Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi
The complement regulator-acquiring surface protein (CRASP)-1 is a member of the paralogous gene family gbb54 and the dominant FHL-1 and factor H binding protein of Borrelia burgdorferi sensu stricto (s.s.). It was shown recently that expression of BbCRASP-1 directly correlates with serum resistance...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2006
|
| In: |
Wiener klinische Wochenschrift
Year: 2006, Volume: 118, Issue: 21/22, Pages: 669-676 |
| ISSN: | 1613-7671 |
| DOI: | 10.1007/s00508-006-0691-1 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00508-006-0691-1
|
| Author Notes: | Peter Kraiczy, Evelyn Rossmann, Volker Brade, Markus M. Simon, Christine Skerka, Peter F. Zipfel & Reinhard Wallich |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1759908959 | ||
| 003 | DE-627 | ||
| 005 | 20230427063245.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210607s2006 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00508-006-0691-1 |2 doi | |
| 035 | |a (DE-627)1759908959 | ||
| 035 | |a (DE-599)KXP1759908959 | ||
| 035 | |a (OCoLC)1341415372 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kraiczy, Peter |e VerfasserIn |0 (DE-588)1153855461 |0 (DE-627)1015413765 |0 (DE-576)500613168 |4 aut | |
| 245 | 1 | 0 | |a Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi |c Peter Kraiczy, Evelyn Rossmann, Volker Brade, Markus M. Simon, Christine Skerka, Peter F. Zipfel & Reinhard Wallich |
| 264 | 1 | |c November 2006 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.06.2021 | ||
| 520 | |a The complement regulator-acquiring surface protein (CRASP)-1 is a member of the paralogous gene family gbb54 and the dominant FHL-1 and factor H binding protein of Borrelia burgdorferi sensu stricto (s.s.). It was shown recently that expression of BbCRASP-1 directly correlates with serum resistance of B. burgdorferi s.s. isolates. In the present study we have elucidated the putative potential of other members of the gbb54 paralogous family, including orthologs ZSA66, ZSA69, ZSA70, ZSA71, ZSA72 and ZSA73 of the European B. burgdorferi s.s. strain ZS7, to bind human FHL-1 and factor H. In spite of their overall similarity in protein sequence, between 47% and 67%, and the fact that the C-terminal region of ZSA69 shows 70% similarity with BbCRASP-1, none of the orthologous proteins was able to bind human FHL-1 and/or factor H. BbCRASP-1 is the only member of the paralogous gene family gbb54 that binds to human complement regulators, supporting the notion that BbCRASP-1 plays a critical role in evasion of complement by B. burgdorferi s.s. and thus may be helpful in the development of novel therapeutic strategies against Lyme borreliosis. | ||
| 650 | 4 | |a Bacterial Proteins | |
| 650 | 4 | |a Base Sequence | |
| 650 | 4 | |a Blood Donors | |
| 650 | 4 | |a Borrelia burgdorferi | |
| 650 | 4 | |a Complement Activation | |
| 650 | 4 | |a Complement C3b Inactivator Proteins | |
| 650 | 4 | |a Complement Factor H | |
| 650 | 4 | |a DNA, Bacterial | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Immunity, Innate | |
| 650 | 4 | |a Lyme Disease | |
| 650 | 4 | |a Membrane Proteins | |
| 650 | 4 | |a Reverse Transcriptase Polymerase Chain Reaction | |
| 700 | 1 | |a Rossmann, Evelyn |e VerfasserIn |0 (DE-588)133382559 |0 (DE-627)544038347 |0 (DE-576)299810062 |4 aut | |
| 700 | 1 | |a Brade, Volker |e VerfasserIn |4 aut | |
| 700 | 1 | |a Simon, Markus M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Skerka, Christine |e VerfasserIn |0 (DE-588)1216431868 |0 (DE-627)1727665090 |0 (DE-576)502821655 |4 aut | |
