Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer
Background:Epidermal growth factor receptor-mutated (EGFR+) non-small-cell lung cancer (NSCLC) patients failing tyrosine kinase inhibitors (TKI) can benefit from next-line targeted therapies, but implementation is challenging.Methods:EGFR+ NSCLC patients treated with first/second-generation (1G/2G)...
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| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 24, 2021
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| In: |
Therapeutic advances in medical oncology
Year: 2021, Jahrgang: 13, Pages: 1-13 |
| ISSN: | 1758-8359 |
| DOI: | 10.1177/1758835921996509 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1177/1758835921996509
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| Verfasserangaben: | Nikolaus Magios, Farastuk Bozorgmehr, Anna-Lena Volckmar, Daniel Kazdal, Martina Kirchner, Felix J. Herth, Claus-Peter Heussel, Florian Eichhorn, Michael Meister, Thomas Muley, Rami A. Elshafie, Jürgen R. Fischer, Martin Faehling, Mark Kriegsmann, Peter Schirmacher, Helge Bischoff, Albrecht Stenzinger, Michael Thomas and Petros Christopoulos |
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| 245 | 1 | 0 | |a Real-world implementation of sequential targeted therapies for EGFR-mutated lung cancer |c Nikolaus Magios, Farastuk Bozorgmehr, Anna-Lena Volckmar, Daniel Kazdal, Martina Kirchner, Felix J. Herth, Claus-Peter Heussel, Florian Eichhorn, Michael Meister, Thomas Muley, Rami A. Elshafie, Jürgen R. Fischer, Martin Faehling, Mark Kriegsmann, Peter Schirmacher, Helge Bischoff, Albrecht Stenzinger, Michael Thomas and Petros Christopoulos |
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| 520 | |a Background:Epidermal growth factor receptor-mutated (EGFR+) non-small-cell lung cancer (NSCLC) patients failing tyrosine kinase inhibitors (TKI) can benefit from next-line targeted therapies, but implementation is challenging.Methods:EGFR+ NSCLC patients treated with first/second-generation (1G/2G) TKI at our institution with a last follow-up after osimertinib approval (February 2016), were analyzed retrospectively, and the results compared with published data under osimertinib.Results:A total of 207 patients received erlotinib (37%), gefitinib (16%) or afatinib (47%). The median age was 66?years, with a predominance of female (70%), never/light-smokers (69%). T790M testing was performed in 174/202 progressive cases (86%), positive in 93/174 (53%), and followed by osimertinib in 87/93 (94%). Among the 135 deceased patients, 94 (70%) received subsequent systemic treatment (43% chemotherapy, 39% osimertinib), while 30% died without, either before (4%) or after progression, due to rapid clinical deterioration (22%), patient refusal of further therapy (2%), or severe competing illness (2%). Lack of subsequent treatment was significantly (4.5x, p? | ||
| 650 | 4 | |a EGFR T790M mutation | |
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| 650 | 4 | |a overall survival | |
| 650 | 4 | |a rebiopsy | |
| 650 | 4 | |a second line | |
| 650 | 4 | |a tyrosine kinase inhibitor | |
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