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Synthesis of Functionalized Pseudopeptides through Five-Component Sequential Ugi/Nucleophilic Reaction of N-Substituted 2-Alkynamides with Hydrazides

Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, primary amines, propiolic acid, isocyanides, and hydrazides has been developed in order to access polyfunctional pseudopeptides. The reaction may proceed through formation of N-substituted 2-alkynamides as intermedia...

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Main Authors: Maghari, Shokoofeh (Author) , Ramezanpour, Sorour (Author) , Balalaie, Saeed (Author) , Darvish, Fatemeh (Author) , Rominger, Frank (Author) , Bijanzadeh, Hamid Reza (Author)
Format: Article (Journal)
Language:English
Published: June 5, 2013
In: The journal of organic chemistry
Year: 2013, Volume: 78, Issue: 13, Pages: 6450-6456
ISSN:1520-6904
DOI:10.1021/jo4003294
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/jo4003294
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Author Notes:Shokoofeh Maghari, Sorour Ramezanpour, Saeed Balalaie, Fatemeh Darvish, Frank Rominger, Hamid Reza Bijanzadeh
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Summary:Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, primary amines, propiolic acid, isocyanides, and hydrazides has been developed in order to access polyfunctional pseudopeptides. The reaction may proceed through formation of N-substituted 2-alkynamides as intermediates. This process is found to be mild and operationally simple with broad substrate scope.
Item Description:Gesehen am 11.06.2021
Physical Description:Online Resource
ISSN:1520-6904
DOI:10.1021/jo4003294

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