Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond
Thrombin is the protease involved in blood coagulation. Its deregulation can lead to hemostatic abnormalities, which range from subtle subclinical to serious life-threatening coagulopathies, i.e., during septicemia. Additionally, thrombin plays important roles in many (patho)physiological conditions...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 August 2013
|
| In: |
Journal of molecular medicine
Year: 2013, Volume: 91, Issue: 11, Pages: 1257-1271 |
| ISSN: | 1432-1440 |
| DOI: | 10.1007/s00109-013-1074-5 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00109-013-1074-5 Verlag, lizenzpflichtig, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825489/ |
| Author Notes: | Sven Danckwardt, Matthias W. Hentze, Andreas E. Kulozik |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1759865613 | ||
| 003 | DE-627 | ||
| 005 | 20230427063240.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210604s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00109-013-1074-5 |2 doi | |
| 035 | |a (DE-627)1759865613 | ||
| 035 | |a (DE-599)KXP1759865613 | ||
| 035 | |a (OCoLC)1341415316 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Danckwardt, Sven |d 1973- |e VerfasserIn |0 (DE-588)124141234 |0 (DE-627)706552083 |0 (DE-576)29403708X |4 aut | |
| 245 | 1 | 0 | |a Pathologies at the nexus of blood coagulation and inflammation |b thrombin in hemostasis, cancer, and beyond |c Sven Danckwardt, Matthias W. Hentze, Andreas E. Kulozik |
| 264 | 1 | |c 17 August 2013 | |
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.06.2021 | ||
| 520 | |a Thrombin is the protease involved in blood coagulation. Its deregulation can lead to hemostatic abnormalities, which range from subtle subclinical to serious life-threatening coagulopathies, i.e., during septicemia. Additionally, thrombin plays important roles in many (patho)physiological conditions that reach far beyond its well-established role in stemming blood loss and thrombosis, including embryonic development and angiogenesis but also extending to inflammatory processes, complement activation, and even tumor biology. In this review, we will address thrombin’s broad roles in diverse (patho)physiological processes in an integrative way. We will also discuss thrombin as an emerging major target for novel therapies. | ||
| 700 | 1 | |a Hentze, Matthias W. |d 1960- |e VerfasserIn |0 (DE-588)143450395 |0 (DE-627)646106775 |0 (DE-576)337135754 |4 aut | |
| 700 | 1 | |a Kulozik, Andreas |d 1959- |e VerfasserIn |0 (DE-588)1025736567 |0 (DE-627)723892032 |0 (DE-576)167091638 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of molecular medicine |d Berlin : Springer, 1995 |g 91(2013), 11, Seite 1257-1271 |h Online-Ressource |w (DE-627)254630804 |w (DE-600)1462132-0 |w (DE-576)079420028 |x 1432-1440 |7 nnas |a Pathologies at the nexus of blood coagulation and inflammation thrombin in hemostasis, cancer, and beyond |
| 773 | 1 | 8 | |g volume:91 |g year:2013 |g number:11 |g pages:1257-1271 |g extent:15 |a Pathologies at the nexus of blood coagulation and inflammation thrombin in hemostasis, cancer, and beyond |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00109-013-1074-5 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825489/ |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210604 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 1025736567 |a Kulozik, Andreas |m 1025736567:Kulozik, Andreas |d 910000 |d 910500 |e 910000PK1025736567 |e 910500PK1025736567 |k 0/910000/ |k 1/910000/910500/ |p 3 |y j | ||
| 998 | |g 143450395 |a Hentze, Matthias W. |m 143450395:Hentze, Matthias W. |d 50000 |e 50000PH143450395 |k 0/50000/ |p 2 | ||
| 998 | |g 124141234 |a Danckwardt, Sven |m 124141234:Danckwardt, Sven |d 910000 |d 910500 |e 910000PD124141234 |e 910500PD124141234 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1759865613 |e 3934744311 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1007/s00109-013-1074-5"],"eki":["1759865613"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"17 August 2013"}],"name":{"displayForm":["Sven Danckwardt, Matthias W. Hentze, Andreas E. Kulozik"]},"recId":"1759865613","person":[{"role":"aut","given":"Sven","family":"Danckwardt","display":"Danckwardt, Sven"},{"display":"Hentze, Matthias W.","given":"Matthias W.","role":"aut","family":"Hentze"},{"role":"aut","given":"Andreas","family":"Kulozik","display":"Kulozik, Andreas"}],"title":[{"title_sort":"Pathologies at the nexus of blood coagulation and inflammation","subtitle":"thrombin in hemostasis, cancer, and beyond","title":"Pathologies at the nexus of blood coagulation and inflammation"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"physDesc":[{"extent":"15 S."}],"language":["eng"],"relHost":[{"pubHistory":["Volume 73, issue 1 (January 1995)-"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 14.03.25"],"title":[{"title_sort":"Journal of molecular medicine","title":"Journal of molecular medicine"}],"disp":"Pathologies at the nexus of blood coagulation and inflammation thrombin in hemostasis, cancer, and beyondJournal of molecular medicine","recId":"254630804","part":{"year":"2013","issue":"11","extent":"15","text":"91(2013), 11, Seite 1257-1271","pages":"1257-1271","volume":"91"},"id":{"eki":["254630804"],"zdb":["1462132-0"],"issn":["1432-1440"]},"origin":[{"publisherPlace":"Berlin ; Heidelberg ; New York, NY","dateIssuedKey":"1995","publisher":"Springer","dateIssuedDisp":"1995-"}]}],"note":["Gesehen am 04.06.2021"]} | ||
| SRT | |a DANCKWARDTPATHOLOGIE1720 | ||