Competition for G beta gamma dimers mediates a specific cross-talk between stimulatory and inhibitory G protein alpha subunits of the adenylyl cyclase in cardiomyocytes
Heterotrimeric G proteins are key regulators of signaling pathways in mammalian cells. Beyond G protein-coupled receptors, the amount and mutual ratio of specific G protein α, β, and γ subunits determine the G protein signaling. However, little is known about mechanisms that regulate the concentrati...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 April 2013
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| In: |
Naunyn-Schmiedeberg's archives of pharmacology
Year: 2013, Jahrgang: 386, Heft: 6, Pages: 459-469 |
| ISSN: | 1432-1912 |
| DOI: | 10.1007/s00210-013-0876-x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00210-013-0876-x |
| Verfasserangaben: | Hans-Jörg Hippe, Mark Lüdde, Katrin Schnoes, Ana Novakovic, Susanne Lutz, Hugo A. Katus, Feraydoon Niroomand, Bernd Nürnberg, Norbert Frey, Thomas Wieland |