Hot-spot KIF5A mutations cause familial ALS
Heterozygous missense mutations in the N-terminal motor or coiled-coil domains of the kinesin family member 5A (KIF5A) gene cause monogenic spastic paraplegia (HSP10) and Charcot-Marie-Tooth disease type 2 (CMT2). Moreover, heterozygous de novo frame-shift mutations in the C-terminal domain of KIF5A...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 January 2018
|
| In: |
Brain
Year: 2018, Jahrgang: 141, Heft: 3, Pages: 688-697 |
| ISSN: | 1460-2156 |
| Online-Zugang: |
|
| Verfasserangaben: | David Brenner, Rüstem Yilmaz, Kathrin Müller, Torsten Grehl, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Wolfgang Ruf, Christoph Neuwirth, Markus Weber, Susana Pinto, Kristl G. Claeys, Berthold Schrank, Berit Jordan, Antje Knehr, Kornelia Günther, Annemarie Hübers, Daniel Zeller, Christian Kubisch, Sibylle Jablonka, Michael Sendtner, Thomas Klopstock, Mamede de Carvalho, Anne Sperfeld, Guntram Borck, Alexander E. Volk, Johannes Dorst, Joachim Weis, Markus Otto, Joachim Schuster, Kelly Del Tredici, Heiko Braak, Karin M. Danzer, Axel Freischmidt, Thomas Meitinger, Tim M. Strom, Albert C. Ludolph, Peter M. Andersen and Jochen H. Weishaupt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1760576204 | ||
| 003 | DE-627 | ||
| 005 | 20250323030404.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 210616s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/brain/awx370 |2 doi | |
| 035 | |a (DE-627)1760576204 | ||
| 035 | |a (DE-599)KXP1760576204 | ||
| 035 | |a (OCoLC)1341416451 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Brenner, David |d 1986- |e VerfasserIn |0 (DE-588)1077188838 |0 (DE-627)836099753 |0 (DE-576)446029262 |4 aut | |
| 245 | 1 | 0 | |a Hot-spot KIF5A mutations cause familial ALS |c David Brenner, Rüstem Yilmaz, Kathrin Müller, Torsten Grehl, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Wolfgang Ruf, Christoph Neuwirth, Markus Weber, Susana Pinto, Kristl G. Claeys, Berthold Schrank, Berit Jordan, Antje Knehr, Kornelia Günther, Annemarie Hübers, Daniel Zeller, Christian Kubisch, Sibylle Jablonka, Michael Sendtner, Thomas Klopstock, Mamede de Carvalho, Anne Sperfeld, Guntram Borck, Alexander E. Volk, Johannes Dorst, Joachim Weis, Markus Otto, Joachim Schuster, Kelly Del Tredici, Heiko Braak, Karin M. Danzer, Axel Freischmidt, Thomas Meitinger, Tim M. Strom, Albert C. Ludolph, Peter M. Andersen and Jochen H. Weishaupt |
| 264 | 1 | |c 12 January 2018 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.06.2021 | ||
| 520 | |a Heterozygous missense mutations in the N-terminal motor or coiled-coil domains of the kinesin family member 5A (KIF5A) gene cause monogenic spastic paraplegia (HSP10) and Charcot-Marie-Tooth disease type 2 (CMT2). Moreover, heterozygous de novo frame-shift mutations in the C-terminal domain of KIF5A are associated with neonatal intractable myoclonus, a neurodevelopmental syndrome. These findings, together with the observation that many of the disease genes associated with amyotrophic lateral sclerosis disrupt cytoskeletal function and intracellular transport, led us to hypothesize that mutations in KIF5A are also a cause of amyotrophic lateral sclerosis. Using whole exome sequencing followed by rare variant analysis of 426 patients with familial amyotrophic lateral sclerosis and 6137 control subjects, we detected an enrichment of KIF5A splice-site mutations in amyotrophic lateral sclerosis (2/426 compared to 0/6137 in controls; P = 4.2 × 10-3), both located in a hot-spot in the C-terminus of the protein and predicted to affect