Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapy
MicroRNAs (miRs) are non-coding master regulators of transcriptome that could act as tumor suppressors (TSs) or oncogenes (oncomiRs). We aimed to systematically investigate the relevance of miRs as prognostic biomarkers in primary glioblastoma multiforme (GBM) treated with postoperative radio(chemo)...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 March 2021
|
| In: |
International journal of molecular sciences
Year: 2021, Jahrgang: 22, Heft: 6, Pages: 1-18 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22062960 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms22062960 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/22/6/2960 
|
| Verfasserangaben: | Elena Schnabel, Maximilian Knoll, Christian Schwager, Rolf Warta, Andreas Mock, Benito Campos, Laila König, Christine Jungk, Wolfgang Wick, Andreas Unterberg, Jürgen Debus, Christel Herold-Mende and Amir Abdollahi |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1760118591 | ||
| 003 | DE-627 | ||
| 005 | 20220819224144.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210609s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/ijms22062960 |2 doi | |
| 035 | |a (DE-627)1760118591 | ||
| 035 | |a (DE-599)KXP1760118591 | ||
| 035 | |a (OCoLC)1341415416 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schnabel-Besson, Elena |d 1990- |e VerfasserIn |0 (DE-588)1222196808 |0 (DE-627)1741198224 |4 aut | |
| 245 | 1 | 0 | |a Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapy |c Elena Schnabel, Maximilian Knoll, Christian Schwager, Rolf Warta, Andreas Mock, Benito Campos, Laila König, Christine Jungk, Wolfgang Wick, Andreas Unterberg, Jürgen Debus, Christel Herold-Mende and Amir Abdollahi |
| 264 | 1 | |c 15 March 2021 | |
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 09.06.2021 | ||
| 520 | |a MicroRNAs (miRs) are non-coding master regulators of transcriptome that could act as tumor suppressors (TSs) or oncogenes (oncomiRs). We aimed to systematically investigate the relevance of miRs as prognostic biomarkers in primary glioblastoma multiforme (GBM) treated with postoperative radio(chemo)therapy (PORT). For hypothesis generation, tumor miR expression by Agilent 8x15K human microRNA microarrays and survival data from 482 GBM patients of The Cancer Genome Atlas (TCGA cohort) were analyzed using Cox-PH models. Expression of candidate miRs with prognostic relevance (miR-221/222; miR-17-5p, miR-18a, miR-19b) was validated by qRT-PCR using Taqman technology on an independent validation cohort of GBM patients (n = 109) treated at Heidelberg University Hospital (HD cohort). In TCGA, 50 miRs showed significant association with survival. Among the top ranked prognostic miRs were members of the two miR families miR-221/222 and miR-17-92. Loss of miR-221/222 was correlated with improved prognosis in both cohorts (TCGA, HD) and was an independent prognostic marker in a multivariate analysis considering demographic characteristics (age, sex, Karnofsky performance index (KPI)), molecular markers (O-6-methylguanine-DNA methyltransferase (MGMT) methylation, IDH mutation status) and PORT as co-variables. The prognostic value of miR-17-92 family members was ambiguous and in part contradictory by direct comparison of the two cohorts, thus warranting further validation in larger prospective trials. | ||
| 650 | 4 | |a glioblastoma | |
| 650 | 4 | |a microRNA | |
| 650 | 4 | |a miR-17-92 | |
| 650 | 4 | |a miR-221 | |
| 650 | 4 | |a miR-222 | |
| 650 | 4 | |a prognosis | |
| 650 | 4 | |a radiochemotherapy | |
