Cover Image

Attrition of X chromosome inactivation in aged hematopoietic stem cells

During X chromosome inactivation (XCI), the inactive X chromosome (Xi) is recruited to the nuclear lamina at the nuclear periphery. Beside X chromosome reactivation resulting in a highly penetrant aging-like hematopoietic malignancy, little is known about XCI in aged hematopoietic stem cells (HSCs)....

Full description

Saved in:
Bibliographic Details
Main Authors: Grigoryan, Ani (Author) , Pospiech, Johannes (Author) , Krämer, Stephen (Author) , Lipka, Daniel (Author) , Liehr, Thomas (Author) , Geiger, Hartmut (Author) , Kimura, Hiroshi (Author) , Medhanie Assmelash Mulaw (Author) , Florian, Maria Carolina (Author)
Format: Article (Journal)
Language:English
Published: 13 April 2021
In: Stem cell reports
Year: 2021, Volume: 16, Issue: 4, Pages: 708-716
ISSN:2213-6711
DOI:10.1016/j.stemcr.2021.03.007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.stemcr.2021.03.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2213671121001375
Get full text
Author Notes:Ani Grigoryan, Johannes Pospiech, Stephen Krämer, Daniel Lipka, Thomas Liehr, Hartmut Geiger, Hiroshi Kimura, Medhanie A. Mulaw, and Maria Carolina Florian

