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Synthesis of Functionalized Pseudopeptides through Five-Component Sequential Ugi/Nucleophilic Reaction of N-Substituted 2-Alkynamides with Hydrazides

Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, primary amines, propiolic acid, isocyanides, and hydrazides has been developed in order to access polyfunctional pseudopeptides. The reaction may proceed through formation of N-substituted 2-alkynamides as intermedia...

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Hauptverfasser: Maghari, Shokoofeh (VerfasserIn) , Ramezanpour, Sorour (VerfasserIn) , Balalaie, Saeed (VerfasserIn) , Darvish, Fatemeh (VerfasserIn) , Rominger, Frank (VerfasserIn) , Bijanzadeh, Hamid Reza (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 5, 2013
In: The journal of organic chemistry
Year: 2013, Jahrgang: 78, Heft: 13, Pages: 6450-6456
ISSN:1520-6904
DOI:10.1021/jo4003294
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/jo4003294
Volltext
Verfasserangaben:Shokoofeh Maghari, Sorour Ramezanpour, Saeed Balalaie, Fatemeh Darvish, Frank Rominger, Hamid Reza Bijanzadeh
Beschreibung
Zusammenfassung:Five-component sequential Ugi/nucleophilic addition reaction of aromatic aldehydes, primary amines, propiolic acid, isocyanides, and hydrazides has been developed in order to access polyfunctional pseudopeptides. The reaction may proceed through formation of N-substituted 2-alkynamides as intermediates. This process is found to be mild and operationally simple with broad substrate scope.
Beschreibung:Gesehen am 11.06.2021
Beschreibung:Online Resource
ISSN:1520-6904
DOI:10.1021/jo4003294

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