splicing exon 27. We additionally show co-segregation with amyotrophic lateral sclerosis of two canonical splice-site mutations in two families. Investigation of lymphoblast cell lines from patients with KIF5A splice-site mutations revealed the loss of mutant RNA expression and suggested haploinsufficiency as the most probable underlying molecular mechanism. Furthermore, mRNA sequencing of a rare non-synonymous missense mutation (predicting p.Arg1007Gly) located in the C-terminus of the protein shortly upstream of the splice donor of exon 27 revealed defective KIF5A pre-mRNA splicing in respective patient-derived cell lines owing to abrogation of the donor site. Finally, the non-synonymous single nucleotide variant rs113247976 (minor allele frequency = 1.00% in controls, n = 6137), also located in the C-terminal region [p.(Pro986Leu) in exon 26], was significantly enriched in familial amyotrophic lateral sclerosis patients (minor allele frequency = 3.40%; P = 1.28 × 10-7). Our study demonstrates that mutations located specifically in a C-terminal hotspot of KIF5A can cause a classical amyotrophic lateral sclerosis phenotype, and underline the involvement of intracellular transport processes in amyotrophic lateral sclerosis pathogenesis. | ||
| 650 | 4 | |a Adult | |
| 650 | 4 | |a Aged | |
| 650 | 4 | |a Amyotrophic Lateral Sclerosis | |
| 650 | 4 | |a DNA Mutational Analysis | |
| 650 | 4 | |a Family Health | |
| 650 | 4 | |a Female | |
| 650 | 4 | |a Genetic Association Studies | |
| 650 | 4 | |a Humans | |
| 650 | 4 | |a Kinesin | |
| 650 | 4 | |a Lymphocytes | |
| 650 | 4 | |a Male | |
| 650 | 4 | |a Middle Aged | |
| 650 | 4 | |a Mutation | |
| 650 | 4 | |a RNA, Messenger | |
| 700 | 1 | |a Yılmaz, Rüstem |e VerfasserIn |0 (DE-588)1137641770 |0 (DE-627)177132824X |0 (DE-576)491677960 |4 aut | |
| 700 | 1 | |a Müller, Kathrin |d 1979- |e VerfasserIn |0 (DE-588)140217975 |0 (DE-627)616947437 |0 (DE-576)315098716 |4 aut | |
| 700 | 1 | |a Grehl, Torsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Petri, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meyer, Thomas |d 1967- |e VerfasserIn |0 (DE-588)122622065 |0 (DE-627)705974596 |0 (DE-576)293352143 |4 aut | |
| 700 | 1 | |a Großkreutz, Julian |d 1970- |e VerfasserIn |0 (DE-588)122532589 |0 (DE-627)082000395 |0 (DE-576)293310890 |4 aut | |
| 700 | 1 | |a Weydt, Patrick |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ruf, Wolfgang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Neuwirth, Christoph |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weber, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pinto, Susana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Claeys, Kristl G. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schrank, Berthold |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jordan, Berit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Knehr, Antje |e VerfasserIn |0 (DE-588)127517244X |0 (DE-627)1826735984 |4 aut | |
| 700 | 1 | |a Günther, Kornelia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hübers, Annemarie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zeller, Daniel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kubisch, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jablonka, Sibylle |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Sendtner, Michael |e VerfasserIn |0 (DE-588)1275974112 |0 (DE-627)1915882370 |4 aut | |
| 700 | 1 | |a Klopstock, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a de Carvalho, Mamede |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sperfeld, Anne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Borck, Guntram |e VerfasserIn |4 aut | |