MARC

LEADER 00000caa a2200000 c 4500
001 1760200182
003 DE-627
005 20240307093532.0
007 cr uuu---uuuuu
008 210610s2021 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.stemcr.2021.03.007  |2 doi 
035 |a (DE-627)1760200182 
035 |a (DE-599)KXP1760200182 
035 |a (OCoLC)1425218059 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Grigoryan, Ani  |e VerfasserIn  |0 (DE-588)1141591332  |0 (DE-627)1000474615  |0 (DE-576)494412763  |4 aut 
245 1 0 |a Attrition of X chromosome inactivation in aged hematopoietic stem cells  |c Ani Grigoryan, Johannes Pospiech, Stephen Krämer, Daniel Lipka, Thomas Liehr, Hartmut Geiger, Hiroshi Kimura, Medhanie A. Mulaw, and Maria Carolina Florian 
264 1 |c 13 April 2021 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
520 |a During X chromosome inactivation (XCI), the inactive X chromosome (Xi) is recruited to the nuclear lamina at the nuclear periphery. Beside X chromosome reactivation resulting in a highly penetrant aging-like hematopoietic malignancy, little is known about XCI in aged hematopoietic stem cells (HSCs). Here, we demonstrate that LaminA/C defines a distinct repressive nuclear compartment for XCI in young HSCs, and its reduction in aged HSCs correlates with an impairment in the overall control of XCI. Integrated omics analyses reveal higher variation in gene expression, global hypomethylation, and significantly increased chromatin accessibility on the X chromosome (Chr X) in aged HSCs. In summary, our data support the role of LaminA/C in the establishment of a special repressive compartment for XCI in HSCs, which is impaired upon aging. 
650 4 |a aging 
650 4 |a ATACseq 
650 4 |a chromatin accessibility 
650 4 |a chromatin architecture 
650 4 |a hematopoietic stem cell 
650 4 |a HSC 
650 4 |a LaminA/C 
650 4 |a scRNAseq 
650 4 |a X chromosome inactivation 
700 1 |a Pospiech, Johannes  |e VerfasserIn  |4 aut 
700 1 |a Krämer, Stephen  |d 1987-  |e VerfasserIn  |0 (DE-588)1259923193  |0 (DE-627)1807065456  |4 aut 
700 1 |a Lipka, Daniel  |d 1976-  |e VerfasserIn  |0 (DE-588)131915312  |0 (DE-627)516076426  |0 (DE-576)298833328  |4 aut 
700 1 |a Liehr, Thomas  |d 1965-  |e VerfasserIn  |0 (DE-588)115661239  |0 (DE-627)077390822  |0 (DE-576)17758680X  |4 aut 
700 1 |a Geiger, Hartmut  |e VerfasserIn  |4 aut 
700 1 |a Kimura, Hiroshi  |e VerfasserIn  |4 aut 
700 0 |a Medhanie Assmelash Mulaw  |d 1976-  |e VerfasserIn  |0 (DE-588)13922324X  |0 (DE-627)609047736  |0 (DE-576)310779669  |4 aut 
700 1 |a Florian, Maria Carolina  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Stem cell reports  |d Maryland Heights, MO : Cell Press, 2013  |g 16(2021), 4 vom: Apr., Seite 708-716  |h Online-Ressource  |w (DE-627)749730862  |w (DE-600)2720528-9  |w (DE-576)383773474  |x 2213-6711  |7 nnas  |a Attrition of X chromosome inactivation in aged hematopoietic stem cells 
773 1 8 |g volume:16  |g year:2021  |g number:4  |g month:04  |g pages:708-716  |g extent:9  |a Attrition of X chromosome inactivation in aged hematopoietic stem cells 
856 4 0 |u https://doi.org/10.1016/j.stemcr.2021.03.007  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S2213671121001375  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20240215 
993 |a Article 
994 |a 2021 
998 |g 131915312  |a Lipka, Daniel  |m 131915312:Lipka, Daniel  |d 140000  |e 140000PL131915312  |k 0/140000/  |p 4 
998 |g 1259923193  |a Krämer, Stephen  |m 1259923193:Krämer, Stephen  |d 140000  |e 140000PK1259923193  |k 0/140000/  |p 3 
999 |a KXP-PPN1760200182  |e 4485019063 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedKey":"2021","dateIssuedDisp":"13 April 2021"}],"id":{"doi":["10.1016/j.stemcr.2021.03.007"],"eki":["1760200182"]},"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.2013 -"],"language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 25.08.20"],"title":[{"title_sort":"Stem cell reports","title":"Stem cell reports"}],"disp":"Attrition of X chromosome inactivation in aged hematopoietic stem cellsStem cell reports","name":{"displayForm":["International Society for Stem Cell Research"]},"recId":"749730862","part":{"issue":"4","year":"2021","pages":"708-716","volume":"16","text":"16(2021), 4 vom: Apr., Seite 708-716","extent":"9"},"id":{"eki":["749730862"],"issn":["2213-6711"],"zdb":["2720528-9"]},"origin":[{"publisherPlace":"Maryland Heights, MO ; [New York, NY]","dateIssuedDisp":"2013-","dateIssuedKey":"2013","publisher":"Cell Press ; Elsevier"}]}],"recId":"1760200182","name":{"displayForm":["Ani Grigoryan, Johannes Pospiech, Stephen Krämer, Daniel Lipka, Thomas Liehr, Hartmut Geiger, Hiroshi Kimura, Medhanie A. Mulaw, and Maria Carolina Florian"]},"title":[{"title_sort":"Attrition of X chromosome inactivation in aged hematopoietic stem cells","title":"Attrition of X chromosome inactivation in aged hematopoietic stem cells"}],"person":[{"display":"Grigoryan, Ani","role":"aut","given":"Ani","family":"Grigoryan"},{"given":"Johannes","role":"aut","family":"Pospiech","display":"Pospiech, Johannes"},{"display":"Krämer, Stephen","family":"Krämer","given":"Stephen","role":"aut"},{"role":"aut","given":"Daniel","family":"Lipka","display":"Lipka, Daniel"},{"family":"Liehr","given":"Thomas","role":"aut","display":"Liehr, Thomas"},{"display":"Geiger, Hartmut","family":"Geiger","role":"aut","given":"Hartmut"},{"given":"Hiroshi","role":"aut","family":"Kimura","display":"Kimura, Hiroshi"},{"family":"Medhanie Assmelash Mulaw","role":"aut","given":"","display":"Medhanie Assmelash Mulaw"},{"display":"Florian, Maria Carolina","given":"Maria Carolina","role":"aut","family":"Florian"}],"physDesc":[{"extent":"9 S."}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"}} 
SRT |a GRIGORYANAATTRITIONO1320 

Similar Items