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Borrelia burgdorferi complement regulator-acquiring surface protein 1 of the Lyme disease spirochetes is expressed in humans and induces antibody responses restricted to nondenatured structural determinants

Borrelia burgdorferi complement regulator-acquiring surface protein 1 (CRASP-1), the dominant factor H and FHL-1-binding protein of the Lyme disease spirochete B. burgdorferi, is implicated in pathogen persistence and was recently reported to be nonimmunogenic in humans. Here we show that serum samp...

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Bibliographic Details
Main Authors: Rossmann, Evelyn (Author) , Kitiratschky, Véronique (Author) , Hofmann, Heidelore (Author) , Kraiczy, Peter (Author) , Simon, Markus (Author) , Wallich, Reinhard (Author)
Format: Article (Journal)
Language:English
Published: 25 September 2006
In: Infection and immunity
Year: 2006, Volume: 74, Issue: 12, Pages: 7024-7028
ISSN:1098-5522
DOI:10.1128/IAI.01028-06
Online Access:Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1128/IAI.01028-06
Verlag, lizenzpflichtig, Volltext: https://journals.asm.org/doi/epub/10.1128/IAI.01028-06
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Author Notes:Evelyn Rossmann, Veronique Kitiratschky, Heidelore Hofmann, Peter Kraiczy, Markus M. Simon, and Reinhard Wallich
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Summary:Borrelia burgdorferi complement regulator-acquiring surface protein 1 (CRASP-1), the dominant factor H and FHL-1-binding protein of the Lyme disease spirochete B. burgdorferi, is implicated in pathogen persistence and was recently reported to be nonimmunogenic in humans. Here we show that serum samples from Lyme disease patients contain antibodies with exclusive specificity for nondenatured structural determinants of CRASP-1.
Item Description:Gesehen am 02.06.2021
Physical Description:Online Resource
ISSN:1098-5522
DOI:10.1128/IAI.01028-06

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