| 700 | 1 | |a Volk, Alexander E. |e VerfasserIn |0 (DE-588)1236728726 |0 (DE-627)1762520486 |4 aut | |
| 700 | 1 | |a Dorst, Johannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weis, Joachim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Otto, Markus |e VerfasserIn |0 (DE-588)1236714962 |0 (DE-627)1762502267 |4 aut | |
| 700 | 1 | |a Schuster, Joachim |e VerfasserIn |4 aut | |
| 700 | 1 | |a Del Tredici, Kelly |e VerfasserIn |4 aut | |
| 700 | 1 | |a Braak, Heiko |e VerfasserIn |4 aut | |
| 700 | 1 | |a Danzer, Karin M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Freischmidt, Axel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meitinger, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Strom, Tim M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ludolph, Albert C. |d 1953- |e VerfasserIn |0 (DE-588)1081317531 |0 (DE-627)845970100 |0 (DE-576)454116195 |4 aut | |
| 700 | 1 | |a Andersen, Peter M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weishaupt, Jochen H. |d 1971- |e VerfasserIn |0 (DE-588)122148924 |0 (DE-627)705789039 |0 (DE-576)293117810 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Brain |d Oxford : Oxford Univ. Press, 1878 |g 141(2018), 3 vom: März, Seite 688-697 |h Online-Ressource |w (DE-627)269242562 |w (DE-600)1474117-9 |w (DE-576)079718728 |x 1460-2156 |7 nnas |a Hot-spot KIF5A mutations cause familial ALS |
| 773 | 1 | 8 | |g volume:141 |g year:2018 |g number:3 |g month:03 |g pages:688-697 |g extent:10 |a Hot-spot KIF5A mutations cause familial ALS |
| 883 | |8 1\p |a cgwrk |d 20250301 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20210616 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 122148924 |a Weishaupt, Jochen H. |m 122148924:Weishaupt, Jochen H. |p 40 |y j | ||
| 998 | |g 127517244X |a Knehr, Antje |m 127517244X:Knehr, Antje |p 16 | ||
| 998 | |g 1137641770 |a Yılmaz, Rüstem |m 1137641770:Yılmaz, Rüstem |p 2 | ||
| 998 | |g 1077188838 |a Brenner, David |m 1077188838:Brenner, David |p 1 |x j | ||
| 999 | |a KXP-PPN1760576204 |e 3938784164 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"title":[{"title_sort":"Brain","title":"Brain","subtitle":"a journal of neurology"}],"pubHistory":["1.1878/79 -"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"note":["Gesehen am 01.12.2020"],"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"text":"141(2018), 3 vom: März, Seite 688-697","extent":"10","pages":"688-697","volume":"141","year":"2018","issue":"3"},"origin":[{"dateIssuedDisp":"1878-","publisher":"Oxford Univ. Press","dateIssuedKey":"1878","publisherPlace":"Oxford"}],"id":{"zdb":["1474117-9"],"issn":["1460-2156"],"eki":["269242562"]},"disp":"Hot-spot KIF5A mutations cause familial ALSBrain","recId":"269242562"}],"note":["Gesehen am 16.06.2021"],"id":{"doi":["10.1093/brain/awx370"],"eki":["1760576204"]},"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"12 January 2018"}],"name":{"displayForm":["David Brenner, Rüstem Yilmaz, Kathrin Müller, Torsten Grehl, Susanne Petri, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Wolfgang Ruf, Christoph Neuwirth, Markus Weber, Susana Pinto, Kristl G. Claeys, Berthold Schrank, Berit Jordan, Antje Knehr, Kornelia Günther, Annemarie Hübers, Daniel Zeller, Christian Kubisch, Sibylle Jablonka, Michael Sendtner, Thomas Klopstock, Mamede de Carvalho, Anne Sperfeld, Guntram Borck, Alexander E. Volk, Johannes Dorst, Joachim Weis, Markus Otto, Joachim Schuster, Kelly Del Tredici, Heiko Braak, Karin M. Danzer, Axel