Emerging insights into the ependymoma epigenome
Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic pro...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 February 2013
|
| In: |
Brain pathology
Year: 2013, Jahrgang: 23, Heft: 2, Pages: 206-209 |
| ISSN: | 1750-3639 |
| DOI: | 10.1111/bpa.12020 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/bpa.12020 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12020 
|
| Verfasserangaben: | Stephen C. Mack, Hendrik Witt, Xin Wang, Till Milde, Yuan Yao, Kelsey C. Bertrand, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 176031725X | ||
| 003 | DE-627 | ||
| 005 | 20230428014357.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210611s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/bpa.12020 |2 doi | |
| 035 | |a (DE-627)176031725X | ||
| 035 | |a (DE-599)KXP176031725X | ||
| 035 | |a (OCoLC)1341416180 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mack, Stephen C. |e VerfasserIn |0 (DE-588)1150183934 |0 (DE-627)1010356992 |0 (DE-576)496936832 |4 aut | |
| 245 | 1 | 0 | |a Emerging insights into the ependymoma epigenome |c Stephen C. Mack, Hendrik Witt, Xin Wang, Till Milde, Yuan Yao, Kelsey C. Bertrand, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor |
| 264 | 1 | |c 25 February 2013 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.06.2021 | ||
| 520 | |a Ependymoma is the third most common pediatric brain tumor, yet because of the paucity of effective therapeutic interventions, 45% of patients remain incurable. Recent transcriptional and copy number profiling of the disease has identified few driver genes and in fact points to a balanced genomic profile. Candidate gene approaches looking at hypermethylated promoters and genome-wide epigenetic arrays suggest that DNA methylation may be critical to ependymoma pathogenesis. This review attempts to highlight existing and emerging evidence implicating the ependymoma epigenome as a key player and that epigenetic modifiers may offer new targeted therapeutic avenues for patients. | ||
| 650 | 4 | |a DNA methylation | |
| 650 | 4 | |a ependymoma | |
| 650 | 4 | |a epigenetic therapy | |
| 650 | 4 | |a epigenetics | |
| 700 | 1 | |a Witt, Hendrik |e VerfasserIn |0 (DE-588)1043235884 |0 (DE-627)770439373 |0 (DE-576)394592085 |4 aut | |
| 700 | 1 | |a Wang, Xin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Milde, Till |d 1973- |e VerfasserIn |0 (DE-588)1038311837 |0 (DE-627)75711234X |0 (DE-576)39229334X |4 aut | |
| 700 | 1 | |a Yao, Yuan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bertrand, Kelsey C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Korshunov, Andrey |e VerfasserIn |0 (DE-588)1043235361 |0 (DE-627)770439365 |0 (DE-576)394592093 |4 aut | |
| 700 | 1 | |a Pfister, Stefan |d 1974- |e VerfasserIn |0 (DE-588)123850215 |0 (DE-627)706450930 |0 (DE-576)293908400 |4 aut | |
| 700 | 1 | |a Taylor, Michael D. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Brain pathology |d Oxford : Wiley-Blackwell, 1990 |g 23(2013), 2 vom: März, Seite 206-209 |w (DE-627)324660677 |w (DE-600)2029927-8 |w (DE-576)098546325 |x 1750-3639 |7 nnas |a Emerging insights into the ependymoma epigenome |
| 773 | 1 | 8 | |g volume:23 |g year:2013 |g number:2 |g month:03 |g pages:206-209 |g extent:4 |a Emerging insights into the ependymoma epigenome |
| 856 | 4 | 0 | |u https://doi.org/10.1111/bpa.12020 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/bpa.12020 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20210611 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 123850215 |a Pfister, Stefan |m 123850215:Pfister, Stefan |d 50000 |e 50000PP123850215 |k 0/50000/ |p 8 | ||
| 998 | |g 1038311837 |a Milde, Till |m 1038311837:Milde, Till |d 910000 |d 910500 |e 910000PM1038311837 |e 910500PM1038311837 |k 0/910000/ |k 1/910000/910500/ |p 4 | ||
| 998 | |g 1043235884 |a Witt, Hendrik |m 1043235884:Witt, Hendrik |d 910000 |d 910500 |e 910000PW1043235884 |e 910500PW1043235884 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 999 | |a KXP-PPN176031725X |e 3936880182 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"language":["eng"],"pubHistory":["1.1990/91 -"],"note":["Gesehen am 23.09.2021"],"type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"324660677","id":{"zdb":["2029927-8"],"eki":["324660677"],"doi":["10.1111/(ISSN)1750-3639"],"issn":["1750-3639"]},"origin":[{"dateIssuedDisp":"1990-","publisherPlace":"Oxford ; [Erscheinungsort nicht ermittelbar] ; Oxford","dateIssuedKey":"1990","publisher":"Wiley-Blackwell ; International Society of Neuropathology ; Blackwell"}],"disp":"Emerging insights into the ependymoma epigenomeBrain pathology","title":[{"subtitle":"the official journal of the International Society of Neuropathology","title_sort":"Brain pathology","title":"Brain pathology"}],"part":{"year":"2013","pages":"206-209","issue":"2","extent":"4","text":"23(2013), 2 vom: März, Seite 206-209","volume":"23"}}],"physDesc":[{"extent":"4 S."}],"title":[{"title_sort":"Emerging insights into the ependymoma epigenome","title":"Emerging insights into the ependymoma epigenome"}],"id":{"doi":["10.1111/bpa.12020"],"eki":["176031725X"]},"recId":"176031725X","type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"25 February 2013"}],"name":{"displayForm":["Stephen C. Mack, Hendrik Witt, Xin Wang, Till Milde, Yuan Yao, Kelsey C. Bertrand, Andrey Korshunov, Stefan M. Pfister, Michael D. Taylor"]},"note":["Gesehen am 11.06.2021"],"language":["eng"],"person":[{"display":"Mack, Stephen C.","family":"Mack","role":"aut","given":"Stephen C."},{"given":"Hendrik","role":"aut","family":"Witt","display":"Witt, Hendrik"},{"display":"Wang, Xin","role":"aut","family":"Wang","given":"Xin"},{"display":"Milde, Till","family":"Milde","role":"aut","given":"Till"},{"family":"Yao","role":"aut","display":"Yao, Yuan","given":"Yuan"},{"given":"Kelsey C.","role":"aut","family":"Bertrand","display":"Bertrand, Kelsey C."},{"given":"Andrey","family":"Korshunov","role":"aut","display":"Korshunov, Andrey"},{"display":"Pfister, Stefan","family":"Pfister","role":"aut","given":"Stefan"},{"given":"Michael D.","family":"Taylor","role":"aut","display":"Taylor, Michael D."}]} | ||
| SRT | |a MACKSTEPHEEMERGINGIN2520 | ||