Cover Image

Can bottom-up synthetic biology generate advanced drug-delivery systems?

Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which relies on the use of nanotechnologies to fight disease, was envisaged to fulfill this coveted goal. Despite substantial...

Full description

Saved in:
Bibliographic Details
Main Authors: Lussier, Félix (Author) , Staufer, Oskar (Author) , Platzman, Ilia (Author) , Spatz, Joachim P. (Author)
Format: Article (Journal)
Language:English
Published: 2021
In: Trends in biotechnology
Year: 2021, Volume: 39, Issue: 5, Pages: 445-459
ISSN:1879-3096
DOI:10.1016/j.tibtech.2020.08.002
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tibtech.2020.08.002
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0167779920302109
Get full text
Author Notes:Felix Lussier, Oskar Staufer, Ilia Platzman, and Joachim P. Spatz

MARC

LEADER 00000caa a2200000 c 4500
001 1760100447
003 DE-627
005 20230427063254.0
007 cr uuu---uuuuu
008 210609s2021 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.tibtech.2020.08.002  |2 doi 
035 |a (DE-627)1760100447 
035 |a (DE-599)KXP1760100447 
035 |a (OCoLC)1341415498 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 30  |2 sdnb 
100 1 |a Lussier, Félix  |e VerfasserIn  |0 (DE-588)1190301237  |0 (DE-627)1668996936  |4 aut 
245 1 0 |a Can bottom-up synthetic biology generate advanced drug-delivery systems?  |c Felix Lussier, Oskar Staufer, Ilia Platzman, and Joachim P. Spatz 
264 1 |c 2021 
300 |a 15 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online 7 September 2020 
500 |a Gesehen am 09.06.2021 
520 |a Creating a magic bullet that can selectively kill cancer cells while sparing nearby healthy cells remains one of the most ambitious objectives in pharmacology. Nanomedicine, which relies on the use of nanotechnologies to fight disease, was envisaged to fulfill this coveted goal. Despite substantial progress, the structural complexity of therapeutic vehicles impedes their broad clinical application. Novel modular manufacturing approaches for engineering programmable drug carriers may be able to overcome some fundamental limitations of nanomedicine. We discuss how bottom-up synthetic biology principles, empowered by microfluidics, can palliate current drug carrier assembly limitations, and we demonstrate how such a magic bullet could be engineered from the bottom up to ultimately improve clinical outcomes for patients. 
650 4 |a bottom-up synthetic biology 
650 4 |a droplet-based microfluidics 
650 4 |a drug delivery 
700 1 |a Staufer, Oskar  |d 1990-  |e VerfasserIn  |0 (DE-588)1163402656  |0 (DE-627)1027769144  |0 (DE-576)507963555  |4 aut 
700 1 |a Platzman, Ilia  |e VerfasserIn  |0 (DE-588)1166793680  |0 (DE-627)1030663440  |0 (DE-576)510898327  |4 aut 
700 1 |a Spatz, Joachim P.  |d 1969-  |e VerfasserIn  |0 (DE-588)122582675  |0 (DE-627)08203124X  |0 (DE-576)173014771  |4 aut 
773 0 8 |i Enthalten in  |t Trends in biotechnology  |d Amsterdam [u.a.] : Elsevier Science, 1983  |g 39(2021), 5, Seite 445-459  |h Online-Ressource  |w (DE-627)320490866  |w (DE-600)2011002-9  |w (DE-576)116722657  |x 1879-3096  |7 nnas  |a Can bottom-up synthetic biology generate advanced drug-delivery systems? 
773 1 8 |g volume:39  |g year:2021  |g number:5  |g pages:445-459  |g extent:15  |a Can bottom-up synthetic biology generate advanced drug-delivery systems? 
856 4 0 |u https://doi.org/10.1016/j.tibtech.2020.08.002  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0167779920302109  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20210609 
993 |a Article 
994 |a 2021 
998 |g 122582675  |a Spatz, Joachim P.  |m 122582675:Spatz, Joachim P.  |d 120000  |d 120300  |e 120000PS122582675  |e 120300PS122582675  |k 0/120000/  |k 1/120000/120300/  |p 4  |y j 
998 |g 1166793680  |a Platzman, Ilia  |m 1166793680:Platzman, Ilia  |p 3 
998 |g 1163402656  |a Staufer, Oskar  |m 1163402656:Staufer, Oskar  |p 2 
998 |g 1190301237  |a Lussier, Felix  |m 1190301237:Lussier, Felix 
999 |a KXP-PPN1760100447  |e 3936233160 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"2021"}],"physDesc":[{"extent":"15 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"39","extent":"15","text":"39(2021), 5, Seite 445-459","issue":"5","year":"2021","pages":"445-459"},"note":["Gesehen am 28.05.20"],"type":{"bibl":"periodical","media":"Online-Ressource"},"title":[{"title":"Trends in biotechnology","title_sort":"Trends in biotechnology"}],"language":["eng"],"disp":"Can bottom-up synthetic biology generate advanced drug-delivery systems?Trends in biotechnology","recId":"320490866","id":{"issn":["1879-3096"],"zdb":["2011002-9"],"eki":["320490866"]},"pubHistory":["1.1983 -"],"origin":[{"dateIssuedDisp":"1983-","publisher":"Elsevier Science","publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1983"}]}],"note":["Online 7 September 2020","Gesehen am 09.06.2021"],"language":["eng"],"recId":"1760100447","id":{"eki":["1760100447"],"doi":["10.1016/j.tibtech.2020.08.002"]},"name":{"displayForm":["Felix Lussier, Oskar Staufer, Ilia Platzman, and Joachim P. Spatz"]},"person":[{"role":"aut","roleDisplay":"VerfasserIn","given":"Félix","display":"Lussier, Félix","family":"Lussier"},{"role":"aut","given":"Oskar","roleDisplay":"VerfasserIn","display":"Staufer, Oskar","family":"Staufer"},{"family":"Platzman","roleDisplay":"VerfasserIn","given":"Ilia","display":"Platzman, Ilia","role":"aut"},{"family":"Spatz","display":"Spatz, Joachim P.","roleDisplay":"VerfasserIn","given":"Joachim P.","role":"aut"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Can bottom-up synthetic biology generate advanced drug-delivery systems?","title":"Can bottom-up synthetic biology generate advanced drug-delivery systems?"}]} 
SRT |a LUSSIERFELCANBOTTOMU2021 

Similar Items