| 700 | 1 | |a Zipfel, Peter F. |d 1954- |e VerfasserIn |0 (DE-588)110935810 |0 (DE-627)691099006 |0 (DE-576)289687810 |4 aut | |
| 700 | 1 | |a Wallich, Reinhard |e VerfasserIn |0 (DE-588)1059566710 |0 (DE-627)798640839 |0 (DE-576)163467781 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Wiener klinische Wochenschrift |d Wien : Springer, 2003 |g 118(2006), 21/22, Seite 669-676 |h Online-Ressource |w (DE-627)515976636 |w (DE-600)2244243-1 |w (DE-576)255885059 |x 1613-7671 |7 nnas |a Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi |
| 773 | 1 | 8 | |g volume:118 |g year:2006 |g number:21/22 |g pages:669-676 |g extent:8 |a Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00508-006-0691-1 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210607 | ||
| 993 | |a Article | ||
| 994 | |a 2006 | ||
| 998 | |g 1059566710 |a Wallich, Reinhard |m 1059566710:Wallich, Reinhard |d 910000 |d 911600 |e 910000PW1059566710 |e 911600PW1059566710 |k 0/910000/ |k 1/910000/911600/ |p 7 |y j | ||
| 998 | |g 133382559 |a Rossmann, Evelyn |m 133382559:Rossmann, Evelyn |d 910000 |d 911600 |e 910000PR133382559 |e 911600PR133382559 |k 0/910000/ |k 1/910000/911600/ |p 2 | ||
| 999 | |a KXP-PPN1759908959 |e 3935113447 | ||
| BIB | |a Y | ||
| SER | |a newspaper | ||
| JSO | |a {"relHost":[{"title":[{"title":"Wiener klinische Wochenschrift","subtitle":"middle european journal of medicine","title_sort":"Wiener klinische Wochenschrift"}],"type":{"media":"Online-Ressource","bibl":"newspaper"},"disp":"Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferiWiener klinische Wochenschrift","note":["Gesehen am 27.02.13"],"language":["ger","eng"],"corporate":[{"roleDisplay":"Herausgebendes Organ","display":"Gesellschaft der Ärzte in Wien","role":"isb"}],"recId":"515976636","pubHistory":["Nachgewiesen 115.2003 -"],"titleAlt":[{"title":"Middle european journal of medicine"}],"part":{"text":"118(2006), 21/22, Seite 669-676","volume":"118","extent":"8","year":"2006","pages":"669-676","issue":"21/22"},"origin":[{"publisherPlace":"Wien","dateIssuedDisp":"2003-","publisher":"Springer","dateIssuedKey":"2003"}],"id":{"issn":["1613-7671"],"eki":["515976636"],"zdb":["2244243-1"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"8 S."}],"name":{"displayForm":["Peter Kraiczy, Evelyn Rossmann, Volker Brade, Markus M. Simon, Christine Skerka, Peter F. Zipfel & Reinhard Wallich"]},"id":{"doi":["10.1007/s00508-006-0691-1"],"eki":["1759908959"]},"origin":[{"dateIssuedDisp":"November 2006","dateIssuedKey":"2006"}],"language":["eng"],"recId":"1759908959","type":{"media":"Online-Ressource","bibl":"article-newspaper"},"note":["Gesehen am 07.06.2021"],"person":[{"given":"Peter","family":"Kraiczy","role":"aut","roleDisplay":"VerfasserIn","display":"Kraiczy, Peter"},{"roleDisplay":"VerfasserIn","display":"Rossmann, Evelyn","role":"aut","family":"Rossmann","given":"Evelyn"},{"family":"Brade","given":"Volker","roleDisplay":"VerfasserIn","display":"Brade, Volker","role":"aut"},{"given":"Markus M.","family":"Simon","role":"aut","display":"Simon, Markus M.","roleDisplay":"VerfasserIn"},{"family":"Skerka","given":"Christine","roleDisplay":"VerfasserIn","display":"Skerka, Christine","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Zipfel, Peter F.","given":"Peter F.","family":"Zipfel"},{"roleDisplay":"VerfasserIn","display":"Wallich, Reinhard","role":"aut","family":"Wallich","given":"Reinhard"}],"title":[{"title":"Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi","title_sort":"Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi"}]} | ||
| SRT | |a KRAICZYPETBINDINGOFH2006 | ||