Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB
Increased oxidative stress and subsequent activation of the transcription factor NF-kB has been linked to the development of late diabetic complications. To determine whether oxidative stress dependent NF-kB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobil...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
1999
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| In: |
Diabetologia
Year: 1999, Volume: 42, Issue: 2, Pages: 222-232 |
| ISSN: | 1432-0428 |
| DOI: | 10.1007/s001250051142 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s001250051142 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s001250051142 
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| Author Notes: | M.A. Hofmann, S. Schiekofer, B. Isermann, M. Kanitz, M. Henkels, M. Joswig, A. Treusch, M. Morcos, T. Weiss, V. Borcea, A.K.M. Abdel Khalek, J. Amiral, H. Tritschler, E. Ritz, P. Wahl, R. Ziegler, A. Bierhaus, P.P. Nawroth |
MARC
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| 245 | 1 | 0 | |a Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kB |c M.A. Hofmann, S. Schiekofer, B. Isermann, M. Kanitz, M. Henkels, M. Joswig, A. Treusch, M. Morcos, T. Weiss, V. Borcea, A.K.M. Abdel Khalek, J. Amiral, H. Tritschler, E. Ritz, P. Wahl, R. Ziegler, A. Bierhaus, P.P. Nawroth |
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| 520 | |a Increased oxidative stress and subsequent activation of the transcription factor NF-kB has been linked to the development of late diabetic complications. To determine whether oxidative stress dependent NF-kB activation is evident in patients with diabetic nephropathy we used an Electrophoretic Mobility Shift Assay based semiquantitative detection system which enabled us to determine NF-kB activation in ex vivo isolated peripheral blood mononuclear cells. | ||
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