Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors
Multiple myeloma (MM) is still a fatal plasma cell cancer. Novel compounds are currently clinically tested as a single agent in relapsing patients, but in best cases with partial response of a fraction of patients, emphasising the need to design tools predicting drug efficacy. Histone deacetylase in...
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| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 July 2013
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| In: |
British journal of cancer
Year: 2013, Volume: 109, Issue: 3, Pages: 676-685 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/bjc.2013.392 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/bjc.2013.392 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/bjc2013392 |
| Author Notes: | J. Moreaux, T. Reme, W. Leonard, J.-L. Veyrune, G. Requirand, H. Goldschmidt, D. Hose and B. Klein |
MARC
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| 520 | |a Multiple myeloma (MM) is still a fatal plasma cell cancer. Novel compounds are currently clinically tested as a single agent in relapsing patients, but in best cases with partial response of a fraction of patients, emphasising the need to design tools predicting drug efficacy. Histone deacetylase inhibitors (HDACi) are anticancer agents targeting epigenetic regulation of gene expression and are in clinical development in MM. | ||
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