Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB

Increased oxidative stress and subsequent activation of the transcription factor NF-kB has been linked to the development of late diabetic complications. To determine whether oxidative stress dependent NF-kB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobil...

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Main Authors: Hofmann Bowman, Marion (Author) , Schiekofer, Stephan (Author) , Isermann, Berend (Author) , Kanitz, Michael (Author) , Henkels, M. (Author) , Joswig, M. (Author) , Treusch, A. (Author) , Morcos, Michael (Author) , Weiss, T. (Author) , Borcea, Valentin (Author) , Abdel-Khalek, Mohamed (Author) , Amiral, Jean (Author) , Tritschler, Hans (Author) , Ritz, Eberhard (Author) , Wahl, Peter (Author) , Ziegler, Reinhard (Author) , Bierhaus, Angelika (Author) , Nawroth, Peter Paul (Author)
Format: Article (Journal)
Language:English
Published: 1999
In: Diabetologia
Year: 1999, Volume: 42, Issue: 2, Pages: 222-232
ISSN:1432-0428
DOI:10.1007/s001250051142
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s001250051142
Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s001250051142
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Author Notes:M.A. Hofmann, S. Schiekofer, B. Isermann, M. Kanitz, M. Henkels, M. Joswig, A. Treusch, M. Morcos, T. Weiss, V. Borcea, A.K.M. Abdel Khalek, J. Amiral, H. Tritschler, E. Ritz, P. Wahl, R. Ziegler, A. Bierhaus, P.P. Nawroth
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Summary:Increased oxidative stress and subsequent activation of the transcription factor NF-kB has been linked to the development of late diabetic complications. To determine whether oxidative stress dependent NF-kB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobility Shift Assay based semiquantitative detection system which enabled us to determine NF-kB activation in ex vivo isolated peripheral blood mononuclear cells.
Item Description:Gesehen am 28.05.2021
Physical Description:Online Resource
ISSN:1432-0428
DOI:10.1007/s001250051142