| 700 | 1 | |a Knoll, Maximilian |d 1988- |e VerfasserIn |0 (DE-588)1140661949 |0 (DE-627)898631998 |0 (DE-576)493979417 |4 aut | |
| 700 | 1 | |a Schwager, Christian |e VerfasserIn |0 (DE-588)1156925916 |0 (DE-627)1019872837 |0 (DE-576)502507187 |4 aut | |
| 700 | 1 | |a Warta, Rolf |d 1980- |e VerfasserIn |0 (DE-588)1047472260 |0 (DE-627)778430839 |0 (DE-576)401088030 |4 aut | |
| 700 | 1 | |a Mock, Andreas |d 1989- |e VerfasserIn |0 (DE-588)1071913905 |0 (DE-627)826601995 |0 (DE-576)433423331 |4 aut | |
| 700 | 1 | |a Campos, Benito |d 1980- |e VerfasserIn |0 (DE-588)142071943 |0 (DE-627)704135280 |0 (DE-576)327466723 |4 aut | |
| 700 | 1 | |a König, Laila |d 1986- |e VerfasserIn |0 (DE-588)1053640579 |0 (DE-627)790403315 |0 (DE-576)409584282 |4 aut | |
| 700 | 1 | |a Jungk, Christine |e VerfasserIn |0 (DE-588)1051888247 |0 (DE-627)78696765X |0 (DE-576)407515968 |4 aut | |
| 700 | 1 | |a Wick, Wolfgang |d 1970- |e VerfasserIn |0 (DE-588)120297736 |0 (DE-627)080586929 |0 (DE-576)186221320 |4 aut | |
| 700 | 1 | |a Unterberg, Andreas |e VerfasserIn |0 (DE-588)1032681187 |0 (DE-627)738641200 |0 (DE-576)168441233 |4 aut | |
| 700 | 1 | |a Debus, Jürgen |d 1964- |e VerfasserIn |0 (DE-588)1022671421 |0 (DE-627)717025780 |0 (DE-576)365774944 |4 aut | |
| 700 | 1 | |a Herold-Mende, Christel |e VerfasserIn |0 (DE-588)1022936549 |0 (DE-627)717335577 |0 (DE-576)366194267 |4 aut | |
| 700 | 1 | |a Abdollahi, Amir |e VerfasserIn |0 (DE-588)129612715 |0 (DE-627)474757765 |0 (DE-576)297748874 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of molecular sciences |d Basel : Molecular Diversity Preservation International, 2000 |g 22(2021), 6, Artikel-ID 2960, Seite 1-18 |h Online-Ressource |w (DE-627)316340715 |w (DE-600)2019364-6 |w (DE-576)281194653 |x 1422-0067 |7 nnas |a Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapy |
| 773 | 1 | 8 | |g volume:22 |g year:2021 |g number:6 |g elocationid:2960 |g pages:1-18 |g extent:18 |a Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapy |
| 856 | 4 | 0 | |u https://doi.org/10.3390/ijms22062960 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/1422-0067/22/6/2960 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210609 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 129612715 |a Abdollahi, Amir |m 129612715:Abdollahi, Amir |d 910000 |d 911400 |e 910000PA129612715 |e 911400PA129612715 |k 0/910000/ |k 1/910000/911400/ |p 13 |y j | ||
| 998 | |g 1022936549 |a Herold-Mende, Christel |m 1022936549:Herold-Mende, Christel |d 910000 |d 911200 |e 910000PH1022936549 |e 911200PH1022936549 |k 0/910000/ |k 1/910000/911200/ |p 12 | ||
| 998 | |g 1022671421 |a Debus, Jürgen |m 1022671421:Debus, Jürgen |d 910000 |d 911400 |e 910000PD1022671421 |e 911400PD1022671421 |k 0/910000/ |k 1/910000/911400/ |p 11 | ||
| 998 | |g 1032681187 |a Unterberg, Andreas |m 1032681187:Unterberg, Andreas |d 910000 |d 911200 |e 910000PU1032681187 |e 911200PU1032681187 |k 0/910000/ |k 1/910000/911200/ |p 10 | ||
| 998 | |g 120297736 |a Wick, Wolfgang |m 120297736:Wick, Wolfgang |d 910000 |d 911100 |e 910000PW120297736 |e 911100PW120297736 |k 0/910000/ |k 1/910000/911100/ |p 9 | ||
| 998 | |g 1051888247 |a Jungk, Christine |m 1051888247:Jungk, Christine |d 910000 |d 911200 |d 50000 |e 910000PJ1051888247 |e 911200PJ1051888247 |e 50000PJ1051888247 |k 0/910000/ |k 1/910000/911200/ |k 0/50000/ |p 8 | ||
| 998 | |g 1053640579 |a König, Laila |m 1053640579:König, Laila |d 910000 |d 911400 |e 910000PK1053640579 |e 911400PK1053640579 |k 0/910000/ |k 1/910000/911400/ |p 7 | ||
| 998 | |g 142071943 |a Campos, Benito |m 142071943:Campos, Benito |d 50000 |e 50000PC142071943 |k 0/50000/ |p 6 | ||
