Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity
Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates. Here we identify for the first time a multifunctional surface lipoprotein of...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 24, 2009
|
| In: |
PLOS ONE
Year: 2009, Volume: 4, Issue: 3, Pages: 1-12 |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0004858 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://dx.doi.org/10.1371/journal.pone.0004858 Verlag, lizenzpflichtig, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004858 
|
| Author Notes: | Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J. Cutler, Peter Kraiczy, Peter F. Zipfel, Markus M. Simon, Reinhard Wallich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1759903523 | ||
| 003 | DE-627 | ||
| 005 | 20241231004043.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210607s2009 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1371/journal.pone.0004858 |2 doi | |
| 035 | |a (DE-627)1759903523 | ||
| 035 | |a (DE-599)KXP1759903523 | ||
| 035 | |a (OCoLC)1341415216 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Grosskinsky, Sonja |e VerfasserIn |0 (DE-588)141204125 |0 (DE-627)703910566 |0 (DE-576)32273374X |4 aut | |
| 245 | 1 | 0 | |a Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity |c Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J. Cutler, Peter Kraiczy, Peter F. Zipfel, Markus M. Simon, Reinhard Wallich |
| 264 | 1 | |c March 24, 2009 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.06.2021 | ||
| 520 | |a Borrelia recurrentis, the etiologic agent of louse-borne relapsing fever in humans, has evolved strategies, including antigenic variation, to evade immune defence, thereby causing severe diseases with high mortality rates. Here we identify for the first time a multifunctional surface lipoprotein of B. recurrentis, termed HcpA, and demonstrate that it binds human complement regulators, Factor H, CFHR-1, and simultaneously, the host protease plasminogen. Cell surface bound factor H was found to retain its activity and to confer resistance to complement attack. Moreover, ectopic expression of HcpA in a B. burgdorferi B313 strain, deficient in Factor H binding proteins, protected the transformed spirochetes from complement-mediated killing. Furthermore, HcpA-bound plasminogen/plasmin endows B. recurrentis with the potential to resist opsonization and to degrade extracellular matrix components. Together, the present study underscores the high virulence potential of B. recurrentis. The elucidation of the molecular basis underlying the versatile strategies of B. recurrentis to escape innate immunity and to persist in human tissues, including the brain, may help to understand the pathological processes underlying louse-borne relapsing fever. | ||
| 650 | 4 | |a Bacterial Proteins | |
| 650 | 4 | |a Borrelia | |
| 650 | 4 | |a Complement C3b Inactivator Proteins | |
| 650 | 4 | |a Complement Factor H | |
| 650 | 4 | |a Complement System Proteins | |
| 650 | 4 | |a Extracellular Matrix | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunity, Innate | |
| 650 | 4 | |a Opsonin Proteins | |
| 650 | 4 | |a Plasminogen | |
| 650 | 4 | |a Protein Binding | |
| 700 | 1 | |a Schott, Melanie |d 1978- |e VerfasserIn |0 (DE-588)140767436 |0 (DE-627)621598747 |0 (DE-576)320691926 |4 aut | |
| 700 | 1 | |a Brenner, Christiane |e VerfasserIn |0 (DE-588)1161611304 |0 (DE-627)1024894479 |0 (DE-576)506757242 |4 aut | |
| 700 | 1 | |a Cutler, Sally J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kraiczy, Peter |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Zipfel, Peter F. |d 1954- |e VerfasserIn |0 (DE-588)110935810 |0 (DE-627)691099006 |0 (DE-576)289687810 |4 aut | |
| 700 | 1 | |a Simon, Markus M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wallich, Reinhard |e VerfasserIn |0 (DE-588)1059566710 |0 (DE-627)798640839 |0 (DE-576)163467781 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t PLOS ONE |d San Francisco, California, US : PLOS, 2006 |g 4(2009), 3, Artikel-ID e4858, Seite 1-12 |h Online-Ressource |w (DE-627)523574592 |w (DE-600)2267670-3 |w (DE-576)281331979 |x 1932-6203 |7 nnas |a Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity |
