) concentrations were measured throughout the study. - - Results - Baseline demographics and calcium, phosphate, PTH (49% with iPTH <70 pg/mL), and BAP concentrations were similar between groups. A transient, modest yet significant increase in phosphate was observed for paricalcitol 2 μg/day (+0.29 mg/dL; P < 0.001). Dose-dependent increases in serum and urinary calcium were observed; however, there were few cases of hypercalcemia: one in the 1-μg/day group (1.1%) and three in the 2-μg/day group (3.2%). Significant reductions in BAP were observed that persisted for 60 days after paricalcitol discontinuation (P < 0.001 for combined paricalcitol groups versus placebo). Paricalcitol dose-dependent reductions in iPTH were observed. Paricalcitol in CKD patients (±SHPT) was associated with modest increases in calcium and phosphate. - - Conclusion - Paricalcitol reduces BAP levels, which may be beneficial for reducing vascular calcification. - - Trial registration - Trial is registered with ClinicalTrials.gov, number NCT00421733. | ||
| 700 | 1 | |a Andress, Dennis L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Amdahl, Michael J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ritz, Eberhard |d 1938-2023 |e VerfasserIn |0 (DE-588)106673386 |0 (DE-627)610528866 |0 (DE-576)311552501 |4 aut | |
| 700 | 1 | |a de Zeeuw, Dick |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nephrology, dialysis, transplantation |d Oxford : Oxford Univ. Press, 1986 |g 28(2013), 9, Seite 2260-2268 |h Online-Ressource |w (DE-627)265778395 |w (DE-600)1465709-0 |w (DE-576)079420079 |x 1460-2385 |7 nnas |a Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy results of the VITAL study |
| 773 | 1 | 8 | |g volume:28 |g year:2013 |g number:9 |g pages:2260-2268 |g extent:9 |a Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy results of the VITAL study |
| 856 | 4 | 0 | |u https://doi.org/10.1093/ndt/gft227 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3769981/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210527 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 106673386 |a Ritz, Eberhard |m 106673386:Ritz, Eberhard |d 910000 |d 910100 |e 910000PR106673386 |e 910100PR106673386 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 999 | |a KXP-PPN1759072869 |e 3931842894 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Daniel W. Coyne, Dennis L. Andress, Michael J. Amdahl, Eberhard Ritz and Dick de Zeeuw"]},"origin":[{"dateIssuedDisp":"19 June 2013","dateIssuedKey":"2013"}],"id":{"eki":["1759072869"],"doi":["10.1093/ndt/gft227"]},"physDesc":[{"extent":"9 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1986-","publisher":"Oxford Univ. Press","dateIssuedKey":"1986","publisherPlace":"Oxford"}],"id":{"eki":["265778395"],"zdb":["1465709-0"],"issn":["1460-2385"]},"pubHistory":["1.1986 -"],"part":{"extent":"9","volume":"28","text":"28(2013), 9, Seite 2260-2268","issue":"9","pages":"2260-2268","year":"2013"},"titleAlt":[{"title":"Nephrology, dialysis, transplantation online"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy results of the VITAL studyNephrology, dialysis, transplantation","note":["Gesehen am 01-04-14"],"language":["eng"],"recId":"265778395","title":[{"title_sort":"Nephrology, dialysis, transplantation","title":"Nephrology, dialysis, transplantation"}]}],"person":[{"display":"Coyne, Daniel W.","roleDisplay":"VerfasserIn","role":"aut","family":"Coyne","given":"Daniel W."},{"display":"Andress, Dennis L.","roleDisplay":"VerfasserIn","role":"aut","family":"Andress","given":"Dennis L."},{"given":"Michael J.","family":"Amdahl","role":"aut","roleDisplay":"VerfasserIn","display":"Amdahl, Michael J."},{"family":"Ritz","given":"Eberhard","roleDisplay":"VerfasserIn","display":"Ritz, Eberhard","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"de Zeeuw, Dick","given":"Dick","family":"de Zeeuw"}],"title":[{"title":"Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy","subtitle":"results of the VITAL study","title_sort":"Effects of paricalcitol on calcium and phosphate metabolism and markers of bone health in patients with diabetic nephropathy"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 27.05.2021"],"language":["eng"],"recId":"1759072869"} | ||
| SRT | |a COYNEDANIEEFFECTSOFP1920 | ||