Freischmidt, Thomas Meitinger, Tim M. Strom, Albert C. Ludolph, Peter M. Andersen and Jochen H. Weishaupt"]},"recId":"1760576204","person":[{"role":"aut","given":"David","family":"Brenner","display":"Brenner, David"},{"family":"Yılmaz","given":"Rüstem","role":"aut","display":"Yılmaz, Rüstem"},{"display":"Müller, Kathrin","given":"Kathrin","role":"aut","family":"Müller"},{"family":"Grehl","role":"aut","given":"Torsten","display":"Grehl, Torsten"},{"family":"Petri","role":"aut","given":"Susanne","display":"Petri, Susanne"},{"role":"aut","given":"Thomas","family":"Meyer","display":"Meyer, Thomas"},{"family":"Großkreutz","given":"Julian","role":"aut","display":"Großkreutz, Julian"},{"family":"Weydt","role":"aut","given":"Patrick","display":"Weydt, Patrick"},{"display":"Ruf, Wolfgang","family":"Ruf","role":"aut","given":"Wolfgang"},{"display":"Neuwirth, Christoph","given":"Christoph","role":"aut","family":"Neuwirth"},{"display":"Weber, Markus","family":"Weber","role":"aut","given":"Markus"},{"role":"aut","given":"Susana","family":"Pinto","display":"Pinto, Susana"},{"display":"Claeys, Kristl G.","family":"Claeys","role":"aut","given":"Kristl G."},{"display":"Schrank, Berthold","given":"Berthold","role":"aut","family":"Schrank"},{"display":"Jordan, Berit","family":"Jordan","given":"Berit","role":"aut"},{"family":"Knehr","given":"Antje","role":"aut","display":"Knehr, Antje"},{"display":"Günther, Kornelia","given":"Kornelia","role":"aut","family":"Günther"},{"display":"Hübers, Annemarie","role":"aut","given":"Annemarie","family":"Hübers"},{"family":"Zeller","given":"Daniel","role":"aut","display":"Zeller, Daniel"},{"display":"Kubisch, Christian","role":"aut","given":"Christian","family":"Kubisch"},{"family":"Jablonka","given":"Sibylle","role":"aut","display":"Jablonka, Sibylle"},{"role":"aut","given":"Michael","family":"Sendtner","display":"Sendtner, Michael"},{"display":"Klopstock, Thomas","family":"Klopstock","role":"aut","given":"Thomas"},{"given":"Mamede","role":"aut","family":"de Carvalho","display":"de Carvalho, Mamede"},{"display":"Sperfeld, Anne","family":"Sperfeld","given":"Anne","role":"aut"},{"display":"Borck, Guntram","role":"aut","given":"Guntram","family":"Borck"},{"family":"Volk","role":"aut","given":"Alexander E.","display":"Volk, Alexander E."},{"display":"Dorst, Johannes","family":"Dorst","given":"Johannes","role":"aut"},{"display":"Weis, Joachim","role":"aut","given":"Joachim","family":"Weis"},{"family":"Otto","role":"aut","given":"Markus","display":"Otto, Markus"},{"display":"Schuster, Joachim","given":"Joachim","role":"aut","family":"Schuster"},{"family":"Del Tredici","given":"Kelly","role":"aut","display":"Del Tredici, Kelly"},{"display":"Braak, Heiko","family":"Braak","given":"Heiko","role":"aut"},{"family":"Danzer","given":"Karin M.","role":"aut","display":"Danzer, Karin M."},{"display":"Freischmidt, Axel","role":"aut","given":"Axel","family":"Freischmidt"},{"role":"aut","given":"Thomas","family":"Meitinger","display":"Meitinger, Thomas"},{"display":"Strom, Tim M.","role":"aut","given":"Tim M.","family":"Strom"},{"display":"Ludolph, Albert C.","family":"Ludolph","given":"Albert C.","role":"aut"},{"role":"aut","given":"Peter M.","family":"Andersen","display":"Andersen, Peter M."},{"family":"Weishaupt","given":"Jochen H.","role":"aut","display":"Weishaupt, Jochen H."}],"title":[{"title_sort":"Hot-spot KIF5A mutations cause familial ALS","title":"Hot-spot KIF5A mutations cause familial ALS"}],"physDesc":[{"extent":"10 S."}],"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a BRENNERDAVHOTSPOTKIF1220 | ||