| 998 | |g 1071913905 |a Mock, Andreas |m 1071913905:Mock, Andreas |d 910000 |d 910100 |e 910000PM1071913905 |e 910100PM1071913905 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 1047472260 |a Warta, Rolf |m 1047472260:Warta, Rolf |d 910000 |d 911200 |e 910000PW1047472260 |e 911200PW1047472260 |k 0/910000/ |k 1/910000/911200/ |p 4 | ||
| 998 | |g 1156925916 |a Schwager, Christian |m 1156925916:Schwager, Christian |d 50000 |e 50000PS1156925916 |k 0/50000/ |p 3 | ||
| 998 | |g 1140661949 |a Knoll, Maximilian |m 1140661949:Knoll, Maximilian |d 910000 |d 911400 |e 910000PK1140661949 |e 911400PK1140661949 |k 0/910000/ |k 1/910000/911400/ |p 2 | ||
| 998 | |g 1222196808 |a Schnabel-Besson, Elena |m 1222196808:Schnabel-Besson, Elena |d 910000 |d 910500 |e 910000PS1222196808 |e 910500PS1222196808 |k 0/910000/ |k 1/910000/910500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1760118591 |e 3936303215 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"doi":["10.3390/ijms22062960"],"eki":["1760118591"]},"language":["eng"],"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"15 March 2021"}],"person":[{"given":"Elena","family":"Schnabel-Besson","display":"Schnabel-Besson, Elena","role":"aut"},{"family":"Knoll","display":"Knoll, Maximilian","given":"Maximilian","role":"aut"},{"role":"aut","family":"Schwager","display":"Schwager, Christian","given":"Christian"},{"display":"Warta, Rolf","family":"Warta","given":"Rolf","role":"aut"},{"family":"Mock","display":"Mock, Andreas","given":"Andreas","role":"aut"},{"role":"aut","display":"Campos, Benito","family":"Campos","given":"Benito"},{"family":"König","display":"König, Laila","given":"Laila","role":"aut"},{"role":"aut","family":"Jungk","display":"Jungk, Christine","given":"Christine"},{"given":"Wolfgang","family":"Wick","display":"Wick, Wolfgang","role":"aut"},{"given":"Andreas","family":"Unterberg","display":"Unterberg, Andreas","role":"aut"},{"given":"Jürgen","family":"Debus","display":"Debus, Jürgen","role":"aut"},{"family":"Herold-Mende","display":"Herold-Mende, Christel","given":"Christel","role":"aut"},{"family":"Abdollahi","display":"Abdollahi, Amir","given":"Amir","role":"aut"}],"title":[{"title":"Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapy","title_sort":"Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapy"}],"physDesc":[{"extent":"18 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"International journal of molecular sciences","title_sort":"International journal of molecular sciences"}],"titleAlt":[{"title":"IJMS"}],"part":{"pages":"1-18","text":"22(2021), 6, Artikel-ID 2960, Seite 1-18","volume":"22","issue":"6","year":"2021","extent":"18"},"origin":[{"dateIssuedKey":"2000","publisher":"Molecular Diversity Preservation International","dateIssuedDisp":"2000-","publisherPlace":"Basel"}],"language":["eng"],"id":{"issn":["1422-0067","1661-6596"],"zdb":["2019364-6"],"eki":["316340715"]},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 17.09.20"],"pubHistory":["1.2000 -"],"recId":"316340715","disp":"Prognostic value of microRNA-221/2 and 17-92 families in primary glioblastoma patients treated with postoperative radiotherapyInternational journal of molecular sciences"}],"name":{"displayForm":["Elena Schnabel, Maximilian Knoll, Christian Schwager, Rolf Warta, Andreas Mock, Benito Campos, Laila König, Christine Jungk, Wolfgang Wick, Andreas Unterberg, Jürgen Debus, Christel Herold-Mende and Amir Abdollahi"]},"note":["Gesehen am 09.06.2021"],"recId":"1760118591"} | ||
| SRT | |a SCHNABELBEPROGNOSTIC1520 | ||