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Specialized regulatory T cells control venous blood clot resolution through SPARC

The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describ...

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Main Authors: Shahneh, Fatemeh Zare (Author) , Grill, Alexandra (Author) , Klein, Matthias (Author) , Frauhammer, Felix (Author) , Bopp, Tobias (Author) , Schäfer, Katrin (Author) , Raker, Verena (Author) , Becker, Christian (Author)
Format: Article (Journal)
Language:English
Published: March 18, 2021
In: Blood
Year: 2021, Volume: 137, Issue: 11, Pages: 1517-1526
ISSN:1528-0020
DOI:10.1182/blood.2020005407
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1182/blood.2020005407
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Author Notes:Fatemeh Shahneh, Alexandra Grill, Matthias Klein, Felix Frauhammer, Tobias Bopp, Katrin Schäfer, Verena K. Raker, Christian Becker

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520 |a The cells and mechanisms involved in blood clot resorption are only partially known. We show that regulatory T cells (Tregs) accumulate in venous blood clots and regulate thrombolysis by controlling the recruitment, differentiation and matrix metalloproteinase (MMP) activity of monocytes. We describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein SPARC (secreted protein acidic and rich in cysteine) and show that SPARC enhances monocyte MMP activity and that SPARC+ Tregs are crucial for blood clot resorption. By comparing different treatment times, we define a therapeutic window of Treg expansion that accelerates clot resorption. 
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