Deleterious impact of mismatching for human leukocyte antigen-C in presensitized recipients of kidney transplants
BACKGROUND: Allocation of deceased donor kidneys is commonly based on matching for human leukocyte antigen (HLA)-A, -B, and -DR, whereas HLA-C is currently disregarded. We investigated the influence of HLA-C compatibility on renal allograft survival. In addition, we tested an approach of matching fo...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
Transplantation
Year: 2011, Jahrgang: 92, Heft: 4, Pages: 419-425 |
| ISSN: | 1534-6080 |
| DOI: | 10.1097/TP.0b013e318224c14e |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/TP.0b013e318224c14e Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/transplantjournal/Fulltext/2011/08270/Deleterious_Impact_of_Mismatching_for_Human.7.aspx 
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| Verfasserangaben: | Thuong Hien Tran, Bernd Döhler, Andreas Heinold, Sabine Scherer, Andrea Ruhenstroth, and Gerhard Opelz |
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| 245 | 1 | 0 | |a Deleterious impact of mismatching for human leukocyte antigen-C in presensitized recipients of kidney transplants |c Thuong Hien Tran, Bernd Döhler, Andreas Heinold, Sabine Scherer, Andrea Ruhenstroth, and Gerhard Opelz |
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| 520 | |a BACKGROUND: Allocation of deceased donor kidneys is commonly based on matching for human leukocyte antigen (HLA)-A, -B, and -DR, whereas HLA-C is currently disregarded. We investigated the influence of HLA-C compatibility on renal allograft survival. In addition, we tested an approach of matching for HLA-C epitopes. METHODS: A cohort of 2260 deceased donor kidney transplants were typed for HLA-C using polymerase chain reaction-sequence specific primer method. Samples for DNA typing, serum results on presensitization (lymphocytotoxicity), and clinical data were provided by transplant centers participating in the Collaborative Transplant Study. RESULTS: HLA-C mismatch was found to be associated with significantly decreased graft survival in presensitized (P<0.001) but not in non-presensitized (P=0.75) recipients. Mismatch of certain HLA-C epitopes seemed to be more influential than others, with mismatches showing a negative impact on graft survival in presensitized patients. CONCLUSIONS: HLA-C mismatch has a substantial deleterious effect on graft survival in presensitized kidney recipients. Our study points out the need for investigations directed at identifying donor-specific HLA-C antibodies and evaluating their relevance in transplantation. In view of the fact that current assays for determining HLA-C specific antibodies are hampered by additional detection of clinically irrelevant antibodies, matching for HLA-C may provide a reasonable approach to improve transplant outcomes in presensitized kidney transplant recipients. | ||
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| 650 | 4 | |a Epitopes | |
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| 650 | 4 | |a Graft Survival | |
| 650 | 4 | |a Histocompatibility Testing | |
| 650 | 4 | |a HLA-A Antigens | |
| 650 | 4 | |a HLA-B Antigens | |
| 650 | 4 | |a HLA-C Antigens | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Isoantibodies | |
| 650 | 4 | |a Kidney Transplantation | |
| 650 | 4 | |a Linkage Disequilibrium | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Time Factors | |
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