| 773 | 1 | 8 | |g volume:4 |g year:2009 |g number:3 |g elocationid:e4858 |g pages:1-12 |g extent:12 |a Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1371/journal.pone.0004858 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004858 |x Verlag |z lizenzpflichtig |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20241001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20210607 | ||
| 993 | |a Article | ||
| 994 | |a 2009 | ||
| 998 | |g 1059566710 |a Wallich, Reinhard |m 1059566710:Wallich, Reinhard |d 910000 |d 911600 |e 910000PW1059566710 |e 911600PW1059566710 |k 0/910000/ |k 1/910000/911600/ |p 8 |y j | ||
| 998 | |g 1161611304 |a Brenner, Christiane |m 1161611304:Brenner, Christiane |d 910000 |d 911600 |e 910000PB1161611304 |e 911600PB1161611304 |k 0/910000/ |k 1/910000/911600/ |p 3 | ||
| 998 | |g 140767436 |a Schott, Melanie |m 140767436:Schott, Melanie |d 910000 |d 911600 |e 910000PS140767436 |e 911600PS140767436 |k 0/910000/ |k 1/910000/911600/ |p 2 | ||
| 998 | |g 141204125 |a Grosskinsky, Sonja |m 141204125:Grosskinsky, Sonja |d 910000 |d 911600 |e 910000PG141204125 |e 911600PG141204125 |k 0/910000/ |k 1/910000/911600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1759903523 |e 3935060467 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title_sort":"Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity","title":"Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunity"}],"person":[{"display":"Grosskinsky, Sonja","roleDisplay":"VerfasserIn","role":"aut","family":"Grosskinsky","given":"Sonja"},{"roleDisplay":"VerfasserIn","display":"Schott, Melanie","role":"aut","family":"Schott","given":"Melanie"},{"given":"Christiane","family":"Brenner","role":"aut","display":"Brenner, Christiane","roleDisplay":"VerfasserIn"},{"given":"Sally J.","family":"Cutler","role":"aut","display":"Cutler, Sally J.","roleDisplay":"VerfasserIn"},{"given":"Peter","family":"Kraiczy","role":"aut","display":"Kraiczy, Peter","roleDisplay":"VerfasserIn"},{"family":"Zipfel","given":"Peter F.","roleDisplay":"VerfasserIn","display":"Zipfel, Peter F.","role":"aut"},{"display":"Simon, Markus M.","roleDisplay":"VerfasserIn","role":"aut","family":"Simon","given":"Markus M."},{"roleDisplay":"VerfasserIn","display":"Wallich, Reinhard","role":"aut","family":"Wallich","given":"Reinhard"}],"language":["eng"],"recId":"1759903523","note":["Gesehen am 07.06.2021"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.1371/journal.pone.0004858"],"eki":["1759903523"]},"origin":[{"dateIssuedKey":"2009","dateIssuedDisp":"March 24, 2009"}],"name":{"displayForm":["Sonja Grosskinsky, Melanie Schott, Christiane Brenner, Sally J. Cutler, Peter Kraiczy, Peter F. Zipfel, Markus M. Simon, Reinhard Wallich"]},"relHost":[{"title":[{"title":"PLOS ONE","title_sort":"PLOS ONE"}],"part":{"issue":"3","pages":"1-12","year":"2009","extent":"12","volume":"4","text":"4(2009), 3, Artikel-ID e4858, Seite 1-12"},"pubHistory":["1.2006 -"],"recId":"523574592","corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Public Library of Science","role":"isb"}],"language":["eng"],"disp":"Borrelia recurrentis employs a novel multifunctional surface protein with anti-complement, anti-opsonic and invasive potential to escape innate immunityPLOS ONE","note":["Schreibweise des Titels bis 2012: PLoS ONE","Gesehen am 20.03.19"],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"zdb":["2267670-3"],"eki":["523574592"],"issn":["1932-6203"]},"origin":[{"dateIssuedKey":"2006","publisher":"PLOS ; PLoS","dateIssuedDisp":"2006-","publisherPlace":"San Francisco, California, US ; Lawrence, Kan."}],"name":{"displayForm":["Public Library of Science"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"12 S."}]} | ||
| SRT | |a GROSSKINSKBORRELIARE2420 | ||